Results 11 to 20 of about 25,098,294 (334)
Frontiers in Immunology, 2022 Podocalyxin (PODXL), a cell surface sialomucin expressed in diverse types of normal and malignant cells, mediates cellular adhesion to extracellular matrix and cell-to-cell interaction.
Laura Amo +4 more
doaj +1 more source
Mapping the developing human immune system across organs
bioRxiv, 2022 Recent advances in single cell genomics technologies have facilitated studies on the developing immune system at unprecedented scale and resolution. However, these studies have focused on one or a few organs and were thus limited in understanding the ...
Chenqu Suo +25 more
semanticscholar +1 more source
Regulatory T cells decrease C3-positive reactive astrocytes in Alzheimer-like pathology
Journal of Neuroinflammation, 2023 Background Increasing evidence supports a key role for peripheral immune processes in the pathophysiology of Alzheimer’s disease (AD), highlighting an intricate interplay between brain resident glial cells and both innate and adaptive peripheral immune ...
Grégoire Stym-Popper +8 more
doaj +1 more source
The Role of Minerals in the Optimal Functioning of the Immune System
Nutrients, 2022 Minerals fulfil a wide variety of functions in the optimal functioning of the immune system. This review reports on the minerals that are essential for the immune system’s function and inflammation regulation.
C. Weyh +3 more
semanticscholar +1 more source
A Review of Micronutrients and the Immune System–Working in Harmony to Reduce the Risk of Infection
Nutrients, 2020 Immune support by micronutrients is historically based on vitamin C deficiency and supplementation in scurvy in early times. It has since been established that the complex, integrated immune system needs multiple specific micronutrients, including ...
A. Gombart, A. Pierre, S. Maggini
semanticscholar +1 more source
Scientific Reports, 2023 MARCKS (myristoylated alanine-rich C-kinase substrate) is a membrane-associated protein expressed in many cell types, including macrophages. MARCKS is functionally implicated in cell adhesion, phagocytosis, and inflammation.
Jiraphorn Issara-Amphorn +6 more
doaj +1 more source
PI3K in T Cell Adhesion and Trafficking
Frontiers in Immunology, 2021 PI3K signalling is required for activation, differentiation, and trafficking of T cells. PI3Kδ, the dominant PI3K isoform in T cells, has been extensively characterised using PI3Kδ mutant mouse models and PI3K inhibitors. Furthermore, characterisation of
Kristoffer H. Johansen +5 more
doaj +1 more source
Nutrients, 2020 The coronavirus-disease 2019 (COVID-19) was announced as a global pandemic by the World Health Organization. Challenges arise concerning how to optimally support the immune system in the general population, especially under self-confinement.
M. Iddir +6 more
semanticscholar +1 more source
Structural mechanism of tapasin-mediated MHC-I peptide loading in antigen presentation
Nature Communications, 2022 The catalytic chaperone tapasin assists peptide loading onto MHC-I molecules for antigen presentation and immune recognition. Here, the authors present crystal structures that provide insights into the molecular mechanism of tapasin-mediated peptide ...
Jiansheng Jiang +11 more
doaj +1 more source
Peripheral and central immune system crosstalk in Alzheimer disease — a research prospectus
Nature Reviews Neurology, 2021 Dysregulation of the immune system is a cardinal feature of Alzheimer disease (AD), and a considerable body of evidence indicates pathological alterations in central and peripheral immune responses that change over time.
Brianne M. Bettcher +3 more
semanticscholar +1 more source