Results 91 to 100 of about 3,483,015 (354)
Towards early diagnosis of Alzheimer's disease: Advances in immune-related blood biomarkers and computational modeling approaches [PDF]
arXiv, 2023 Alzheimer's disease has an increasing prevalence in the population world-wide, yet current diagnostic methods based on recommended biomarkers are only available in specialized clinics. Due to these circumstances, Alzheimer's disease is usually diagnosed late, which contrasts with the currently available treatment options that are only effective for ...
arxiv
Peripheral immune system in aging and Alzheimer’s disease [PDF]
Molecular Neurodegeneration, 2018 Alzheimer's disease (AD) represents an urgent public health mandate. AD is no longer considered a neural-centric disease; rather, a plethora of recent studies strongly implicate a critical role played by neuroinflammation in the pathogeneses of AD and other neurodegenerative conditions.
Wei Cao, Hui Zheng
openaire +4 more sources
Aging-induced fragility of the immune system [PDF]
arXiv, 2020 The adaptive and innate branches of the vertebrate immune system work in close collaboration to protect organisms from harmful pathogens. As an organism ages its immune system undergoes immunosenescence, characterized by declined performance or malfunction in either immune branch, which can lead to disease and death.
arxiv
Glassy Dynamics in the Adaptive Immune Response Prevents Autoimmune Disease [PDF]
, 2005 The immune system normally protects the human host against death by infection. However, when an immune response is mistakenly directed at self antigens, autoimmune disease can occur. We describe a model of protein evolution to simulate the dynamics of the adaptive immune response to antigens.
arxiv +1 more source
A Perturbative Approach to the Analysis of Many-Compartment Models Characterized by the Presence of Waning Immunity [PDF]
arXiv, 2021 The waning of immunity after recovery or vaccination is a major factor accounting for the severity and prolonged duration of an array of epidemics, ranging from COVID-19 to diphtheria and pertussis. To study the effectiveness of different immunity level-based vaccination schemes in mitigating the impact of waning immunity, we construct epidemiological ...
arxiv
Effect of Salivary Exosomal miR-25-3p on Periodontitis With Insulin Resistance
Frontiers in Immunology, 2022 Periodontitis is caused by an oral microbial dysbiosis-mediated imbalance of the local immune microenvironment, which is promoted by insulin resistance and obesity.
Jin-Seok Byun +15 more
doaj +1 more source
Beyond Vaccination Rates: A Synthetic Random Proxy Metric of Total SARS-CoV-2 Immunity Seroprevalence in the Community [PDF]
arXiv, 2022 Explicit knowledge of total community-level immune seroprevalence is critical to developing policies to mitigate the social and clinical impact of SARS-CoV-2. Publicly available vaccination data are frequently cited as a proxy for population immunity, but this metric ignores the effects of naturally-acquired immunity, which varies broadly throughout ...
arxiv
Effects of viral and cytokine delays on dynamics of autoimmunity [PDF]
Mathematics 6, 66 (2018), 2018 A major contribution to the onset and development of autoimmune disease is known to come from infections. An important practical problem is identifying the precise mechanism by which the breakdown of immune tolerance as a result of immune response to infection leads to autoimmunity. In this paper, we develop a mathematical model of immune response to a
arxiv +1 more source
CNS and CNS diseases in relation to their immune system
Frontiers in Immunology, 2022 The central nervous system is the most important nervous system in vertebrates, which is responsible for transmitting information to the peripheral nervous system and controlling the body’s activities. It mainly consists of the brain and spinal cord, which contains rich of neurons, the precision of the neural structures susceptible to damage from the ...
Jianhao Xu +5 more
openaire +3 more sources
Frontiers in NeurologyBackgroundPrevious genetic and epidemiological studies have examined subpopulations from the Canadian Collaborative Project on Genetic Susceptibility to Multiple Sclerosis (CCPGSMS) patient cohort, but an encompassing analysis of the study population has
Alison M. Pagalilauan +14 more
doaj +1 more source