Results 61 to 70 of about 288,299 (272)
Molecular Oncology, Volume 19, Issue 5, Page 1386-1403, May 2025.Adaptive ERK reactivation hinders FLT3 tyrosine kinase inhibitor (TKI) treatment in FLT3/ITD acute myeloid leukemia. Here, we report that FLT3 TKI treatment rapidly induces AXL expression and upregulation that is temporally associated with the adaptive ERK reactivation.
Tessa S. Seale +9 more
wiley +1 more source
Towards understanding the immune system [PDF]
arXiv, 2008 It is proposed that using both self-non-self and danger theories give a better understanding of how the immune system works. It is proposed that comparing immune system to police force is useful in this case since police responds both to danger or damage signals and to foreign or suspicious behavior even if no danger signals existed.
arxiv
Effect of In-vivo Heat Challenge on Physiological Parameters and Function of Peripheral Blood Mononuclear Cells in Immune Phenotyped Dairy Cattle [PDF]
arXiv, 2022 The frequency of heat waves are increasing due to climate change, which leads to an increase in the occurrence of heat stress in dairy cattle. Previous studies have shown that dairy cattle identified as high immune responders have a reduced incidence of disease and improved vaccine response compared to average and low responders.
arxiv
Molecular Oncology, EarlyView.Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé +7 more
wiley +1 more source
Molecular Metabolism, 2022 Background: The highly complex pathogenesis of Type 1 Diabetes is driven by several immune cell types with both effector and regulatory characteristics, which ultimately ends in the destruction of the insulin-producing beta cells.
Martin G. Scherm +5 more
doaj
Cooperative Automated Worm Response and Detection Immune Algorithm [PDF]
arXiv, 2010 The role of T-cells within the immune system is to confirm and assess anomalous situations and then either respond to or tolerate the source of the effect. To illustrate how these mechanisms can be harnessed to solve real-world problems, we present the blueprint of a T-cell inspired algorithm for computer security worm detection.
arxiv
Molecular Oncology, EarlyView.TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair +17 more
wiley +1 more source
Introducing Dendritic Cells as a Novel Immune-Inspired Algorithm for Anomoly Detection [PDF]
Proceedings of the 4th International Conference on Artificial
Immune Systems (ICARIS2005), Lecture Notes in Computer Science 3627, Banff,
Canada, 2005, 2010 Dendritic cells are antigen presenting cells that provide a vital link between the innate and adaptive immune system. Research into this family of cells has revealed that they perform the role of coordinating T-cell based immune responses, both reactive and for generating tolerance. We have derived an algorithm based on the functionality of these cells,
arxiv
Molecular Oncology, EarlyView.Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser +11 more
wiley +1 more source
iScience, 2020 Summary: Regulatory T cells are important regulators of the immune system and have versatile functions for the homeostasis and repair of tissues. They express the forkhead box transcription factor Foxp3 as a lineage-defining protein.
Michael Delacher +16 more
doaj