Results 211 to 220 of about 288,299 (272)

MeCP2 Lactylation Protects against Ischemic Brain Injury by Transcriptionally Regulating Neuronal Apoptosis

Advanced Science, EarlyView.
MeCP2 lactylation protects against ischemic stroke by reducing brain infarct volume and improving neurological outcomes. Lactylation at K210/K249 exerts neuroprotective effects by repressing the transcription of apoptosis‐associated genes, including Pdcd4 and Pla2g6. HDAC3 and p300 serve as key regulatory enzymes for MeCP2 lactylation following stroke.
Min Sun, Yuxin Zhang, Rui Mao, Yan Chen, Pinyi Liu, Lei Ye, Siyi Xu, Junqiu Jia, Shu Shu, Huiya Li, Yanping Yin, Shengnan Xia, Yanting Chen, Yun Xu   +13 more
wiley   +1 more source

Prediction of the chance of successful immune tolerance induction in persons with severe hemophilia A and inhibitors: a clinical prediction model. [PDF]

Res Pract Thromb Haemost
Oomen I, Abdi A, Camelo RM, Callado FMRA, Carvalho LEM, Calcaterra IL, Carcao M, Castaman G, Eikenboom JCJ, Fischer K, Franco VKB, Heymans MW, Leebeek FWG, Lillicrap D, Lorenzato CS, Mancuso ME, Matino D, Di Minno MND, Mohseny AB, Oldenburg J, Rezende SM, Rivard GE, Rydz N, Schols SEM, Voorberg J, Fijnvandraat K, Gouw SC, International Genetic and clinical determinants for the outcome of immune tolerance induction study group.   +27 more
europepmc   +1 more source

Deciphering the Metabolic Impact and Clinical Relevance of N‐Glycosylation in Colorectal Cancer through Comprehensive Glycoproteomic Profiling

Advanced Science, EarlyView.
The comprehensive proteomic and N‐glycoproteomic analyses of 45 colorectal cancer tissues with matched normal adjacent tissues identified 7125 intact N‐glycopeptides from 704 glycoproteins. A glycosylation site‐protein function network revealing metabolic dysregulation is constructed and a model differentiating tumors from normal tissues is developed ...
Guobin Liu, Lu Chen, Jingxiang Zhao, Yue Jiang, Yarong Guo, Xiang Mao, Xuelian Ren, Kun Liu, Qi Mei, Qunyi Li, He Huang   +10 more
wiley   +1 more source

Gut bacteria-derived serotonin promotes immune tolerance in early life. [PDF]

Sci Immunol
Sanidad KZ, Rager SL, Carrow HC, Ananthanarayanan A, Callaghan R, Hart LR, Li T, Ravisankar P, Brown JA, Amir M, Jin JC, Savage AR, Luo R, Rowdo FM, Martin ML, Silver RB, Guo CJ, Krumsiek J, Inohara N, Zeng MY.   +19 more
europepmc   +1 more source

Targeted Delivery of α‐ketoglutarate to Macrophages in Bone: A Novel Therapeutic Strategy for Improving Fracture Healing in Type 2 Diabetes

Advanced Science, EarlyView.
The study reveals that glutaminolysis in macrophages is inhibited under type 2 diabetes mellitus (T2DM) conditions, which impedes fracture healing by reducing bone morphogenetic protein 2 (BMP2) production through increased cytosine methylation on the promoter.
Jing Wang, Jiahao Cao, Siqi Zhang, Hongli Chen, Xuebing Yu, Xinli Wang, Tianji Wang, Wei Cao, Wengang Dong, Xinsen Lin, Jia Li, Wei Lei, Yafei Feng   +12 more
wiley   +1 more source

Establishment and validation of a predictive model of immune tolerance after pediatric liver transplantation: a multicenter cohort study. [PDF]

Int J Surg
Wang B, Zhou A, Wu Y, Pan Q, Wei X, Gao Y, Xiao W, Jin J, Zhou T, Luo Y, Zhan Z, Liu Y, Gao W, Liu Y, Xia Q.   +14 more
europepmc   +1 more source

Enhancer Extrachromosomal Circular DNA ANKRD28 Elicits Drug Resistance via POU2F2‐Mediated Transcriptional Network in Multiple Myeloma

Advanced Science, EarlyView.
Enhancer eccANKRD28‐manipulated MM cells have been demonstrated to facilitate drug resistance and promote MM progression by activating the key transcription factor, POU2F2. POU2F2 interacts with sequence‐specific eccANKRD28 as well as RUNX1 and RUNX2 motifs to form the protein complex, which activates the promoter of oncogenes (IRF4, JUNB, IKZF3, et al.
Binzhen Chen, Jia Liu, Yaoxin Zhang, Changming Shi, Di Zhu, Guoqiang Zhang, Fei Xiao, Lu Zhong, Minyue Zhang, Lai Guan Ng, Honghui Huang, Tingting Lu, Jian Hou   +12 more
wiley   +1 more source

SARS-CoV-2 envelope protein regulates innate immune tolerance. [PDF]

iScience
Geanes ES, McLennan R, Pierce SH, Menden HL, Paul O, Sampath V, Bradley T.   +6 more
europepmc   +1 more source

SSRP1/SLC3A2 Axis in Arginine Transport: A New Target for Overcoming Immune Evasion and Tumor Progression in Peripheral T‐Cell Lymphoma

Advanced Science, EarlyView.
Enhanced arginine uptake is a critical feature of metabolic reprogramming in PTCL, characterized by elevated expression of the arginine transporter SLC3A2. SLC3A2‐mediated arginine uptake facilitates PTCL proliferation and survival by enhancing OXPHOS metabolism and inducing immune evasion.
Yimin Ren, Lei Fan, Ling Wang, Yanping Liu, Jie Zhang, Boya Wang, Ruize Chen, Xiao Chen, Lingyu Zhuang, Yaping Zhang, Handong Sun, Jianyong Li, Wenyu Shi, Hui Jin   +13 more
wiley   +1 more source

Early life imprinting of intestinal immune tolerance and tissue homeostasis. [PDF]

Immunol Rev
Paucar Iza YA, Brown CC.
europepmc   +1 more source