Results 81 to 90 of about 3,483,015 (354)

The Off-Label Use of Antineoplastics in Oncology Is Limited But Has Notable Scientific Support in a University Hospital Setting

Frontiers in Pharmacology, 2019
Purpose: The off-label (OL) use of antineoplastic drugs for the treatment of various types of tumors in patients of different disease stages is becoming a common occurrence.
Marta Herrero Fernandez, Raquel Molina Villaverde, Raquel Molina Villaverde, Raquel Molina Villaverde, Monica Arroyo Yustos, Monica Arroyo Yustos, Monica Arroyo Yustos, Fatima Navarro Expósito, Fatima Navarro Expósito, Fatima Navarro Expósito, Jose Luis Lopez Gonzalez, Jose Luis Lopez Gonzalez, Jose Luis Lopez Gonzalez, Maria Rosario Luque Infantes, Melchor Alvarez-Mon Soto, Melchor Alvarez-Mon Soto, Melchor Alvarez-Mon Soto   +16 more
doaj   +1 more source

Potential Therapeutic Anti-Inflammatory and Immunomodulatory Effects of Dihydroflavones, Flavones, and Flavonols

Molecules, 2020
Systemic inflammation, circulating immune cell activation, and endothelial cell damage play a critical role in vascular pathogenesis. Flavonoids have shown anti-inflammatory effects.
Cristina Zaragozá, Lucinda Villaescusa, Jorge Monserrat, Francisco Zaragozá, Melchor Álvarez-Mon   +4 more
doaj   +1 more source

A syndrome featuring developmental disorder of the nervous system induced by a novel mutation in the TCF20 gene, rarely concurrent immune disorders: a case report

Frontiers in Genetics, 2023
Background: The expression of TCF20 is the most widespread in brain tissue. TCF20 depletion or mutation can affect the proliferation and differentiation of embryonic neurons, leading to developmental disorder of the central nervous system and subsequent ...
Si Huang, Si Huang, Si Huang, Si Huang, Jiaxin Xu, Yiyang Li, Wenhui Mo, Xiuwen Lin, Yajun Wang, Yajun Wang, Yajun Wang, Fujian Liang, Yan Bai, Guochun Huang, Jing Chen, Jing Xin, Guoda Ma, Guoda Ma, Guoda Ma   +18 more
doaj   +1 more source

The Effect of Vaccination on the Competitive Advantage of Two Strains of an Infectious Disease [PDF]

arXiv, 2023
We investigate how a population's natural and vaccine immunity affects the competitive balance between two strains of an infectious disease with different epidemiological characteristics. Specifically, we consider the case where one strain is more transmissible and the other strain is more immune-resistant.
arxiv  

Parkinson’s Disease and the Immune System

, 2012
The characteristic neuropathological markers of PD are the presence of Lewy bodies, containing modified alpha-synuclein amongst other proteins, in the surviving neurons, and the degeneration of neuromelanin-containing, dopaminergic neurons in the substance nigra pas compact region of the brain. In addition, the progressive nature of PD is characterized
David T. Dexter, Roberta J. Ward, Robert Crichton   +2 more
openaire   +4 more sources

Reprogramming of Polycomb-Mediated Gene Silencing in Embryonic Stem Cells by the miR-290 Family and the Methyltransferase Ash1l

Stem Cell Reports, 2015
Members of the miR-290 family are the most abundantly expressed microRNAs (miRNAs) in mouse embryonic stem cells (ESCs). They regulate aspects of differentiation, pluripotency, and proliferation of ESCs, but the molecular program that they control has ...
Chryssa Kanellopoulou, Timothy Gilpatrick, Gokhul Kilaru, Patrick Burr, Cuong K. Nguyen, Aaron Morawski, Michael J. Lenardo, Stefan A. Muljo   +7 more
doaj   +1 more source

A two-strain model of infectious disease spread with asymmetric temporary immunity periods and partial cross-immunity [PDF]

arXiv, 2023
We introduce a two-strain model with asymmetric temporary immunity periods and partial cross-immunity. We derive explicit conditions for competitive exclusion and coexistence of the strains depending on the strain-specific basic reproduction numbers, temporary immunity periods, and degree of cross-immunity.
arxiv  

Disruption of the Interaction between ORF33 and the Conserved Carboxyl-Terminus of ORF45 Abolishes Progeny Virion Production of Kaposi Sarcoma-Associated Herpesvirus

Viruses, 2021
The Open Reading Frame 45 (ORF45) of Kaposi sarcoma-associated herpesvirus (KSHV) is a gammaherpesvirus-specific, immediate-early, tegument protein required for efficient viral replication and virion production.
Joseph Gillen, Fanxiu Zhu
doaj   +1 more source

The Endocannabinoid System in Pediatric Inflammatory and Immune Diseases [PDF]

International Journal of Molecular Sciences, 2019
Endocannabinoid system consists of cannabinoid type 1 (CB1) and cannabinoid type 2 (CB2) receptors, their endogenous ligands, and the enzymes responsible for their synthesis and degradation. CB2, to a great extent, and CB1, to a lesser extent, are involved in regulating the immune response.
Maura Argenziano 1, Chiara Tortora 2, Giulia Bellini 1, Alessandra Di Paola 1, Francesca Punzo, Francesca Rossi   +5 more
openaire   +2 more sources

Correlations in the T Cell Response to Altered Peptide Ligands [PDF]

, 2004
The vertebrate immune system is a wonder of modern evolution. Occasionally, however, correlations within the immune system lead to inappropriate recruitment of preexisting T cells against novel viral diseases. We present a random energy theory for the correlations in the naive and memory T cell immune responses.
arxiv   +1 more source