Results 21 to 30 of about 292,750 (306)
Immune Checkpoints Expression in Chronic Lung Allograft Rejection [PDF]
Frontiers in Immunology, 2021 Chronic lung allograft dysfunction (CLAD) is the main cause of poor survival and low quality of life of lung transplanted patients. Several studies have addressed the role of dendritic cells, macrophages, T cells, donor specific as well as anti-HLA antibodies, and interleukins in CLAD, but the expression and function of immune checkpoint molecules has ...
Ilaria Righi +16 more
openaire +3 more sources
The PPARγ Agonist Rosiglitazone Suppresses Syngeneic Mouse SCC (Squamous Cell Carcinoma) Tumor Growth through an Immune-Mediated Mechanism [PDF]
, 2019 Recent evidence suggests that PPARγ agonists may promote anti-tumor immunity. We show that immunogenic PDV cutaneous squamous cell carcinoma (CSCC) tumors are rejected when injected intradermally at a low cell number (1 × 106) into immune competent ...
Derr-Yellin, Ethel +4 more
core +1 more source
Corneal Allograft Rejection: Immunopathogenesis to Therapeutics [PDF]
, 2014 Corneal transplantation is among the most successful solid organ transplants. However, despite low rejection rates of grafts in the ‘low-risk’ setting, rejection can be as high as 70% when grafted into ‘high-risk’ recipient beds. Under normal homeostatic
Hamrah, Pedram, Qazi, Yureeda
core +1 more source
Indian Journal of Transplantation, 2021 Introduction: The aim of the study was to assess the peripheral blood lymphocyte subsets as immune markers for acute cellular rejection (ACR) in the living donor liver-transplant (LDLT) recipients using high-dimensional flow cytometry.
Pradeep Kumar +4 more
doaj +1 more source
Innate immunity and cardiac allograft rejection [PDF]
Kidney International, 2010 The development of immunosuppressive drugs to control adaptive immune responses has led to the success of heart transplantation as a therapy for end-stage heart failure. However, these agents are largely ineffective in suppressing components of the innate immune system.
Timothy M, Millington, Joren C, Madsen
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Cellular Immune Responses in Islet Xenograft Rejection
Frontiers in Immunology, 2022 Porcine islets surviving the acute injury caused by humoral rejection and IBMIR will be subjected to cellular xenograft rejection, which is predominately mediated by CD4+T cells and is characterised by significant infiltration of macrophages, B cells and T cells (CD4+and CD8+).
Min Hu +7 more
openaire +3 more sources
Multiple gene modifications of pigs for overcoming obstacles of xenotransplantation
National Science Open, 2023 Xenotransplantation, involving animal organ transplantation into humans to address the human organ shortage, has been studied since the 17th century.
Wu Han, Lian Meng, Lai Liangxue
doaj +1 more source
Chimerism after organ transplantation [PDF]
, 1997 Recent evidence suggests that passenger leukocytes migrate after organ transplantation and produce persistent chimerism, which is essential for sustained survival of the allograft.
Demetris, AJ +6 more
core +1 more source
IgE-Mediated Immune Response and Antibody-Mediated Rejection [PDF]
Clinical Journal of the American Society of Nephrology, 2020 Background and objectives Active antibody-mediated rejection is the main cause of kidney transplant loss, sharing with SLE the alloimmune response and the systemic activation of the IFN-α pathway. IgE-mediated immune response plays a key role in the development of SLE nephritis and is associated with IFN-α secretion. The aim of
Rascio F. +12 more
openaire +6 more sources
Frontiers in Immunology, 2022 Immune rejection is the major limitation for porcine xenograft survival in primate recipients. Proinflammatory cytokines play important roles in immune rejection and have been found to mediate the pathological effects in various clinical and experimental
Weilong Li +14 more
doaj +1 more source