Results 51 to 60 of about 1,393,861 (205)

Individualized immunosuppression in transplant patients: potential role of pharmacogenetics. [PDF]

, 2012
The immunosuppressive drugs used to prevent the rejection of transplanted organs have a narrow therapeutic index. Under treatment results in episodes of rejection leading to either damage or loss of the organ. Over immunosuppression increases the risk of
MacPhee IA, Abboudi H, Macphee, IA, Abboudi, H   +3 more
core   +1 more source

Mechanistic insights into neutrophil involvement in liver transplant ischemia-reperfusion injury and rejection

Frontiers in Immunology
Ischemia-reperfusion injury (IRI) and subsequent rejection remain the paramount pathological barriers to long-term graft survival following liver transplantation.
Zhipeng She, Hailun Cai, Xinqiang Li, Jinhui Chen, Ying Chen, Jinzhen Cai, Bin Wu   +6 more
doaj   +1 more source

Multiple gene modifications of pigs for overcoming obstacles of xenotransplantation

National Science Open, 2023
Xenotransplantation, involving animal organ transplantation into humans to address the human organ shortage, has been studied since the 17th century.
Wu Han, Lian Meng, Lai Liangxue
doaj   +1 more source

The Innate Immune System in Allograft Rejection and Tolerance [PDF]

The Journal of Immunology, 2007
Abstract As T cells alone are both necessary and sufficient for the rejection of virtually all allogeneic tissues, much of transplantation immunology has focused on cells of the adaptive immune system. During the past decade, advances in our understanding of innate responses to pathogen-associated molecules have spurred a “rediscovery ...
David F, LaRosa, Adeeb H, Rahman, Laurence A, Turka   +2 more
openaire   +2 more sources

Rejection sampling in demand systems [PDF]

, 1992
We illustrate the method of rejection sampling in a Bayesian application of a new approach toı estimating Demand Systems. This approach, suggested by Varian (1990), is based on a generalization of Afriat's (1967) efficiency index.
Ley, Eduardo, Steel, Mark F.J.
core   +1 more source

Rejection and acceptance across contexts: parents and peers as risks and buffers for early adolescent psychopathology. the TRAILS Study [PDF]

, 2009
In a large sample of early adolescents (T2: n = 1023; M age = 13.51; 55.5% girls) it was investigated whether the effects of parental and peer acceptance and rejection on psychopathology (externalizing and internalizing problems) remain when taking into ...
Ormel, J., Omvlee, A., Veenstra, René, Ormel, Johan, Johan Ormel, René Veenstra, Sentse, Miranda, Veenstra, René,, Veenstra, R., Ormel, Johan,, Lindenberg, S., Annelies Omvlee, Lindenberg, Siegwart, Sentse, Miranda,, Siegwart Lindenberg, Lindenberg, Siegwart; id_orcid, Miranda Sentse, Omvlee, Annelies, Sentse, M., Lindenberg, Siegwart,, Omvlee, Annelies,, Veenstra, René; id_orcid   +21 more
core   +2 more sources

Immune modulation for β-cell replacement in type 1 diabetes

Frontiers in Immunology
Type 1 diabetes (T1D) is driven by autoimmune destruction of pancreatic β-cells and remains incurable despite major advances in insulin delivery and glucose-monitoring technologies.
Qin Yang, Yuanhui Song, James F. Markmann, Ji Lei, Ji Lei   +4 more
doaj   +1 more source

Human IL-17 and TNF-α Additively or Synergistically Regulate the Expression of Proinflammatory Genes, Coagulation-Related Genes, and Tight Junction Genes in Porcine Aortic Endothelial Cells

Frontiers in Immunology, 2022
Immune rejection is the major limitation for porcine xenograft survival in primate recipients. Proinflammatory cytokines play important roles in immune rejection and have been found to mediate the pathological effects in various clinical and experimental
Weilong Li, Pengfei Chen, Yanli Zhao, Mengtao Cao, Wenjun Hu, Litao Pan, Huimin Sun, Dongsheng Huang, Hanxi Wu, Zhuoheng Song, Huanli Zhong, Lisha Mou, Shaodong Luan, Xiehui Chen, Hanchao Gao   +14 more
doaj   +1 more source

Transplantation immunology: aspects of allo- and EBV-specific reactivity : the EBV non-infected elderly - factors of resistance [PDF]

, 2010
Defining the relevant components of cellular alloimmunity remains an important unresolved issue in clinical transplantation. The most promising marker of cellular alloreactivity available to date is donor-specific secretion of interferon-gamma (IFN-) as ...
Durovic, Bojana
core   +1 more source

Recipient Immune Repertoire and Engraftment Site Influence the Immune Pathway Effecting Acute Hepatocellular Allograft Rejection

Cell Transplantation, 2008
As novel acute allograft rejection mechanisms are being discovered, determining the conditions that promote or subvert these distinct rejection pathways is important to interpret the clinical relevance of these pathways for specific recipient groups as ...
Phillip H. Horne, Keri E. Lunsford, Jon P. Walker, Mitchel A. Koester, Ginny L. Bumgardner   +4 more
doaj   +1 more source