Results 31 to 40 of about 292,750 (306)
Potential benefits and risks of clinical xenotransplantation [PDF]
, 2012 The transplantation of organs and cells from pigs into humans could overcome the critical and continuing problem of the lack of availability of deceased human organs and cells for clinical transplantation.
Ayares, D, Cooper, DKC
core +2 more sources
Drug Delivery, 2019 Tacrolimus has been widely applied to prevent organ rejection after transplantation. However, the conventional pharmaceutical formulation of tacrolimus limits its applications in ocular therapy due to its hydrophobicity and low corneal penetrability.
Qianni Wu +9 more
doaj +1 more source
Biomarkers in solid organ transplantation: establishing personalized transplantation medicine. [PDF]
, 2011 Technological advances in molecular and in silico research have enabled significant progress towards personalized transplantation medicine. It is now possible to conduct comprehensive biomarker development studies of transplant organ pathologies ...
Khatri, Purvesh +3 more
core +3 more sources
Cells, 2023 Natural killer (NK) cells play a vital role in xenotransplantation rejection. One approach to induce NK cell immune tolerance is to prevent the NK cell-mediated direct killing of porcine cells by targeting the interaction of the activating receptor NKG2D
Kevin J. Lopez +9 more
doaj +1 more source
Preventing Allograft Rejection by Targeting Immune Metabolism [PDF]
Cell Reports, 2015 Upon antigen recognition and co-stimulation, T lymphocytes upregulate the metabolic machinery necessary to proliferate and sustain effector function. This metabolic reprogramming in T cells regulates T cell activation and differentiation but is not just a consequence of antigen recognition.
Chen-Fang Lee +11 more
openaire +3 more sources
Frontiers in Medicine, 2023 IntroductionResveratrol is an immune modulator that can reduce M1 macrophage polarization in vitro. Reducing macrophage recruitment and M1 polarization can prevent corneal allograft rejection (CGR).
Chenjia Xu +7 more
doaj +1 more source
Not All Antibodies Are Created Equal: Factors That Influence Antibody Mediated Rejection. [PDF]
, 2017 Consistent with Dr. Paul Terasaki's "humoral theory of rejection" numerous studies have shown that HLA antibodies can cause acute and chronic antibody mediated rejection (AMR) and decreased graft survival. New evidence also supports a role for antibodies
Butler, Carrie L +3 more
core +4 more sources
Трансплантология (Москва), 2023 Aim. The aim of this review was to analyze publications describing studies focusing on the pathophysiological mechanisms of calcification of bioprosthetic heart valves, and to substantiate new and promising methods of calcification prevention for the ...
A. E. Kostyunin +3 more
doaj +1 more source
On the crossroad between tolerance and posttransplant lymphoma. [PDF]
, 1997 The role of the Epstein-Barr virus in the development of post-transplant lymphomas is well established. However, not all lymphomas that arise in these patients contain Epstein-Barr virus, suggesting that other cofactors are involved in tumor pathogenesis.
Nalesnik, Michael A, Starzl, Thomas E
core +1 more source
Transplant Immunology in Liver Transplant, Rejection, and Tolerance
LiversLiver transplantation is the most effective treatment for end-stage liver disease. Despite improvements in surgical techniques, transplant rejection remains a significant concern.
Masaya Yokoyama +12 more
doaj +1 more source