Platelet-Induced Clumping of Plasmodium falciparum–Infected Erythrocytes from Malawian Patients with Cerebral Malaria—Possible Modulation In Vivo by Thrombocytopenia [PDF]
, 2008 Platelets may play a role in the pathogenesis of human cerebral malaria (CM), and they have been shown to induce clumping of Plasmodium falciparum–parasitized red blood cells (PRBCs) in vitro.
Barnwell JW +18 more
core +1 more source
Hodgkin's lymphoma presenting as immune thrombocytopenia
Indian Journal of Medical and Paediatric Oncology, 2019 Immune thrombocytopenia (ITP) in lymphoid malignancies has been observed primarily in relation to chronic lymphoproliferative disorders. ITP in Hodgkin's lymphoma (HL) is a rare presentation, most often reported at follow-up.
Mili Jain +3 more
doaj +1 more source
Two novel immunization strategies for epidemic control in directed scale-free networks with nonlinear infectivity [PDF]
arXiv, 2018 In this paper, we propose two novel immunization strategies, i.e., combined immunization and duplex immunization, for SIS model in directed scale-free networks, and obtain the epidemic thresholds for them with linear and nonlinear infectivities. With the suggested two new strategies, the epidemic thresholds after immunization are greatly increased. For
arxiv
Repurposing metformin for cancer treatment: current clinical studies. [PDF]
, 2016 In recent years, several studies have presented evidence suggesting a potential role for metformin in anti-cancer therapy. Preclinical studies have demonstrated several anticancer molecular mechanisms of metformin including mTOR inhibition, cytotoxic ...
Altman, Jessica K +10 more
core +1 more source
Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2018 BACKGROUND AND OBJECTIVE: Thrombocytopenia is one of the complications of chemotherapy drugs that may cause death. Different animal models of thrombocytopenia are used for clinical research and identification of its causes, each with advantages and ...
H Kamali +3 more
doaj
Haematologica, 2019 Enhanced peripheral complement activation has long been considered as one of the major pathogenic elements of immune thrombocytopenia. A dysfunctional bone marrow microenvironment, especially with regards to mesenchymal stem cells, has been observed in ...
Xiaolu Zhu +12 more
doaj +1 more source
MIF-mediated hemodilution promotes pathogenic anemia in experimental African trypanosomosis [PDF]
, 2016 Animal African trypanosomosis is a major threat to the economic development and human health in sub-Saharan Africa. Trypanosoma congolense infections represent the major constraint in livestock production, with anemia as the major pathogenic lethal ...
Beschin, Alain +17 more
core +5 more sources
Immuno-epidemiology of a population structured by immune status: a mathematical study of waning immunity and immune system boosting [PDF]
arXiv, 2014 When the body gets infected by a pathogen the immune system develops pathogen-specific immunity. Induced immunity decays in time and years after recovery the host might become susceptible again. Exposure to the pathogen in the environment boosts the immune system thus prolonging the time in which a recovered individual is immune.
arxiv
CLINICAL APPLICABILITY OF PROPOSED ALGORITHM FOR IDENTIFYING INDIVIDUALS AT RISK FOR HEREDITARY HEMATOLOGIC MALIGNANCIES [PDF]
, 2017 Over the past decade, more than 12 genes have been identified to cause hereditary predispositions to hematologic malignancies. These syndromes are characterized by an increased risk to develop myelodysplastic syndrome (MDS), acute myeloid leukemia (AML),
Clifford, Maggie
core +1 more source