Results 21 to 30 of about 1,889,554 (264)

Changes in Iron Metabolism Induced by Anti-Interleukin-6 Receptor Monoclonal Antibody are Associated with an Increased Risk of Infection

Pharmaceuticals, 2019
(1) Background: Treatment of patients with rheumatoid arthritis (RA) with an anti-IL-6 receptor (anti-IL-6R) monoclonal antibody (tocilizumab) has been found to influence iron metabolism.
Renata Ribeiro, Frederico Batista, Filipe Seguro Paula, José Delgado Alves   +3 more
doaj   +1 more source

Intranasal Immunization Promotes Th17 Immune Responses [PDF]

The Journal of Immunology, 2009
Abstract Th17 cells are a lineage of CD4+ T cells characterized by IL-17 secretion, which plays a crucial role in immune responses against important respiratory pathogens, such as Mycobacterium tuberculosis. In this study, we demonstrated that intranasal (i.n.) immunization leads per se to Th17-biased immune responses, regardless of ...
Beata M, Zygmunt, Faiza, Rharbaoui, Lothar, Groebe, Carlos A, Guzman   +3 more
openaire   +2 more sources

In-vivo expressed Mycobacterium tuberculosis antigens recognised in three mouse strains after infection and BCG vaccination

npj Vaccines, 2021
Novel tuberculosis (TB)-vaccines preferably should (i) boost host immune responses induced by previous BCG vaccination and (ii) be directed against Mycobacterium tuberculosis (Mtb) proteins expressed throughout the Mtb infection-cycle.
Mariateresa Coppola, Fabienne Jurion, Susan J. F. van den Eeden, Hermann Giresse Tima, Kees L. M. C. Franken, Annemieke Geluk, Marta Romano, Tom H. M. Ottenhoff   +7 more
doaj   +1 more source

A Multiomics Approach Unravels New Toxins With Possible In Silico Antimicrobial, Antiviral, and Antitumoral Activities in the Venom of Acanthoscurria rondoniae

Frontiers in Pharmacology, 2020
The Araneae order is considered one of the most successful groups among venomous animals in the world. An important factor for this success is the production of venoms, a refined biological fluid rich in proteins, short peptides and cysteine-rich ...
Guilherme A. Câmara, Milton Y. Nishiyama-Jr, Eduardo S. Kitano, Ursula C. Oliveira, Pedro I. da Silva, Inácio L. Junqueira-de-Azevedo, Alexandre K. Tashima, Alexandre K. Tashima   +7 more
doaj   +1 more source

Obstructive Sleep Apnea Monocytes Exhibit High Levels of Vascular Endothelial Growth Factor Secretion, Augmenting Tumor Progression

Mediators of Inflammation, 2018
Obstructive sleep apnea (OSA) is a syndrome characterized by repeated pauses in breathing induced by a partial or complete collapse of the upper airways during sleep.
Carolina Cubillos-Zapata, Enrique Hernández-Jiménez, José Avendaño-Ortiz, Victor Toledano, Anibal Varela-Serrano, Isabel Fernández-Navarro, Raquel Casitas, Carlos Carpio, Luis A. Aguirre, Francisco García-Río, Eduardo López-Collazo   +10 more
doaj   +1 more source

Fibroblast Growth Factor 2 lethally sensitizes cancer cells to stress‐targeted therapeutic inhibitors

Molecular Oncology, 2019
In malignant transformation, cellular stress‐response pathways are dynamically mobilized to counterbalance oncogenic activity, keeping cancer cells viable.
Matheus H. Dias, Cecília S. Fonseca, Julianna D. Zeidler, Layra L. Albuquerque, Marcelo S. daSilva, Eduardo Cararo‐Lopes, Marcelo S. Reis, Vincent Noël, Edmilson O. dosSantos, Ian A. Prior, Hugo A. Armelin   +10 more
doaj   +1 more source

Integrative multiomics analysis of Premolis semirufa caterpillar venom in the search for molecules leading to a joint disease

Scientific Reports, 2021
The joint disease called pararamosis is an occupational disease caused by accidental contact with bristles of the caterpillar Premolis semirufa. The chronic inflammatory process narrows the joint space and causes alterations in bone structure and ...
Giselle Pidde, Milton Y. Nishiyama, Ursula Castro de Oliveira, Isadora M. Villas-Boas, Adriana F. Paes-Leme, Inácio L. Junqueira-de-Azevedo, Rafael Marques-Porto, Carla C. Squaiella-Baptistão, Denise V. Tambourgi   +8 more
doaj   +1 more source

Crosstalk Between ER Stress, Autophagy and Inflammation

Frontiers in Medicine, 2021
The endoplasmic reticulum (ER) is not only responsible for protein synthesis and folding but also plays a critical role in sensing cellular stress and maintaining cellular homeostasis.
Sandhya Chipurupalli, Unni Samavedam, Nirmal Robinson   +2 more
doaj   +1 more source

Clinical Course and Impact of Breaks in Therapy for Children With Relapsed/Refractory Solid Tumors

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Pediatric relapsed or refractory (R/R) solid tumors carry a dismal prognosis, and postrelapse patient experiences are not well described. We present postrelapse outcomes, including number of R/R events and subsequent therapy regimens.
Matthew T. McEvoy, Elizabeth L. Seashore, W. Susan Cheng, Shondra Clay, Jessica A. Casas, Jennifer H. Foster   +5 more
wiley   +1 more source

Rondonin: antimicrobial properties and mechanism of action

FEBS Open Bio, 2021
Infectious diseases are among the major causes of death in the human population. A wide variety of organisms produce antimicrobial peptides (AMPs) as part of their first line of defense.
Katie C. T. Riciluca, Ursula C. Oliveira, Ronaldo Z. Mendonça, José C. Bozelli Junior, Shirley Schreier, Pedro I. daSilva Junior   +5 more
doaj   +1 more source