Results 181 to 190 of about 138,032 (344)

Lipid Nanoparticles Delivering ClpP‐mRNA Suppress Pyroptosis and Senescence in Intervertebral Disc Degeneration via mTOR/BNIP3‐Activated Mitophagy

Rare Metals, EarlyView.
ABSTRACT Intervertebral disc degeneration (IDD) is a predominant cause of low back pain, significantly impacting quality of life. Mitochondrial fitness is essential in the progression of IDD, as it regulates cellular senescence and pyroptosis. This study investigates the role of mitochondrial caseinolytic protease P (ClpP) in alleviating senescence and
Kun Wang, Zhiqiang Wang, Tong Zhang, Shicheng Qiu, Guang Yang, Yanzheng Gao, Xiaofeng Lian, Xin Peng   +7 more
wiley   +1 more source

Clinical characteristics of immediate allergic adverse reactions to intravenous amoxicillin‒clavulanic acid in conscious dogs

Veterinary Record, EarlyView.
Abstract Background Amoxicillin‒clavulanic acid (AMC) is one of the most frequently used antibiotics in small animal practice, and reports on adverse reactions are scarce. The aim of this study was to describe the clinical characteristics of immediate allergic adverse reactions to intravenous (IV) AMC in conscious dogs. Methods The medical records of a
Leonel Frutuoso, Anna Threlfall
wiley   +1 more source

Safety and efficacy of daratumumab in immune thrombocytopenia. [PDF]

Blood Adv
Tsykunova G, Holme PA, Tran HTT, Frederiksen H, Tjønnfjord E, Munthe LA, Drivet E, Kared H, Sørvoll IH, Ahlen MT, Mahévas M, Michel M, Bussel J, Kuter DJ, Anderson Tvedt TH, Ghanima W.   +15 more
europepmc   +1 more source

A novel canine model of immune thrombocytopenia: has immune thrombocytopenia (ITP) gone to the dogs?

, 2014
Dana N. LeVine, Adam J. Birkenheuer, Marjory B. Brooks, Shila K. Nordone, Dwight A. Bellinger, Samuel L. Jones, Thomas Fischer, Stephen E. Oglesbee, Kahlina Frey, Nicole S. Brinson, Allison P. Peters, Henry S. Marr, Alison A. Motsinger‐Reif, Sif Gudbrandsdottir, James B. Bussel, Nigel S. Key   +15 more
openalex   +1 more source

PB2300: COMPLEMENT ACTIVATION NEGATIVELY AFFECTS THE PLATELET RESPONSE TO THROMBOPOIETIN RECEPTOR AGONISTS IN PATIENTS WITH IMMUNE THROMBOCYTOPENIA: A PROSPECTIVE COHORT STUDY

, 2022
A Akesson, James B. Bussel, Myriam Martin, Anna M. Blom, Jenny Klintman, Waleed Ghanima, Eva Zetterberg, Lamya Garabet   +7 more
openalex   +1 more source

Single Cell Analysis Reveals Dynamic Changes of Distinct Cell Populations in Human Nickel Allergy

Allergy, EarlyView.
We investigated cell types mediating the early and late inflammatory responses in human Ni2+‐allergy by scRNA‐Seq. Early responsiveness was mainly mediated by TLR4+TAGLN− endothelial cells indirectly activating TLR4−KRT16+ keratinocytes, and CCR7+DCN+ DCs. Late responsiveness was crucially driven by infiltration of KLF2+ central memory T cells and TLR4+
Marc Schmidt, Andrea Knorz, Katharina Meder, Simon Goller, Fabian Imdahl, Yamila Rocca, Matthias Goebeler, Pierre Khoueiry   +7 more
wiley   +1 more source

Elevated IGF1R and abnormal methylated IGF1R in immune thrombocytopenia. [PDF]

Ann Hematol
Zhu X, Gao N, Li X, Yuan T, Liu Y, Yao Q, Zhang F, Shan N.   +7 more
europepmc   +1 more source

A Case of St-Segment Elevation Myocardial Infarction and Thrombocytopenia Induced by Immune Checkpoint Inhibitor Sintilimab

, 2023
Lijuan Guo, Yuan Chang
openalex   +1 more source

Differential Impact of Polymyxin B Hemadsorption on Long‐Term Mortality in Septic Shock: A Retrospective Analysis of Intra‐Abdominal Versus Extra‐Abdominal Infections

Artificial Organs, EarlyView.
In this single‐center retrospective cohort study, the use of PMX‐HA was significantly associated with a reduced risk of 1‐year mortality in patients with septic shock due to intra‐abdominal infection. In contrast, no significant association was observed between PMX‐HA use and 1‐year mortality risk in patients with septic shock caused by extra‐abdominal
Tomoki Tanaka, Kazunori Fujino, Yasuyuki Tsujita, Yugo Matsumoto, Mitsuhiro Fujino, Hidemitsu Miyatake, Naoto Mizumura, Junji Shimizu, Takuma Kishimoto, Naoto Shiomi   +9 more
wiley   +1 more source

An Umbrella Review of Meta-Analyses on the Efficacy and Safety of Eltrombopag in Immune Thrombocytopenia. [PDF]

Health Sci Rep
Dabir M, Mousavi MK, Manteghi S, Mansoori MA, Karpasand F, Zoghi F, Payandeh M.   +6 more
europepmc   +1 more source