Results 41 to 50 of about 1,132 (124)

Denervation causes fiber atrophy and myosin heavy chain co-expression in senescent skeletal muscle.

PLoS ONE, 2012
Although denervation has long been implicated in aging muscle, the degree to which it is causes the fiber atrophy seen in aging muscle is unknown. To address this question, we quantified motoneuron soma counts in the lumbar spinal cord using choline ...
Sharon L Rowan, Karolina Rygiel, Fennigje M Purves-Smith, Nathan M Solbak, Douglas M Turnbull, Russell T Hepple   +5 more
doaj   +1 more source

Immunhistochemistry (Stadelmann Lab - single antibody, DAB-POX-Avidin-Biotin) v1

This protocol describes staining of any primary antibody using a biotin coupled secondary antibody using Avidin coupled peroxidase.
Jonas Franz, Katja Schulz, Christine Stadelmann   +2 more
openaire   +1 more source

Development of an optimized, non‐stem cell line for intranasal delivery of therapeutic cargo to the central nervous system

Molecular Oncology, Volume 18, Issue 3, Page 528-546, March 2024.
Hepatic stellate LX‐2 cells underwent several augmentations, such as in vivo tracking (mCherry labeling), increased migration capacity by selecting fast migrating cells from repeated cycles of in vitro migration (LX‐2 FR) and greater safety (LX‐2 FR/TK).
Ali El‐Ayoubi, Arsen Arakelyan, Moritz Klawitter, Luisa Merk, Siras Hakobyan, Irene Gonzalez‐Menendez, Leticia Quintanilla Fend, Per Sonne Holm, Wolfgang Mikulits, Matthias Schwab, Lusine Danielyan, Ulrike Naumann   +11 more
wiley   +1 more source

Renal phenotype of Et-1 transgenic mice is modulated by androgens

European Journal of Medical Research, 2009
Introduction Activation of the endothelin (ET) system promotes inflammation and fibrosis in various tissues including the kidney. Male ET-1 transgenic mice are characterized by chronic kidney inflammation and renal scarring.
Kalk P, Thöne-Reineke C, Schwarz A, Godes M, Bauer C, Pfab T, Hocher B   +6 more
doaj   +1 more source

Decidual-secreted factors alter invasive trophoblast membrane and secreted proteins implying a role for decidual cell regulation of placentation.

PLoS ONE, 2012
Inadequate or inappropriate implantation and placentation during the establishment of human pregnancy is thought to lead to first trimester miscarriage, placental insufficiency and other obstetric complications.
Ellen Melaleuca Menkhorst, Natalie Lane, Amy Louise Winship, Priscilla Li, Joanne Yap, Katie Meehan, Adam Rainczuk, Andrew Stephens, Evdokia Dimitriadis, Evdokia Dimitriadis   +9 more
doaj   +1 more source

Multimodal Approaches for Regenerative Stroke Therapies: Combination of Granulocyte Colony-Stimulating Factor with Bone Marrow Mesenchymal Stem Cells is Not Superior to G-CSF Alone

Frontiers in Aging Neuroscience, 2014
Attractive therapeutic strategies to enhance post-stroke recovery of aged brains include methods of cellular therapy that can enhance the endogenous restorative mechanisms of the injured brain.
Adrian Tudor Balseanu, Ana-Maria Buga, Ana-Maria Buga, Bogdan Catalin, Daniel-Christoph Wagner, Johannes Boltze, Johannes Boltze, Johannes Boltze, Ana-Maria Zagrean, Klaus Reymann, Wolf Schaebitz, Aurel Popa-Wagner, Aurel Popa-Wagner   +12 more
doaj   +1 more source

Validation of cytoplasmic-to-nuclear ratio of survivin as an indicator of improved prognosis in breast cancer

BMC Cancer, 2010
Background Conflicting data exist regarding the prognostic and predictive impact of survivin (BIRC5) in breast cancer. We previously reported survivin cytoplasmic-to-nuclear ratio (CNR) as an independent prognostic indicator in breast cancer.
Duffy Michael J, Landberg Goran, O'Brien Sallyann L, O'Connor Darran P, Jirstrom Karin, Rexhepaj Elton, Brennan Donal J, Gallagher William M   +7 more
doaj   +1 more source

Promoter methylation-associated loss of ID4 expression is a marker of tumour recurrence in human breast cancer

BMC Cancer, 2008
Background Inhibitor of DNA binding/Inhibitor of differentiation 4 (ID4) is a critical factor for cell proliferation and differentiation in normal vertebrate development. ID4 has regulative functions for differentiation and growth of the developing brain.
Hartmann Arndt, Horn Felicitas, Galm Oliver, Niederacher Dieter, Veeck Jürgen, Noetzel Erik, Knüchel Ruth, Dahl Edgar   +7 more
doaj   +1 more source

Proceedings 30th Symposium ESVN‐ECVN

, 2020
Journal of Veterinary Internal Medicine, Volume 34, Issue 1, Page 446-487, January/February 2020.
wiley   +1 more source

Early histopathological changes of secondary degeneration in the spinal cord after total MCA territory stroke. [PDF]

Sci Rep, 2023
Kollai S, Bereczki D, Glasz T, Hortobágyi T, Kovács T.   +4 more
europepmc   +1 more source