Results 81 to 90 of about 20,886,142 (305)

The Antarctic Wintering Alters the Properties of Human Plasma Cell-Free DNA

Biochemistry Research International
Extracellular DNA of blood plasma (cell-free DNA, cfDNA) may potentially indicate a total level of apoptosis and mediate the immune response to stress induced by extreme environmental conditions, such as Antarctic wintering.
Sergey Ponomarev, Anastasia Kotikova, Nikolay Osetsky, Natalia Veiko, Elizaveta Ershova, Elena Malinovskaya, Ekaterina Savinova, Julia Chudakova, Julia Eliseeva, Vera Izhevskaia, Sergey Kutsev, Svetlana Kostyuk   +11 more
doaj   +1 more source

Cernunnos/Xlf Deficiency Results in Suboptimal V(D)J Recombination and Impaired Lymphoid Development in Mice

Frontiers in Immunology, 2019
Xlf/Cernunnos is unique among the core factors of the non-homologous end joining (NHEJ) DNA double strand breaks (DSBs) repair pathway, in the sense that it is not essential for V(D)J recombination in vivo and in vitro.
Benoit Roch, Benoit Roch, Vincent Abramowski, Vincent Abramowski, Julie Chaumeil, Jean-Pierre de Villartay, Jean-Pierre de Villartay   +6 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Revisiting Hyaluronan Catabolism in Bacteroides: Pathway Conservation, Overlooked Proteins, and Predictive Accuracy

MicrobiologyOpen
The ability of gut microbes to degrade host‐ and diet‐derived glycans is central to microbiome ecology and host interactions, yet predicting these functions in silico remains challenging.
Martin Sindelar, Anna Kocurkova, Matej Simek, Pavel Roudnicky, Gabriela Ambrozova, Lukas Kubala, Kristyna Turkova   +6 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

On Parameter Adjustment of the Immune Inspired Machine Learning Algorithm AINE [PDF]

, 2000
A machine-learning algorithm based on the natural immune system metaphor has been developed, AINE (Artificial Immune Network). AINE developed from initial work on Artificial Immune Systems for data analysis, for which detailed experimentation was ...
Timmis, Jon
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Exploiting Immunological Properties for Ubiqitous Computing Systems [PDF]

, 2004
The immune system exhibits properties such as learning, distributivity continual adaptation, context dependent response and memory during the lifetime of a host.
Timmis, Jon, Philipp H. Mohr, Mohr, Philipp H., Ryan, Nick S., Jon Timmis, Nick Ryan   +5 more
core   +1 more source

Chaperone-mediated MHC-I peptide exchange in antigen presentation

IUCrJ
This work focuses on molecules that are encoded by the major histocompatibility complex (MHC) and that bind self-, foreign- or tumor-derived peptides and display these at the cell surface for recognition by receptors on T lymphocytes (T cell receptors ...
Jiansheng Jiang, Kannan Natarajan, David H. Margulies   +2 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source