Results 11 to 20 of about 292,750 (306)

Advances in Innate Immunity to Overcome Immune Rejection during Xenotransplantation. [PDF]

Cells, 2022
Transplantation is an effective approach for treating end-stage organ failure. There has been a long-standing interest in xenotransplantation as a means of increasing the number of available organs. In the past decade, there has been tremendous progress in xenotransplantation accelerated by the development of rapid gene-editing tools and ...
Lu TY, Xu XL, Du XG, Wei JH, Yu JN, Deng SL, Qin C.   +6 more
europepmc   +4 more sources

Modeling rejection immunity [PDF]

Theoretical Biology and Medical Modelling, 2012
Transplantation is often the only way to treat a number of diseases leading to organ failure. To overcome rejection towards the transplanted organ (graft), immunosuppression therapies are used, which have considerable side-effects and expose patients to opportunistic infections.
De Gaetano, Aa, Matone, Aa, Agnes, Ab, Palumbo, Pa, Ria, Fc, Magalini, Sb   +11 more
openaire   +5 more sources

Maternal-foetal immune rejection: parallels between placental CHI and allograft rejection. [PDF]

J Pathol
AbstractChronic histiocytic intervillositis (CHI) is a rare placental inflammatory lesion increasingly viewed through maternal–foetal immune rejection. In this invited commentary, we discuss how a recent study bolsters the paradigm that CHI represents maternal immune rejection of the semi‐allogeneic foetus, analogous to antibody‐mediated rejection in ...
Shangaris P, Martín Monreal MT.
europepmc   +4 more sources

Systematic Review of the Safety of Immune Checkpoint Inhibitors Among Kidney Transplant Patients

Kidney International Reports, 2020
Introduction: Kidney transplant (Ktx) recipients are excluded from clinical trials of immune checkpoint inhibitors. The aim of this systematic review was to assess the safety of immune checkpoint inhibitors among Ktx patients.
Sandhya Manohar, Charat Thongprayoon, Wisit Cheungpasitporn, Svetomir N. Markovic, Sandra M. Herrmann   +4 more
doaj   +1 more source

CARARIME: Interactive web server for comprehensive analysis of renal allograft rejection in immune microenvironment

Frontiers in Immunology, 2022
BackgroundRenal transplantation is a very effective treatment for renal failure patients following kidney transplant. However, the clinical benefit is restricted by the high incidence of organ rejection.
Xiaoyou Liu, Ding Liu, Song Zhou, Weihao Jiang, Jie Zhang, Jianmin Hu, Guorong Liao, Jun Liao, Zefeng Guo, Yuzhu Li, Siqiang Yang, Shichao Li, Hua Chen, Ying Guo, Min Li, Lipei Fan, Liuyang Li, Ming Zhao, Yongguang Liu   +18 more
doaj   +1 more source

An Efficacious Transgenic Strategy for Triple Knockout of Xeno-Reactive Antigen Genes GGTA1, CMAH, and B4GALNT2 from Jeju Native Pigs

Vaccines, 2022
Pigs are promising donors of biological materials for xenotransplantation; however, cell surface carbohydrate antigens, including galactose-alpha-1,3-galactose (α-Gal), N-glycolylneuraminic acid (Neu5Gc), and Sd blood group antigens, play a significant ...
Seungwon Yoon, Seulgi Lee, Chungyu Park, Hyunyong Choi, Minwoo Yoo, Sang Chul Lee, Cheol-Ho Hyun, Nameun Kim, Taeyoung Kang, Eugene Son, Mrinmoy Ghosh, Young-Ok Son, Chang-Gi Hur   +12 more
doaj   +1 more source

Co-expression of HLA-E and HLA-G on genetically modified porcine endothelial cells attenuates human NK cell-mediated degranulation

Frontiers in Immunology, 2023
Natural killer (NK) cells play an important role in immune rejection in solid organ transplantation. To mitigate human NK cell activation in xenotransplantation, introducing inhibitory ligands on xenografts via genetic engineering of pigs may protect the
Arthur A. Cross-Najafi, Kristine Farag, Abdulkadir Isidan, Wei Li, Wenjun Zhang, Zhansong Lin, Julia R. Walsh, Kevin Lopez, Yujin Park, Nancy G. Higgins, David K.C. Cooper, Burcin Ekser, Ping Li   +12 more
doaj   +1 more source

Siah2 control of T-regulatory cells limits anti-tumor immunity. [PDF]

, 2020
Understanding the mechanisms underlying anti-tumor immunity is pivotal for improving immune-based cancer therapies. Here, we report that growth of BRAF-mutant melanoma cells is inhibited, up to complete rejection, in Siah2-/- mice.
Aifantis, Ioannis, Bosenberg, Marcus, Bradley, Linda M, Brown, Kevin, Dolgalev, Igor, Feng, Yongmei, Hockemeyer, Kathryn, Li, Yan, Marine, Jean-Christophe, Otero, Dennis C, Poźniak, Joanna, Rambow, Florian, Ronai, Ze'ev A, Scortegagna, Marzia, Tinoco, Roberto, Zhang, Tongwu   +15 more
core   +2 more sources

Gene Expression Profiling of Bronchoalveolar Lavage Cells Preceding a Clinical Diagnosis of Chronic Lung Allograft Dysfunction. [PDF]

, 2017
BackgroundChronic Lung Allograft Dysfunction (CLAD) is the main limitation to long-term survival after lung transplantation. Although CLAD is usually not responsive to treatment, earlier identification may improve treatment prospects.MethodsIn a nested ...
Ardehali, Abbas, Belperio, John A, Birjandi, Shirin, DerHovanessian, Ariss, Elashoff, David, Gregson, Aric L, Lynch, Joseph P, Palchevskiy, Vyacheslav, Palmer, Scott M, Patel, Naman, Ross, David J, Saggar, Rajan, Sayah, David M, Shino, Michael Y, Wang, Xiaoyan, Weigt, S Samuel   +15 more
core   +8 more sources

Characterizing pre-transplant and post-transplant kidney rejection risk by B cell immune repertoire sequencing. [PDF]

, 2019
Studying immune repertoire in the context of organ transplant provides important information on how adaptive immunity may contribute and modulate graft rejection. Here we characterize the peripheral blood immune repertoire of individuals before and after
Liberto, Juliane M, Pineda, Silvia, Sarwal, Minnie M, Sigdel, Tara K, Sirota, Marina, Vincenti, Flavio   +5 more
core   +3 more sources