Results 1 to 10 of about 44,461 (250)

Pulsed immune reconstitution therapy in multiple sclerosis [PDF]

Therapeutic Advances in Neurological Disorders, 2019
Whereas drugs used for maintenance/escalation therapy do not maintain their beneficial effect after cessation of therapy, some new highly effective therapies can show prolonged treatment effects after a short treatment course.
Per Soelberg Sorensen, Finn Sellebjerg
doaj   +8 more sources

Opportunities and Obstacles Associated With Sequential Immune Reconstitution Therapy for Multiple Sclerosis: A Case Report [PDF]

Frontiers in Neurology, 2021
Cladribine is an effective disease-modifying treatment for relapsing-remitting multiple sclerosis that acts as an immune reconstitution therapy and is administered in a pulsed manner.
Riccardo Garbo, Daniela Cutuli, Simone Lorenzut, Gian Luigi Gigli, Gian Luigi Gigli, Daniele Bagatto, Mariarosaria Valente, Mariarosaria Valente   +7 more
doaj   +4 more sources

The Meaning of Immune Reconstitution after Alemtuzumab Therapy in Multiple Sclerosis [PDF]

Cells, 2020
Alemtuzumab is a monoclonal antibody that binds to CD52, a protein present on the surface of mature lymphocytes, but not on the stem cells from which these lymphocytes are derived. It is currently used as an immune reconstitution therapy in patients with
Simona Rolla, Alessandro Maglione, Stefania Federica De Mercanti, Marinella Clerico   +3 more
doaj   +5 more sources

Rebooting immunity in congenital athymia: Factors impacting reconstitution with thymus implantationFactors impacting reconstitution with thymus implantation [PDF]

Journal of Human Immunity
Allogeneic processed thymus tissue-agdc (RETHYMIC) is approved therapy for treatment of congenital athymia. Study outcomes include changes in T lymphocyte subsets and T cell function.
Samantha Cresoe-Ortiz, Guglielmo Venturi, Elizabeth A. McCarthy, Benjamin Stewart-Bates, Jennifer R. Heimall, Eveline Y. Wu, John W. Sleasman, Geoffrey Hall   +7 more
doaj   +2 more sources

Immune reconstitution efficacy and associated risk factors for immunological non-response in people living with HIV during long-term antiretroviral therapy: a single-center retrospective cohort study at a tertiary care hospital in China [PDF]

Frontiers in Immunology
Despite sustained virological suppression under antiretroviral therapy (ART), a substantial proportion of people living with HIV (PLWH) fail to achieve adequate immune reconstitution.
Rui Li, Lifeng Liu, Ran Wang, Yuanyi Zhai, Yiming Ren, Wei Hua, Yang Zhang, Lijun Sun, Lili Dai   +8 more
doaj   +2 more sources

Immune Reconstitution Therapy or Continuous Immunosuppression for the Management of Active Relapsing-Remitting Multiple Sclerosis Patients? A Narrative Review. [PDF]

Neurol Ther, 2020
AlSharoqi IA, Aljumah M, Bohlega S, Boz C, Daif A, El-Koussa S, Inshasi J, Kurtuncu M, Müller T, Retief C, Sahraian MA, Shaygannejad V, Slassi I, Taha K, Zakaria M, Sørensen PS.   +15 more
europepmc   +2 more sources

Recent advances in poor HIV immune reconstitution: what will the future look like?

Frontiers in Microbiology, 2023
Combination antiretroviral therapy has demonstrated proved effectiveness in suppressing viral replication and significantly recovering CD4+ T cell count in HIV type-1 (HIV-1)-infected patients, contributing to a dramatic reduction in AIDS morbidity and ...
Wenyuan Zhang, Lianguo Ruan
doaj   +1 more source

Identifying risk factors of immune reconstitution inflammatory syndrome in AIDS patients receiving highly active anti-retroviral therapy

Brazilian Journal of Infectious Diseases, 2013
Immune reconstitution inflammation syndrome typically occurs within days after patients undergo highly active anti-retroviral therapy and is a big hurdle for effective treatment of AIDS patients.
Bo He, Yuhuang Zheng, Meng Liu, Guoqiang Zhou, Xia Chen, Diallo Mamadou, Yan He, Huaying Zhou, Zi Chen   +8 more
doaj   +3 more sources

New‐onset type 1 diabetes and Graves' disease after antiretroviral therapy in a patient with human immunodeficiency virus infection

Journal of Diabetes Investigation, 2023
Patients with human immunodeficiency virus (HIV) infection receiving antiretroviral therapy can develop autoimmune diseases, referred to as immune‐inflammatory reconstitution syndrome.
Maho Taguchi, Noriko Ihana‐Sugiyama, Daisuke Shiojiri, Kazuo Izumi, Michi Kobayashi, Noriko Kodani, Ryotaro Bouchi, Mitsuru Ohsugi, Akiyo Tanabe, Kohjiro Ueki, Hiroshi Kajio   +10 more
doaj   +1 more source

The role of pyroptosis in incomplete immune reconstitution among people living with HIV：Potential therapeutic targets

Pharmacological Research, 2023
Globally, HIV infection causes significant morbidity and mortality, and is a major public health problem. Despite the fact that widespread use of antiretroviral therapy (ART) has substantially altered the natural history of HIV infection from originally ...
Chao Xia, Xue Zhang, Vijay Harypursat, Jing Ouyang, Yaokai Chen   +4 more
doaj   +1 more source