Results 41 to 50 of about 280,275 (267)
Concept of trayopstambha in preventing autoimmune disorders
Environment Conservation Journal, 2019 Three supporting factors of life i.e., Ahara, Swapan and Brahmacharya are known as Trayopstambha. These are the three major pillars which balance the Vata, Pitta and Kapha dosha in our body. Auto immune disorder is a disease of immune system in which our
Neha Shah, Amita Jhunjhunwala
doaj +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Understanding Multicellularity: The Functional Organization of the Intercellular Space [PDF]
, 2019 The aim of this paper is to provide a theoretical framework to understand how multicellular systems realize functionally integrated physiological entities by organizing their intercellular space. From a perspective centered on physiology and integration,
Bich, Leonardo +2 more
core +10 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
, 2006 We investigate a stochastic version of a simple enzymatic reaction which follows the generic Michaelis-Menten kinetics. At sufficiently high concentrations of reacting species, the molecular fluctuations can be approximated as a realization of a Brownian
A. Ochab-Marcinek +14 more
core +1 more source
Noise in multiple sclerosis: unwanted and necessary [PDF]
, 2014 As our knowledge about the etiology of multiple sclerosis (MS) increases, deterministic paradigms appear insufficient to describe the pathogenesis of the disease, and the impression is that stochastic phenomena (i.e.
BORDI, Isabella +7 more
core +1 more source
Molecular Oncology, EarlyView.In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern +7 more
wiley +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Propagation and Decay of Injected One-Off Delays on Clusters: A Case Study
, 2019 Analytic, first-principles performance modeling of distributed-memory applications is difficult due to a wide spectrum of random disturbances caused by the application and the system.
Afzal, Ayesha +2 more
core +1 more source
Cyclic β-glucans at the bacteria–host cells interphase: One sugar ring to rule them all [PDF]
, 2018 Cyclic β‐1,2‐D‐glucans (CβG) are natural bionanopolymers present in the periplasmic space of many Proteobacteria. These molecules are sugar rings made of 17 to 25 D‐glucose units linked exclusively by β‐1,2‐glycosidic bonds.
Arce Gorvel, Vilma +4 more
core +1 more source