Results 41 to 50 of about 2,852,359 (355)

Modular immune-homeostatic microparticles promote immune tolerance in mouse autoimmune models

Science Translational Medicine, 2021
Modular microparticles induce antigen-specific immune tolerance by inducing apoptosis and promoting Treg differentiation. Augmenting autoimmunity Current treatment options for many autoimmune conditions rely on systemic immune suppression, putting ...
Xin Chen, Xiaoshan Yang, Pingyun Yuan, Ronghua Jin, Lili Bao, X. Qiu, Siying Liu, Tao liu, J. Gooding, Wanjun Chen, Guozhen Liu, Yongkang Bai, Shiyu Liu, Yan Jin   +13 more
semanticscholar   +1 more source

Loss of Zbtb32 in NOD mice does not significantly alter T cell responses. [version 2; referees: 2 approved]

F1000Research, 2018
Background: We previously identified the transcriptional regulator Zbtb32 as a factor that can promote T cell tolerance in the Non-Obese Diabetic (NOD) mouse, a model of Type 1 diabetes.
William D. Coley, Yongge Zhao, Charles J. Benck, Yi Liu, Chie Hotta-Iwamura, M. Jubayer Rahman, Kristin V Tarbell   +6 more
doaj   +1 more source

Loss of Zbtb32 in NOD mice does not significantly alter T cell responses. [version 1; referees: 2 approved]

F1000Research, 2018
Background: We previously identified the transcriptional regulator Zbtb32 as a factor that can promote T cell tolerance in the Non-Obese Diabetic (NOD) mouse, a model of Type 1 diabetes.
William D. Coley, Yongge Zhao, Charles J. Benck, Yi Liu, Chie Hotta-Iwamura, M. Jubayer Rahman, Kristin V Tarbell   +6 more
doaj   +1 more source

Histopathology of the gut in rheumatic diseases [PDF]

, 2018
The gastrointestinal tract regulates the trafficking of macromolecules between the environment and the host through an epithelial barrier mechanism and is an important part of the immune system controlling the equilibrium between tolerance and immunity ...
Ciccia F., Ferrante A., Guggino G., Macaluso F., Rizzo A.   +4 more
core   +1 more source

Beta cell and immune cell interactions in autoimmune type 1 diabetes: How they meet and talk to each other

Molecular Metabolism, 2022
Background: The highly complex pathogenesis of Type 1 Diabetes is driven by several immune cell types with both effector and regulatory characteristics, which ultimately ends in the destruction of the insulin-producing beta cells.
Martin G. Scherm, Rebecca C. Wyatt, Isabelle Serr, David Anz, Sarah J. Richardson, Carolin Daniel   +5 more
doaj   +1 more source

Role of Regulatory T Cells in Regulating Fetal-Maternal Immune Tolerance in Healthy Pregnancies and Reproductive Diseases

Frontiers in Immunology, 2020
Regulatory T cells (Tregs) are a specialized subset of T lymphocytes that function as suppressive immune cells and inhibit various elements of immune response in vitro and in vivo.
N. Huang, H. Chi, J. Qiao
semanticscholar   +1 more source

Quantitative Proteomics Identifies TCF1 as a Negative Regulator of Foxp3 Expression in Conventional T Cells

iScience, 2020
Summary: Regulatory T cells are important regulators of the immune system and have versatile functions for the homeostasis and repair of tissues. They express the forkhead box transcription factor Foxp3 as a lineage-defining protein.
Michael Delacher, Melanie M. Barra, Yonatan Herzig, Katrin Eichelbaum, Mahmoud-Reza Rafiee, David M. Richards, Ulrike Träger, Ann-Cathrin Hofer, Alexander Kazakov, Kathrin L. Braband, Marina Gonzalez, Lukas Wöhrl, Kathrin Schambeck, Charles D. Imbusch, Jakub Abramson, Jeroen Krijgsveld, Markus Feuerer   +16 more
doaj   +1 more source

Intestinal macromolecular transport supporting adaptive immunity [PDF]

, 2019
The gastrointestinal tract performs opposing functions of nutrient absorption, barrier maintenance, and the delivery of luminal substances for the appropriate induction of tolerogenic or protective adaptive immunity.
Kulkarni, Devesha H, Newberry, Rodney D
core   +2 more sources

miRNA-Mediated Immune Regulation in Islet Autoimmunity and Type 1 Diabetes

Frontiers in Endocrinology, 2020
The important role of microRNAs as major modulators of various physiological processes, including immune regulation and homeostasis, has been increasingly recognized.
Martin G. Scherm, Martin G. Scherm, Carolin Daniel, Carolin Daniel, Carolin Daniel   +4 more
doaj   +1 more source

Antigen-Specific Treg Therapy in Type 1 Diabetes – Challenges and Opportunities

Frontiers in Immunology, 2021
Regulatory T cells (Tregs) are key mediators of peripheral self-tolerance and alterations in their frequencies, stability, and function have been linked to autoimmunity.
Isabelle Serr, Isabelle Serr, Felix Drost, Benjamin Schubert, Benjamin Schubert, Carolin Daniel, Carolin Daniel, Carolin Daniel   +7 more
doaj   +1 more source