Results 81 to 90 of about 25,098,294 (334)

Chronic wounds alter the proteome profile in skin mucus of farmed gilthead seabream

open access: yesBMC Genomics, 2017
Background Skin and its mucus are known to be the first barrier of defence against any external stressors. In fish, skin wounds frequently appear as a result of intensive culture and also some diseases have skin ulcers as external clinical signs. However,
Héctor Cordero   +3 more
doaj   +1 more source

Sexual-dimorphism in human immune system aging

open access: yesNature Communications, 2019
Differences in immune function and responses contribute to health- and life-span disparities between sexes. However, the role of sex in immune system aging is not well understood.
E. Márquez   +9 more
semanticscholar   +1 more source

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

open access: yesMolecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever   +1 more
wiley   +1 more source

Two novel immunization strategies for epidemic control in directed scale-free networks with nonlinear infectivity [PDF]

open access: yesarXiv, 2018
In this paper, we propose two novel immunization strategies, i.e., combined immunization and duplex immunization, for SIS model in directed scale-free networks, and obtain the epidemic thresholds for them with linear and nonlinear infectivities. With the suggested two new strategies, the epidemic thresholds after immunization are greatly increased. For
arxiv  

Small-molecule screening identifies Syk kinase inhibition and rutaecarpine as modulators of macrophage training and SARS-CoV-2 infection

open access: yesCell Reports, 2022
Summary: Biologically active small molecules can impart modulatory effects, in some cases providing extended long-term memory. In a screen of biologically active small molecules for regulators of tumor necrosis factor (TNF) induction, we identify several
Sinu P. John   +13 more
doaj  

Beneficial Effects of Probiotic Consumption on the Immune System

open access: yesAnnals of Nutrition and Metabolism, 2019
Background: The gastrointestinal tract is one of the most microbiologically active ecosystems that plays a crucial role in the working of the mucosal immune system (MIS). In this ecosystem, the consumed probiotics stimulate the immune system and induce a
C. Maldonado Galdeano   +4 more
semanticscholar   +1 more source

Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink   +6 more
wiley   +1 more source

Immuno-epidemiology of a population structured by immune status: a mathematical study of waning immunity and immune system boosting [PDF]

open access: yesarXiv, 2014
When the body gets infected by a pathogen the immune system develops pathogen-specific immunity. Induced immunity decays in time and years after recovery the host might become susceptible again. Exposure to the pathogen in the environment boosts the immune system thus prolonging the time in which a recovered individual is immune.
arxiv  

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

open access: yesMolecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi   +3 more
wiley   +1 more source

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