Results 101 to 110 of about 3,197,655 (339)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Development of a quality-of-life questionnaire for patients with primary immunodeficiency (QL PID)
Клиническая и специальная психологияContext and relevance. The article highlights the problem of diagnosing the quality of life in patients with primary immunodeficiency (PID), genetic disorders of immunity characterized by defects in immune defense mechanisms.
Z.A. Abramyan +4 more
doaj +1 more source
The effect of short term feeding with organic and conventional diets on selected immune parameters in rat [PDF]
, 2007 There is currently no evidence for beneficial health impacts being associated with the consumption of organic rather than conventional foods. This preliminary study was therefore aimed at using haematological parameters, white blood cell (WBC) number and
Baranska, A. +5 more
core
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Frontiers in NeurologyBackgroundPrevious genetic and epidemiological studies have examined subpopulations from the Canadian Collaborative Project on Genetic Susceptibility to Multiple Sclerosis (CCPGSMS) patient cohort, but an encompassing analysis of the study population has
Alison M. Pagalilauan +14 more
doaj +1 more source
Chronic wounds alter the proteome profile in skin mucus of farmed gilthead seabream
BMC Genomics, 2017 Background Skin and its mucus are known to be the first barrier of defence against any external stressors. In fish, skin wounds frequently appear as a result of intensive culture and also some diseases have skin ulcers as external clinical signs. However,
Héctor Cordero +3 more
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
An Artificial Immune System Model for Multi-Agents Resource Sharing in Distributed Environments [PDF]
, 2011 Tejbanta Singh Chingtham +2 more
openalex +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair
Nature Communications, 2016 Antigen receptor diversity relies on careful DNA cleavage and repair. Here the authors identify a functional interplay between RAG2 and XLF during V(D)J recombination, revealing an important role for the RAG complex in repairing induced DNA double-strand
Chloé Lescale +8 more
doaj +1 more source