Results 11 to 20 of about 1,062,719 (316)
Exosomes in Immune Regulation [PDF]
Non-Coding RNA, 2021 Exosomes, small extracellular vesicles mediate intercellular communication by transferring their cargo including DNA, RNA, proteins and lipids from cell to cell. Notably, in the immune system, they have protective functions. However in cancer, exosomes acquire new, immunosuppressive properties that cause the dysregulation of immune cells and immune ...
Heidi Schwarzenbach, Peter B. Gahan
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Frontiers in Immunology, 2022 High doses of interleukin-2 (IL-2) have been used for the treatment of melanoma and renal cell carcinoma, but this therapy has limited efficacy, with a ~15% response rate. Remarkably, 7%–9% of patients achieve complete or long-lasting responses.
Tania Carmenate +10 more
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Scientific Reports, 2023 Minimal change disease (MCD), considered one of the major causes of nephrotic syndrome, is a complex pathological condition with disturbances in podocytes’ foot processes.
Kamil Grubczak +6 more
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International Journal of Medical Microbiology, 2021 Numerous studies have associated alterations in the gut microbiota composition with almost every known inflammatory disease. However, proving the biological relevance of distinct microbial signatures and linking specific microorganisms to host phenotypes,
Aida Iljazovic +4 more
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Rheumatology and Therapy, 2023 Introduction Patients with adult-onset Still’s disease (AOSD) are at risk of developing macrophage activation syndrome (MAS), a life-threatening condition. Some cases of MAS have been reported following the use of biological agents, highlighting the need
Soichiro Adachi +7 more
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Scientific Reports, 2021 Pyrin/TRIM20 is expressed in the neutrophils and monocytes/macrophages and regulates caspase-1 activation and interleukin-1β maturation. Although the mutations in the PRY/SPRY domain of pyrin cause familial Mediterranean fever (FMF), the mechanism of how
Sei Samukawa +3 more
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Siglecs and Immune Regulation [PDF]
Annual Review of Immunology, 2012 Sialic acid–binding Ig-like lectins, or Siglecs, vary in their specificity for sialic acid–containing ligands and are mainly expressed by cells of the immune system. Many Siglecs are inhibitory receptors expressed in innate immune cells that regulate inflammation mediated by damage-associated and pathogen-associated molecular patterns (DAMPs and PAMPs).
Shiv, Pillai +3 more
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Hemolysis and immune regulation [PDF]
Current Opinion in Hematology, 2018 Purpose of review Hemolytic anemias caused by premature destruction of red blood cells occur in many disorders including hemoglobinopathies, autoimmune conditions, during infection or following reaction to drugs or transfusions.
Hui, Zhong, Karina, Yazdanbakhsh
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A strong immune response in young adult honeybees masks their increased susceptibility to infection compared to older bees [PDF]
, 2012 Honeybees, Apis mellifera, show age-related division of labor in which young adults perform maintenance ("housekeeping") tasks inside the colony before switching to outside foraging at approximately 23 days old. Disease resistance is an important feature
Baxter, LA +60 more
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HLA class Ib molecules and immune cells in pregnancy and preeclampsia
Frontiers in Immunology, 2014 Despite decades of research, the highly prevalent pregnancy complication preeclampsia, ‘the disease of theories’, has remained an enigma. Indeed, the etiology of preeclampsia is largely unknown.
Snezana eDjurisic +2 more
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