Results 11 to 20 of about 12,660,283 (403)

Potential Role of the Galectin-9/TIM-3 Axis in the Disparate Progression of SARS-CoV-2 in a Married Couple: A Case Report

Biomedicine Hub, 2021
We report the disparate clinical progression of a couple infected by SARS-CoV-2 based on their immune checkpoint (IC) levels and immune cell distribution in blood from admission to exitus in patient 1 and from admission to discharge and recovery in ...
Alejandro Martín-Quirós, Charbel Maroun-Eid, José Avendaño-Ortiz, Roberto Lozano-Rodríguez, Jaime Valentín Quiroga, Verónica Terrón, Karla Montalbán-Hernández, Miguel A. García-Garrido, Elena Muñoz del Val, Álvaro del Balzo-Castillo, Carolina Rubio, Carolina Cubillos-Zapata, Luis A. Aguirre, Eduardo López-Collazo   +13 more
doaj   +1 more source

Single-cell multi-omics analysis of the immune response in COVID-19

Nature Medicine, 2021
Analysis of human blood immune cells provides insights into the coordinated response to viral infections such as severe acute respiratory syndrome coronavirus 2, which causes coronavirus disease 2019 (COVID-19).
Emily Stephenson, G. Reynolds, R. Botting, F. Calero-Nieto, Michael D. Morgan, Z. Tuong, K. Bach, W. Sungnak, Kaylee B. Worlock, Masahiro Yoshida, Natsuhiko Kumasaka, K. Kania, J. Engelbert, B. Olabi, J. Spegarova, Nicola K. Wilson, N. Mende, Laura Jardine, Louis C. S. Gardner, Issac Goh, D. Horsfall, J. McGrath, S. Webb, M. Mather, Rik G. H. Lindeboom, Emma Dann, N. Huang, K. Polański, E. Prigmore, Florian Gothe, J. Scott, R. Payne, K. Baker, Aidan T. Hanrath, Ina Schim van der Loeff, A. Barr, A. Sánchez-González, L. Bergamaschi, Federica Mescia, Josephine L. Barnes, E. Kilich, Angus de Wilton, A. Saigal, Aarash Saleh, S. Janes, C. Smith, N. Gopee, Caroline L. Wilson, P. Coupland, J. Coxhead, V. Kiselev, Stijn van Dongen, J. Bacardit, Hamish W. King, Stephen John R. Gordon Ian G. Ravindra K. Christoph Nathal Baker Bradley Dougan Goodfellow Gupta Hess Kingsto, S. Baker, J. Bradley, G. Dougan, I. Goodfellow, Ravindra K. Gupta, C. Hess, N. Kingston, P. Lehner, N. Matheson, Willem H. Owehand, C. Saunders, Kenneth G. C. Smith, C. Summers, James E. D. Thaventhiran, M. Toshner, M. Weekes, Ashlea Bucke, J. Calder, L. Canna, Jason Domingo, A. Elmer, S. Fuller, Julie Harris, S. Hewitt, J. Kennet, Sherly Jose, Jenny Kourampa, A. Meadows, Criona O’Brien, Jane Price, Cherry Publico, Rebecca J Rastall, C. Ribeiro, J. Rowlands, Valentina Ruffolo, Hugo Tordesillas, Ben Bullman, B. Dunmore, Stuart Fawke, S. Gräf, Josh Hodgson, Christopher Huang, K. Hunter, E. Jones, E. Legchenko, C. Matara, Jennifer M Martin, Ciara O’Donnell, L. Pointon, Nicole Pond, J. Shih, R. Sutcliffe, T. Tilly, C. Treacy, Z. Tong, Jennifer Wood, Marta Wylot, Ariana Betancourt, G. Bower, Aloka De Sa, M. Epping, O. Huhn, Sarah Jackson, Isobel Jarvis, J. Marsden, Francesca L. Nice, G. Okecha, Ommar Omarjee, Marianne R Perera, N. Richoz, Rahul Sharma, L. Turner, E. De Bie, K. Bunclark, Maša Josipović, Michael Mackay, A. Michael, Sabrina Rossi, Mayurun Selvan, Sarah Spencer, Cissy Yong, A. Ansaripour, L. Mwaura, C. Patterson, Gary Polwarth, P. Polgarova, G. D. Stefano, J. Allison, H. Butcher, D. Caputo, Debbie Clapham-Riley, Eleanor F. Dewhurst, A. Furlong, B. Graves, J. Gray, Tasmin Ivers, Mary A. Kasanicki, Emma Le Gresley, R. Linger, Sara E. Meloy, Frances E. Muldoon, Nigel R. Ovington, S. Papadia, Isabel Phelan, H. Stark, K. Stirrups, Paul Townsend, Neil E. Walker, J. Webster, A. Rostron, A. Simpson, S. Hambleton, E. Laurenti, P. Lyons, K. Meyer, M. Nikolić, C. Duncan, Kenneth G. C. Smith, S. Teichmann, M. Clatworthy, J. Marioni, B. Göttgens, M. Haniffa   +177 more
semanticscholar   +1 more source

Redox regulation of the immune response

Cellular & Molecular Immunology, 2022
The immune-inflammatory response is associated with increased nitro-oxidative stress. The aim of this mechanistic review is to examine: (a) the role of redox-sensitive transcription factors and enzymes, ROS/RNS production, and the activity of cellular ...
G. Morris, Maria Gevezova, V. Sarafian, Michael Maes   +3 more
semanticscholar   +1 more source

CD83 expression characterizes precursor exhausted T cell population

Communications Biology, 2023
CD83, a member of the immunoglobulin superfamily, is a novel marker to discriminate precursor exhausted T cells from terminally exhausted and bystander tumor-infiltrating T-lymphocytes.
Zhiwen Wu, Toshiaki Yoshikawa, Satoshi Inoue, Yusuke Ito, Hitomi Kasuya, Takahiro Nakashima, Haosong Zhang, Saki Kotaka, Waki Hosoda, Shiro Suzuki, Yuki Kagoya   +10 more
doaj   +1 more source

Identification of sSIGLEC5 and sLAG3 as New Relapse Predictors in Lung Cancer

Biomedicines, 2022
Lung cancer (LC) continues to be the leading cause of cancer-related deaths in both men and women worldwide. After complete tumour resection, around half of the patients suffer from disease relapse, emphasising the critical need for robust relapse ...
Karla Montalbán-Hernández, José Carlos Casalvilla-Dueñas, Patricia Cruz-Castellanos, Laura Gutierrez-Sainz, Roberto Lozano-Rodríguez, José Avendaño-Ortiz, Carlos del Fresno, Javier de Castro-Carpeño, Eduardo López-Collazo   +8 more
doaj   +1 more source

The cancer metabolic reprogramming and immune response

Molecular Cancer, 2021
The overlapping metabolic reprogramming of cancer and immune cells is a putative determinant of the antitumor immune response in cancer. Increased evidence suggests that cancer metabolism not only plays a crucial role in cancer signaling for sustaining ...
Longzheng Xia, Linda Oyang, Jinguan Lin, Shiming Tan, Yaqian Han, Nayiyuan Wu, Pin Yi, Lu Tang, Qing Pan, Shan Rao, Jiaxin Liang, Yanyan Tang, Min Su, Xia Luo, Yiqing Yang, Ying-rui Shi, Hui Wang, Yujuan Zhou, Q. Liao   +18 more
semanticscholar   +1 more source

Gut microbiota impact on the peripheral immune response in non-alcoholic fatty liver disease related hepatocellular carcinoma

Nature Communications, 2021
The gut microbiota is reported to modulate the immune response in hepatocellular carcinoma (HCC). Here, we employ metagenomic and metabolomic studies to characterise gut microbiota in patients with non-alcoholic fatty liver disease (NAFLD) related ...
J. Behary, N. Amorim, Xiao-Tao Jiang, A. Raposo, L. Gong, E. McGovern, Ragy Ibrahim, F. Chu, C. Stephens, H. Jebeili, V. Fragomeli, Y. Koay, M. Jackson, J. O’Sullivan, M. Weltman, G. McCaughan, E. El-Omar, A. Zekry   +17 more
semanticscholar   +1 more source

Aging, Immunity, and COVID-19: How Age Influences the Host Immune Response to Coronavirus Infections?

Frontiers in Physiology, 2021
The novel coronavirus severe acute respiratory syndrome coronavirus 2 causing the Coronavirus disease (COVID-19) pandemic has ravaged the world with over 72 million total cases and over 1.6 million deaths worldwide as of early December 2020.
Varnica Bajaj, N. Gadi, Allison P. Spihlman, Samantha C. Wu, C. Choi, Vaishali R. Moulton   +5 more
semanticscholar   +1 more source

Dysregulation of immune response in patients with COVID-19 in Wuhan, China

Clinical Infectious Diseases, 2020
Background In December 2019, coronavirus disease 2019 (COVID-19) emerged in Wuhan and rapidly spread throughout China. Methods Demographic and clinical data of all confirmed cases with COVID-19 on admission at Tongji Hospital from January 10 to February ...
C. Qin, Luo-Qi Zhou, Zi-Wei Hu, Shuoqi Zhang, Sheng Yang, Yu Tao, Cuihong Xie, K. Ma, Ke Shang, Wei Wang, Daishi Tian   +10 more
semanticscholar   +1 more source

NAD+ metabolism, stemness, the immune response, and cancer

Signal Transduction and Targeted Therapy, 2021
NAD + was discovered during yeast fermentation, and since its discovery, its important roles in redox metabolism, aging, and longevity, the immune system and DNA repair have been highlighted.
L. Navas, A. Carnero
semanticscholar   +1 more source