Results 11 to 20 of about 288,299 (272)
Frontiers in Immunology, 2021 CD4+CD25+Foxp3+T cell population is heterogenous and contains three major sub-groups. First, thymus derived T regulatory cells (tTreg) that are naïve/resting. Second, activated/memory Treg that are produced by activation of tTreg by antigen and cytokines.
Bruce M. Hall +17 more
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The Immune Tolerance Network: tolerance at the crossroads [PDF]
Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 2001 Immune tolerance therapies are designed to reprogramme immune cells in a highly specific fashion in order to eliminate pathogenic responses but preserve normal immune function. A concept that has tantalized immunologists for decades, tolerogenic therapies would replace current lifelong immunosuppressive regimens and their often debilitating side ...
Jeffrey Matthe, Jeffrey A. Bluestone
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Advances in Human Immune System Mouse Models for Personalized Treg-Based Immunotherapies
Frontiers in Immunology, 2021 Immunodeficient mice engrafted with a functional human immune system [Human immune system (HIS) mice] have paved the way to major advances for personalized medicine and translation of immune-based therapies.
Isabelle Serr +8 more
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Influence of Innate Immunity on Immune Tolerance
Acta Medica Academica, 2020 This review mainly focuses on the mechanisms of peripheral immune tolerance within the perspectives of innate immunity.Healthy immune response requires balanced interaction of the highly specialized elements of immunity within a harmony. In- nate immunity supported by microbial pattern recognition receptors, physical anatomical barriers and soluble ...
Kucuksezer, Umut C +3 more
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Challenges and Opportunities for Biomarkers of Clinical Response to AHSCT in Autoimmunity
Frontiers in Immunology, 2018 Autoimmunity represents a broad category of diseases that involve a variety of organ targets and distinct autoantigens. For patients with autoimmune diseases who fail to respond to approved disease-modifying treatments, autologous hematopoietic stem cell
Kristina M. Harris +4 more
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Frontiers in Immunology, 2017 ObjectiveTo examine if the protective effect of parasite infection on experimental autoimmune encephalomyelitis (EAE) was due to interleukin (IL)-5, a cytokine produced by a type-2 response that induces eosinophilia.
Giang T. Tran +7 more
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Frontiers in Immunology, 2018 Despite the constant development of innovative therapeutic options for hematological malignancies, the gold-standard therapy regimen for curative treatment often includes allogeneic hematopoietic stem cell transplantation (HSCT).
Nadja Hilger +13 more
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Holy Immune Tolerance, Batman! [PDF]
Immunity, 2018 (Uploaded by Plazi for the Bat Literature Project) Bats are reservoir hosts of numerous viruses that cause severe pathology in humans. How bats cope with such pathogens remains elusive. In a recent issue of Cell, Pavlovich et al. (2018) describe several key adaptations in innate immune-related genes that suggest that the Egyptian rousette fruit bat ...
Luis B. Barreiro, Haley E. Randolph
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The Epitope-Specific Anti-human CD4 Antibody MAX.16H5 and Its Role in Immune Tolerance
Frontiers in Immunology, 2019 T cell modulation in the clinical background of autoimmune diseases or allogeneic cell and organ transplantations with concurrent preservation of their natural immunological functions (e.g., pathogen defense) is the major obstacle in immunology.
Lilly Stahl +4 more
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Changes in Reactivity In Vitro of CD4+CD25+ and CD4+CD25− T Cell Subsets in Transplant Tolerance
Frontiers in Immunology, 2017 Transplant tolerance induced in adult animals is mediated by alloantigen-specific CD4+CD25+ T cells, yet in many models, proliferation of CD4+ T cells from hosts tolerant to specific-alloantigen in vitro is not impaired.
Bruce M. Hall +12 more
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