Results 81 to 90 of about 3,492,274 (391)

A syndrome featuring developmental disorder of the nervous system induced by a novel mutation in the TCF20 gene, rarely concurrent immune disorders: a case report

Frontiers in Genetics, 2023
Background: The expression of TCF20 is the most widespread in brain tissue. TCF20 depletion or mutation can affect the proliferation and differentiation of embryonic neurons, leading to developmental disorder of the central nervous system and subsequent ...
Si Huang, Si Huang, Si Huang, Si Huang, Jiaxin Xu, Yiyang Li, Wenhui Mo, Xiuwen Lin, Yajun Wang, Yajun Wang, Yajun Wang, Fujian Liang, Yan Bai, Guochun Huang, Jing Chen, Jing Xin, Guoda Ma, Guoda Ma, Guoda Ma   +18 more
doaj   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

The Off-Label Use of Antineoplastics in Oncology Is Limited But Has Notable Scientific Support in a University Hospital Setting

Frontiers in Pharmacology, 2019
Purpose: The off-label (OL) use of antineoplastic drugs for the treatment of various types of tumors in patients of different disease stages is becoming a common occurrence.
Marta Herrero Fernandez, Raquel Molina Villaverde, Raquel Molina Villaverde, Raquel Molina Villaverde, Monica Arroyo Yustos, Monica Arroyo Yustos, Monica Arroyo Yustos, Fatima Navarro Expósito, Fatima Navarro Expósito, Fatima Navarro Expósito, Jose Luis Lopez Gonzalez, Jose Luis Lopez Gonzalez, Jose Luis Lopez Gonzalez, Maria Rosario Luque Infantes, Melchor Alvarez-Mon Soto, Melchor Alvarez-Mon Soto, Melchor Alvarez-Mon Soto   +16 more
doaj   +1 more source

Current and Emerging Pharmacotherapeutic Interventions for the Treatment of Peripheral Nerve Disorders

Pharmaceuticals, 2022
Peripheral nerve disorders are caused by a range of different aetiologies. The range of causes include metabolic conditions such as diabetes, obesity and chronic kidney disease.
Jeremy Chung Bo Chiang, Ria Arnold, Roshan Dhanapalaratnam, Maria Markoulli, Arun V. Krishnan   +4 more
doaj   +1 more source

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

The Immune System [PDF]

, 1995
Modern biotherapy has been in use for some 30 years. The first types of biotherapy were nonspecific stimulators of the immune response, but advances in genetic engineering are allowing the mass production of pure biological products which are now being ...
Gallucci, Betty Bierut, McCarthy, Donna O.   +1 more
core   +1 more source

Epi-drugs in combination with immunotherapy: a new avenue to improve anticancer efficacy [PDF]

, 2017
Immune checkpoint factors, such as programmed cell death protein-1/2 (PD-1, PD-2) or cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) receptors, are targets for monoclonal antibodies (MAbs) developed for cancer immunotherapy.
Mai, Antonello, Mazzone, Roberta, Valente, Sergio, Zwergel, Clemens   +3 more
core   +1 more source

Reprogramming of Polycomb-Mediated Gene Silencing in Embryonic Stem Cells by the miR-290 Family and the Methyltransferase Ash1l

Stem Cell Reports, 2015
Members of the miR-290 family are the most abundantly expressed microRNAs (miRNAs) in mouse embryonic stem cells (ESCs). They regulate aspects of differentiation, pluripotency, and proliferation of ESCs, but the molecular program that they control has ...
Chryssa Kanellopoulou, Timothy Gilpatrick, Gokhul Kilaru, Patrick Burr, Cuong K. Nguyen, Aaron Morawski, Michael J. Lenardo, Stefan A. Muljo   +7 more
doaj   +1 more source

Parkinson’s Disease and the Immune System

, 2012
The characteristic neuropathological markers of PD are the presence of Lewy bodies, containing modified alpha-synuclein amongst other proteins, in the surviving neurons, and the degeneration of neuromelanin-containing, dopaminergic neurons in the substance nigra pas compact region of the brain. In addition, the progressive nature of PD is characterized
David T. Dexter, Roberta J. Ward, Robert Crichton   +2 more
openaire   +4 more sources

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source