Results 41 to 50 of about 1,365 (166)

A Human Immuno‐Lung Organoid Model to Study Macrophage‐Mediated Lung Cell Senescence Upon SARS‐CoV‐2 Infection

open access: yesAdvanced Science, Volume 12, Issue 36, September 25, 2025.
Immuno‐lung organoids are developed and used spatial transcriptomics to uncover how proinflammatory macrophages drive lung cell senescence via the THBS1–(ITGA3+ITGB1) axis in COVID‐19. To ensure broad accessibility, LungSpatialDB is created, an AI‐powered data portal, enabling intuitive exploration of spatial data and biological insights through ...
Yuling Han   +24 more
wiley   +1 more source

Evaluation of the correlation of vasculogenic mimicry, ALDH1, KAI1 and microvessel density in the prediction of metastasis and prognosis in colorectal carcinoma

open access: yesBMC Surgery, 2017
Background Metastasis and recurrence are the most common reasons for treatment failure of colorectal carcinoma (CRC). Vasculogenic mimicry (VM, blood supply formation often seen in highly aggressive tumors), Aldehyde dehydrogenase 1 (ALDH1, a biomarker ...
Bo Zhu   +6 more
doaj   +1 more source

The Effect of Time on Apoptosis Changes Following Ischemia-Reperfusion in Isolated Heart of Rats

open access: yesAsian Pacific Journal of Cancer Biology, 2017
Background and objective: To study the time-dependent effects of ischemia – reperfusion on myocardium cells. Methodology: Male SD rats (270-330gr) were randomly grouped in four groups of 10 in an experimental study.
Yusef Dostar   +3 more
doaj   +1 more source

Effect of inoculum density on human‐induced pluripotent stem cell expansion in 3D bioreactors

open access: yesCell Proliferation, Volume 52, Issue 4, July 2019., 2019
Abstract Objective For optimized expansion of human‐induced pluripotent stem cells (hiPSCs) with regards to clinical applications, we investigated the influence of the inoculum density on the expansion procedure in 3D hollow‐fibre bioreactors. Materials and Methods Analytical‐scale bioreactors with a cell compartment volume of 3 mL or a large‐scale ...
Selina Greuel   +8 more
wiley   +1 more source

Prevalence of Syndecan‐1 (CD138) Expression in Different Kinds of Human Tumors and Normal Tissues

open access: yesDisease Markers, Volume 2019, Issue 1, 2019., 2019
Syndecan‐1 (CD138) is a transmembrane proteoglycan known to be expressed in various normal and malignant tissues. It is of interest because of a possible prognostic role of differential expression in tumors and its role as a target for indatuximab, a monoclonal antibody coupled with a cytotoxic agent.
Simon Kind   +23 more
wiley   +1 more source

The effect of time on apoptosis changes following ischemia-reperfusion in isolated heart of rats

open access: yesAsian Pacific Journal of Cancer Biology, 2018
Background and objective: To study the time-dependent effects of ischemia – reperfusion on myocardium cells. Methodology: Male SD rats (270-330gr) were randomly grouped in four groups of 10 in an experimental study.
Mehrdad Hashemi   +2 more
doaj   +1 more source

Updated consumer risk assessment of fluoride in food and drinking water including the contribution from other sources of oral exposure

open access: yesEFSA Journal, Volume 23, Issue 7, July 2025.
Abstract This updated risk assessment evaluated evidence on potential adverse health effects of fluoride related to all sources of oral exposure as mandated by the European Commission. Fluoride benefit assessment was not included. Effects on the central nervous system, thyroid and bone were prioritised.
EFSA Scientific Committee   +34 more
wiley   +1 more source

TUNEL staining of zebrafish retina, 3 days after exposure to MNU 150 mg/l.

open access: yes, 2013
A. TUNEL-positive cells (red) are localized in the outer nuclear layer. Strong autofluorescence (green) of a cone outer segment allows identification of the corresponding nearby cone nucleus.
Jasmin Balmer (444165)   +6 more
core   +1 more source

The value of ultrasound-guided biopsy of fluorodeoxy-glucose positron emission tomography (FDG-PET)-positive supraclavicular lymph nodes in patients with suspected lung cancer

open access: yesBMC Medical Imaging, 2017
Background Accurate lymph node staging is essential for adequate prognostication and therapy planning in patients with non-small cell lung cancer (NSCLC).
Lennart Werner   +7 more
doaj   +1 more source

Data Supplement from Phase I Expansion and Pharmacodynamic Study of the Oral MEK Inhibitor RO4987655 (CH4987655) in Selected Patients with Advanced Cancer with RAS–RAF Mutations

open access: yes, 2014
Supplementary Figure 2. Case study: 64-year old female with BRAF V600-mutant melanoma (A)Immunhistochemistry for Ki67 expression showing a reduction between baseline and cycle1/day15 in lymph node biopsies (B)Immunhistochemistry for pERK expression ...
Veronique Dieras (5654347)   +18 more
core   +1 more source

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