Results 11 to 20 of about 3,079,330 (346)
Ubiquitin in the immune system [PDF]
EMBO reports, 2013 Ubiquitination is a post-translational modification process that has been implicated in the regulation of innate and adaptive immune responses. There is increasing evidence that both ubiquitination and its reversal, deubiquitination, play crucial roles not only during the development of the immune system but also in the orchestration of an immune ...
Zinngrebe Julia +3 more
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Systemic immunity in cancer [PDF]
Nature Reviews Cancer, 2021 Immunotherapy has revolutionized cancer treatment, but efficacy remains limited in most clinical settings. Cancer is a systemic disease that induces many functional and compositional changes to the immune system as a whole. Immunity is regulated by interactions of diverse cell lineages across tissues.
Kamir J. Hiam-Galvez +2 more
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The immune system as a system of relations
Frontiers in Immunology, 2022 Progress in neuroimmunology established that the nervous and the immune systems are two functionally related physiological systems. Unique sensory and immune receptors enable them to control interactions of the organism with the inner and the outer worlds. Both systems undergo an experience-driven selection process during their ontogeny. They share the
Marc Daëron, Marc Daëron, Marc Daëron
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Essays in Biochemistry, 2016 All organisms are connected in a complex web of relationships. Although many of these are benign, not all are, and everything alive devotes significant resources to identifying and neutralizing threats from other species. From bacteria through to primates, the presence of some kind of effective immune system has gone hand in hand with evolutionary ...
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PlGF, immune system and hypertension [PDF]
, 2015 The huge diffusion of hypertension and its associated complications has a significant impact on public health [1]. However, despite the high prevalence of essential hypertension and many efforts of research, the basic pathophysiological causes remain
CARNEVALE, DANIELA, LEMBO, Giuseppe
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Autophagy in the immune system [PDF]
Immunology, 2013 SummaryAutophagy is an intracellular homeostatic mechanism important for the degradation of waste components from the cytoplasm in acidic lysosomal compartments. Originally, surplus parts of the cytoplasm that acted as targets for autophagy were thought to comprise cellular organelles and proteins, but this has now extended to include a range of ...
Daniel J. Puleston +2 more
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PI3K in T Cell Adhesion and Trafficking
Frontiers in Immunology, 2021 PI3K signalling is required for activation, differentiation, and trafficking of T cells. PI3Kδ, the dominant PI3K isoform in T cells, has been extensively characterised using PI3Kδ mutant mouse models and PI3K inhibitors. Furthermore, characterisation of
Kristoffer H. Johansen +5 more
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An Immune Inspired Approach to Anomaly Detection [PDF]
, 2007 The immune system provides a rich metaphor for computer security: anomaly detection that works in nature should work for machines. However, early artificial immune system approaches for computer security had only limited success.
Aickelin, Uwe, Twycross, Jamie
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Structural mechanism of tapasin-mediated MHC-I peptide loading in antigen presentation
Nature Communications, 2022 The catalytic chaperone tapasin assists peptide loading onto MHC-I molecules for antigen presentation and immune recognition. Here, the authors present crystal structures that provide insights into the molecular mechanism of tapasin-mediated peptide ...
Jiansheng Jiang +11 more
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Frontiers in Immunology, 2014 Natural killer (NK) cells play an essential role in the fight against tumor development. Over the last years, the progress made in the NK cell biology field and in deciphering how NK cell function is regulated, is driving efforts to utilize NK cell-based
Cristina eEguizabal +11 more
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