Results 41 to 50 of about 12,342,164 (400)

p53, cancer and the immune response

Journal of Cell Science, 2020
The importance of cancer-cell-autonomous functions of the tumour suppressor p53 (encoded by TP53) has been established in many studies, but it is now clear that the p53 status of the cancer cell also has a profound impact on the immune response.
J. Blagih, M. D. Buck, K. Vousden
semanticscholar   +1 more source

A Multiomics Approach Unravels New Toxins With Possible In Silico Antimicrobial, Antiviral, and Antitumoral Activities in the Venom of Acanthoscurria rondoniae

Frontiers in Pharmacology, 2020
The Araneae order is considered one of the most successful groups among venomous animals in the world. An important factor for this success is the production of venoms, a refined biological fluid rich in proteins, short peptides and cysteine-rich ...
Guilherme A. Câmara, Milton Y. Nishiyama-Jr, Eduardo S. Kitano, Ursula C. Oliveira, Pedro I. da Silva, Inácio L. Junqueira-de-Azevedo, Alexandre K. Tashima, Alexandre K. Tashima   +7 more
doaj   +1 more source

Integrative multiomics analysis of Premolis semirufa caterpillar venom in the search for molecules leading to a joint disease

Scientific Reports, 2021
The joint disease called pararamosis is an occupational disease caused by accidental contact with bristles of the caterpillar Premolis semirufa. The chronic inflammatory process narrows the joint space and causes alterations in bone structure and ...
Giselle Pidde, Milton Y. Nishiyama, Ursula Castro de Oliveira, Isadora M. Villas-Boas, Adriana F. Paes-Leme, Inácio L. Junqueira-de-Azevedo, Rafael Marques-Porto, Carla C. Squaiella-Baptistão, Denise V. Tambourgi   +8 more
doaj   +1 more source

Global analysis of gene expression reveals mRNA superinduction is required for the inducible immune response to a bacterial pathogen. [PDF]

, 2017
The inducible innate immune response to infection requires a concerted process of gene expression that is regulated at multiple levels. Most global analyses of the innate immune response have focused on transcription induced by defined immunostimulatory ...
Barry, Kevin C, Ingolia, Nicholas T, Vance, Russell E   +2 more
core   +3 more sources

CXCR4 inhibition in human pancreatic and colorectal cancers induces an integrated immune response

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Patients with microsatellite stable (MSS) pancreatic (PDA) or colorectal cancer (CRC) do not respond to immunotherapy with inhibitors of T cell checkpoints. A possible explanation is suggested by finding that cancer cells in these tumors are
D. Biasci, M. Smoragiewicz, Claire M. Connell, Zhikai Wang, Ya Gao, James E. D. Thaventhiran, B. Basu, Lukasz Magiera, Isaac T. Johnson, L. Bax, A. Gopinathan, Christopher Isherwood, F. Gallagher, M. Pawula, I. Hudecova, D. Gale, N. Rosenfeld, P. Barmpounakis, E. Popa, R. Brais, E. Godfrey, Fraz A Mir, F. Richards, D. Fearon, T. Janowitz, D. Jodrell   +25 more
semanticscholar   +1 more source

Molecular mimicry, genetic homology, and gene sharing proteomic “molecular fingerprints” using an EBV (Epstein-Barr virus)-derived microarray as a potential diagnostic method in autoimmune disease [PDF]

, 2018
EBV (Epstein-Barr Virus) and other human DNA viruses are associated with autoimmune syndromes in epidemiologic studies. In this work, immunoglobulin G response to EBV-encoded proteins which share regions with human immune response proteins from the human
Alessandra Farina, Giuseppina, Dreyfus, David H., FARINA, Antonella   +2 more
core   +1 more source

Remodeling of the Immune Response With Aging: Immunosenescence and Its Potential Impact on COVID-19 Immune Response

Frontiers in Immunology, 2020
Elderly individuals are the most susceptible to an aggressive form of coronavirus disease (COVID-19), caused by SARS-CoV-2. The remodeling of immune response that is observed among the elderly could explain, at least in part, the age gradient in ...
L. L. Cunha, S. Perazzio, J. Azzi, P. Cravedi, L. Riella   +4 more
semanticscholar   +1 more source

Rondonin: antimicrobial properties and mechanism of action

FEBS Open Bio, 2021
Infectious diseases are among the major causes of death in the human population. A wide variety of organisms produce antimicrobial peptides (AMPs) as part of their first line of defense.
Katie C. T. Riciluca, Ursula C. Oliveira, Ronaldo Z. Mendonça, José C. Bozelli Junior, Shirley Schreier, Pedro I. daSilva Junior   +5 more
doaj   +1 more source

Comparative immune responses against Psoroptes ovis in two cattle breeds with different susceptibility to mange [PDF]

, 2015
The sheep scab mite, Psoroptes ovis, is a major problem in the beef cattle industry, especially in Belgian Blue (BB) cattle. This breed is naturally more predisposed to psoroptic mange but reasons for this high susceptibility remain unknown.
Chiers, Koen, Claerebout, Edwin, Geldhof, Peter, González Hernández, Ana, Grauwet, Korneel, Grit, Grietje, Sarre, Charlotte, Van Coppernolle, Stefanie, Van Den Broeck, Wim, Van Meulder, Frederik   +9 more
core   +4 more sources

Manipulation of the Innate Immune Response by Varicella Zoster Virus

Frontiers in Immunology, 2020
Varicella zoster virus (VZV) is the causative agent of chickenpox (varicella) and shingles (herpes zoster). VZV and other members of the herpesvirus family are distinguished by their ability to establish a latent infection, with the potential to ...
Chelsea Gerada, T. Campbell, J. J. Kennedy, Brian P Mcsharry, M. Steain, B. Slobedman, A. Abendroth   +6 more
semanticscholar   +1 more source