Results 171 to 180 of about 171,680 (341)

Prenatal alcohol exposure increases the aggressiveness of estrogen‐induced pituitary tumors in male rats

open access: yesAlcohol, Clinical and Experimental Research, EarlyView.
Prenatal alcohol exposure (PAE) enhances the development of aggressive pituitary tumors (PitNETs) in female rats. In this study, we found that PAE also promotes the development of PitNETs in male rats. Like in females, PAE treatment enhances the expression of stem cell and tumor aggressiveness genes and increases tumor cell proliferation rate ...
Shaista Chaudhary, Dipak K. Sarkar
wiley   +1 more source

The use of deidentified organ donor testes for research

open access: yesAndrology, EarlyView.
Abstract Our knowledge of testis development and function mainly comes from research using mammalian model organisms, primarily the mouse. However, there are integral differences between men and other mammalian species regarding cellular composition and expression profiles during fetal and post‐natal testis development and in the mature testis ...
Marina V. Pryzhkova   +4 more
wiley   +1 more source

The Oxytocin Receptor in Spermatozoa May Originate From Both Spermatogenesis and Epididymal Maturation, and Regulates Capacitation

open access: yesAndrology, EarlyView.
Abstract Background The oxytocin receptor (OR) is a G‐protein‐coupled receptor recently identified in human spermatozoa, whose origin and role in sperm physiology remain unknown. Objectives In this study, using the pig as a model, we examine the presence of the OR in ejaculated spermatozoa through immunofluorescence and immunoblotting, and investigate ...
Jesús Martínez‐Hernández   +9 more
wiley   +1 more source

A model for de novo pigmentation of amelanotic retinal pigment epithelial cells

open access: yesActa Ophthalmologica, EarlyView.
Abstract Purpose Retinal Pigment Epithelial (RPE) cells perform critical functions in the visual cycle. Their melanin pigmentation, which is organized into specialized compartments – melanosomes, is highly critical for proper vision. A chemical method to induce pigmentation in a non‐pigmented model of ARPE‐19 cells was applied using L‐DOPA as a ...
Santosh Gupta   +10 more
wiley   +1 more source

Neural Cells adhesion Molecule NCAM in neural and endocrine cells [PDF]

open access: yes, 1991
Gratzl, Manfred   +3 more
core   +1 more source

Addition of hydroxyurea (hydroxycarbamide) enhances the efficacy of fludarabine/cytarabine‐based salvage regimens against acute myeloid leukaemia

open access: yesBritish Journal of Haematology, EarlyView.
Left: Cells with active SAMHD1 can metabolize cytarabine (ara‐C) and fludarabine (F‐ara‐A) to their inactive precursors, limiting their cytotoxic effects. Right: Addition of hydroxyurea (hydroxycarbamide; HU) inhibits SAMHD1, leading to an increase in the active metabolites of ara‐C and F‐ara‐A and a subsequent increase in the cytotoxicity of these ...
Ingrid Lilienthal   +23 more
wiley   +1 more source

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