Results 21 to 30 of about 1,062,719 (316)

CD8 T-cell subsets: heterogeneity, functions, and therapeutic potential

Experimental and Molecular Medicine, 2023
CD8 T cells play crucial roles in immune surveillance and defense against infections and cancer. After encountering antigenic stimulation, naïve CD8 T cells differentiate and acquire effector functions, enabling them to eliminate infected or malignant ...
Choong-Hyun Koh, Suyoung Lee, Minkyeong Kwak, Byung-Seok Kim, Yeonseok Chung   +4 more
doaj   +1 more source

Incidence and Distinct Features of Immune Checkpoint Inhibitor-Related Myositis From Idiopathic Inflammatory Myositis: A Single-Center Experience With Systematic Literature Review and Meta-Analysis

Frontiers in Immunology, 2021
Immune checkpoint inhibitor (ICI)-related myositis is a rare, potentially fatal condition that warrants further studies. Its incidence, clinical features, and prognosis remain poorly understood. To address these gaps, we conducted a systematic review and
Naoki Hamada, Ayaka Maeda, Kaoru Takase-Minegishi, Yohei Kirino, Yumiko Sugiyama, Ho Namkoong, Nobuyuki Horita, Ryusuke Yoshimi, Hideaki Nakajima, YCU irAE Working Group, Naoki Hamada, Yohei Kirino, Motohiko Tokuhisa, Keiichi Kondo, Noboru Nakaigawa, Nobuaki Kobayashi, Daisuke Sano, Maki Hagihara, Nobuhiko Oridate, Takeshi Kaneko, Yukie Yamaguchi, Masahiro Yao, Yasushi Ichikawa, Hideaki Nakajima   +23 more
doaj   +1 more source

Rebooting Regulatory T Cell and Dendritic Cell Function in Immune-Mediated Inflammatory Diseases: Biomarker and Therapy Discovery under a Multi-Omics Lens

Biomedicines, 2022
Immune-mediated inflammatory diseases (IMIDs) are a group of autoimmune and chronic inflammatory disorders with constantly increasing prevalence in the modern world.
Dimitra Kerdidani, Nikos E. Papaioannou, Evangelia Nakou, Themis Alissafi   +3 more
doaj   +1 more source

Dietary Regulation of Immunity [PDF]

Immunity, 2020
Integrated immunometabolic responses link dietary intake, energy utilization, and storage to immune regulation of tissue function and is therefore essential for the maintenance and restoration of homeostasis. Adipose-resident leukocytes have non-traditional immunological functions that regulate organismal metabolism by controlling insulin action ...
Lee, Aileen H., Dixit, Vishwa Deep
openaire   +2 more sources

The multiple roles of Rab9 in the endolysosomal system

Communicative & Integrative Biology, 2016
The small GTPase Rab9 has long been described as a protein that mediates endosome-to-trans-Golgi Network (TGN) transport, and specifically mannose-6-phospate receptor (MPR) recycling.
Ana Kucera, Oddmund Bakke, Cinzia Progida   +2 more
doaj   +1 more source

Natural Killer T Cell-Targeted Immunotherapy Mediating Long-term Memory Responses and Strong Antitumor Activity

Frontiers in Immunology, 2017
Current tumor therapies, including immunotherapies, focus on passive eradication or at least reduction of the tumor mass. However, cancer patients quite often suffer from tumor relapse or metastasis after such treatments.
Nyambayar Dashtsoodol, Nyambayar Dashtsoodol, Tomokuni Shigeura, Takuya Tashiro, Minako Aihara, Toshihiro Chikanishi, Hiromi Okada, Keigo Hanada, Hirokazu Sano, Akihiko Kurogi, Masaru Taniguchi   +10 more
doaj   +1 more source

Hinge and Transmembrane Domains of Chimeric Antigen Receptor Regulate Receptor Expression and Signaling Threshold

Cells, 2020
Chimeric antigen receptor (CAR)-T cells have demonstrated significant clinical potential; however, their strong antitumor activity may cause severe adverse effects.
Kento Fujiwara, Ayaka Tsunei, Hotaka Kusabuka, Erika Ogaki, Masashi Tachibana, Naoki Okada   +5 more
doaj   +1 more source

Podocalyxin Expressed in Antigen Presenting Cells Promotes Interaction With T Cells and Alters Centrosome Translocation to the Contact Site

Frontiers in Immunology, 2022
Podocalyxin (PODXL), a cell surface sialomucin expressed in diverse types of normal and malignant cells, mediates cellular adhesion to extracellular matrix and cell-to-cell interaction.
Laura Amo, Javier Díez-García, Estíbaliz Tamayo-Orbegozo, Natalia Maruri, Susana Larrucea   +4 more
doaj   +1 more source

New Insights into the Roles for Basophils in Acute and Chronic Allergy

Allergology International, 2009
Basophils represent less than 1% of peripheral blood leukocytes. They are often recruited to the site of allergic inflammation, albeit in small numbers.
Kaori Mukai, Kazushige Obata, Yusuke Tsujimura, Hajime Karasuyama   +3 more
doaj   +1 more source

CD204-positive monocytes and macrophages ameliorate septic shock by suppressing proinflammatory cytokine production in mice

Biochemistry and Biophysics Reports, 2020
Sepsis is defined as a life-threatening multiorgan dysfunction caused by dysregulated inflammatory response to infection. It remains the primary cause of death from infection if not diagnosed and treated promptly. Therefore, a better understanding of the
Yoshimi Uchida, Gen Nishitai, Kenta Kikuchi, Takumi Shibuya, Kenichi Asano, Masato Tanaka   +5 more
doaj   +1 more source