Results 21 to 30 of about 2,786,821 (240)

Autophagy and the Immune Response [PDF]

, 2019
Innate immunity and adaptive immunity play critical roles in maintaining normal physiological functions and the development of diseases. In innate immune responses, heterogeneous autophagy can directly remove intracellular pathogens while activating PRRs, including TLRs and NLRs, to trigger their signal transduction pathways and promote NKT cell ...
Zhuo-Wei Hu, Heng Lin, Bing Cui, Jin-mei Yu, Jiao-jiao Yu   +4 more
openaire   +3 more sources

Neurodegeneration: Potential Causes, Prevention, and Future Treatment Options [PDF]

, 2011
Here I advance a hypothesis that neurodegeneration is a natural process associated with aging due to the loss of genetic redundancy following a mathematical model R(t) = R0(1-αe(βC+γI+δEt)t), where the calorie intake (C) and ...
Zhongtao Zhang
core   +2 more sources

Correlations in the T Cell Response to Altered Peptide Ligands

, 2004
The vertebrate immune system is a wonder of modern evolution. Occasionally, however, correlations within the immune system lead to inappropriate recruitment of preexisting T cells against novel viral diseases.
Arstila, Bachmann, Bachmann, Blattman, Bogarad, Chandler, Deem, Derrida, Derrida, Drossel, Garboczi, Garcia, Jeong-Man Park, Kauffman, Kedl, Kesmir, Klenerman, Lee, Lee, Martin, Michael W. Deem, Perelson, Perelson, Schodin, Singh, Sloan-Lancaster, Sourdive   +26 more
core   +1 more source

Functional diversity of chemokines and chemokine receptors in response to viral infection of the central nervous system. [PDF]

, 2006
Encounters with neurotropic viruses result in varied outcomes ranging from encephalitis, paralytic poliomyelitis or other serious consequences to relatively benign infection.
A. Meyer, A.A. Dandekar, A.D. Luster, B. Mehrad, B. Parra, B. Parra, B.D. Pearce, B.P. Chen, B.T. Fife, C. Gerard, C. Ramakrishna, C. Ramakrishna, C.A. Biron, C.E. Patterson, C.J. Raport, C.M. Hogaboam, D. Franciotta, D. Galimberti, D. Whiting, D.D. Taub, D.J. Mahad, D.M. Muller, D.N. Cook, D.P. Widney, E. Lazzeri, E.J. McMahon, F.R. Fischer, F.S. Cheever, G. Penna, G. Penna, G.B. Huffnagle, G.C. Hildebrandt, G.F. Wu, H. Bartosik-Psujek, H.G. Fischer, H.G. Fischer, I. Banisor, I. Clark-Lewis, I. Salomon, I. Tsunoda, I.E. Flesch, J. Gosling, J.B. Domachowske, J.C. Houck, J.F. Bazan, J.H. Dufour, J.H. Xie, J.J. Phillips, J.M. Farber, J.S. Haring, J.S. Haring, J.S. Williamson, J.S. Williamson, K. Holmes, K. McIntosh, K.E. Balashov, K.S. Held, K.S. Warmington, K.V. Holmes, L. Boring, L. Boring, L. Cartier, L. Gu, L. Gu, L. Pewe, L. Pewe, M. Baggiolini, M. Greter, M. Matsui, M.A. Olszewski, M.J. Buchmeier, M.J. Trifilo, M.J. Trifilo, M.J. Trifilo, M.M. Lai, M.T. Lin, M.T. Lin, M.T. Liu, M.T. Liu, M.T. Liu, N. Sato, N.J. Megjugorac, N.W. Marten, R. Gade-Andavolu, R. Watanabe, R.F. Castro, R.S. Klein, S. Narumi, S. Qin, S. Xue, S.A. Stohlman, S.A. Stohlman, S.D. Miller, S.M. Stamatovic, S.R. Perlman, T.E. Lane, T.E. Lane, T.E. Lane, T.L. Sorensen, T.L. Sorensen, T.S. Kim, T.S. Kim, W.G. Glass, W.G. Glass, W.G. Glass, W.G. Glass, W.J. Karpus, Y. Zhang, Y. Zhou   +108 more
core   +1 more source

Host immune response to cytomegalovirus [PDF]

, 1987
To confirm that immediate-early (IE) genes of murine cytomegalovirus (MCMV) give rise to antigens recognized by specific cytolytic T lymphocytes (CTL), a 10.8-kilobase fragment of MCMV DNA which is abundantly transcribed at IE times was transfected into ...
Keil, Günther M., Koszinowski, Ulrich H., Reddehase, Matthias J., Schickedanz, Jörg   +3 more
core  

The dual nature of TDC – bridging dendritic and T cells in immunity

FEBS Letters, EarlyView.
TDC are hematopoietic cells combining dendritic and T cell features. They reach secondary lymphoid organs (SLOs) and peripheral organs (liver and lungs) after FLT3‐dependent development in the bone marrow and maturation in the thymus. TDC are activated and enriched in SLOs upon viral infection, suggesting that they might play unique immune roles, since
Maria Nelli, Mirela Kuka
wiley   +1 more source

Modelling cross-reactivity and memory in the cellular adaptive immune response to influenza infection in the host

, 2016
The cellular adaptive immune response plays a key role in resolving influenza infection. Experiments where individuals are successively infected with different strains within a short timeframe provide insight into the underlying viral dynamics and the ...
Ada W.C. Yan, Antia, Badovinac, Barber, Beauchemin, Blattman, Bocharov, Bodewes, Boianelli, Boon, Bortnick, Braciale, Brown, Brown, Bui, Cao, Carolan, Carpenter, Chao, Christensen, Crowe, Davenport, De Boer, Dobrovolny, Epstein, Faroudi, Grayson, Grebe, Greenbaum, Hancioglu, Handel, Hou, Iwasaki, James M. McCaw, Jameson, Jane M. Heffernan, Jodie McVernon, Kaech, Kaech, Karen L. Laurie, Kees, Komadina, Kreijtz, Kris, Kylie M. Quinn, Laurie, Laurie, Lee, Lehmann-Grube, Luciani, Luckheeram, Marchuk, Martin, McElhaney, McMichael, Mehlhop-Williams, Miao, Miao, Murali-Krishna, Nicole L. La Gruta, Nowak, Pawelek, Pengxing Cao, Petrie, Quinn, Rammensee, Selin, Shin, Smith, Smith, Smith, Sridhar, Steel, Sze, Tanchot, Terajima, Tscharke, van Stipdonk, Veiga-Fernandes, Veiga-Fernandes, Wells, Wherry, Wirth, Wodarz, Wodarz, Yan, Yap, Yewdell, Yewdell, Zarnitsyna, Zehn   +90 more
core   +1 more source

Innate immunity, assessed by plasma NO measurements, is not suppressed during the incubation fast in eiders [PDF]

, 2006
Immunity is hypothesized to share limited resources with other physiological functions and may mediate life history trade-offs, for example between reproduction and survival.
Adamo, Archer, Berczi, Bourgeon, Bourgeon, Crippen, Criscuolo, Criscuolo, Daniel Ricquier, Demas, Demas, Demas, Elizalde, Eraud, Faggioni, François Criscuolo, Gross, Gullo, Guzik, Hamilton, Hangalapura, Hangalapura, Hanssen, Hanssen, Hanssen, Hanssen, Harvey, Hickman-Miller, Jarosinski, Keil, Korschgen, Lillehoj, Lord, Lourenco, Love, Lõhmus, Lõhmus, MacColl, MacDonald, Martin, Nilsson, Nordling, Norris, Ricart-Jané, Ricklefs, Rodriguez, Roitt, Råberg, Salman, Sheldon, Sophie Bourgeon, Svensson, Szabo, Thierry Raclot, Tieleman, Tosi, Verhulst, Viney, von Schantz, Wiersma, Yoccoz, Yvon Le Maho, Zuk   +62 more
core   +3 more sources

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

Multiscale model for the effects of adaptive immunity suppression on the viral therapy of cancer

, 2013
Oncolytic virotherapy - the use of viruses that specifically kill tumor cells - is an innovative and highly promising route for treating cancer. However, its therapeutic outcomes are mainly impaired by the host immune response to the viral infection.
Ferreira, Silvio C, Martins, Marcelo L, Paiva, Leticia R, Silva, Hallan S   +3 more
core   +2 more sources