Results 191 to 200 of about 171,680 (341)

Anticancer Effect of the Triphenylphosphonium‐Conjugated Quinolone Antibiotics Targeting Mitochondrial DNA Replication

open access: yesCancer Science, EarlyView.
Mitochondrial DNA replication‐targeting quinolone derivatives, termed MitoQNs, are synthesized. They exhibit reduced antibacterial activity and enhanced anticancer efficacy and thus could be candidate drugs for cancer therapy. ABSTRACT Antibacterial quinolones are widely used to treat bacterial infections in humans.
Yuming Qiao   +6 more
wiley   +1 more source

Investigating Microinvasive Intra‐Ocular Biopsy

open access: yesClinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background Current minimally invasive methods of intraocular biopsy are confined to small gauge (G) needles and subretinal cannulae that can be prone to wound leakage at the biopsy site. We investigate the role of microneedles with internal diameters as small as 49G for intraocular biopsy in the posterior and anterior segments.
Jared Ching   +3 more
wiley   +1 more source

Alterations of bone proteins in medication‐related osteonecrosis of the jaw

open access: yesEuropean Journal of Oral Sciences, Volume 133, Issue 2, April 2025.
Abstract Changes in the protein expression pattern of osteoblastic lineage cells from the alveolar bone (OLAB) during medication‐related osteonecrosis of the jaw (MRONJ) have rarely been investigated. This lack of information is partly because of the limited availability of healthy samples and the lack of human alveolar bone cell lines for research ...
Andrea Schubert   +6 more
wiley   +1 more source

Rescue of ciliogenesis and hyperglutamylation mutant phenotype in AGBL5<sup>-/-</sup> cell model of retinitis pigmentosa. [PDF]

open access: yesBMC Mol Cell Biol
Villa-Vasquez SS   +5 more
europepmc   +1 more source

Diagnostic relevance of peripheral blood immunocytochemistry in hairy cell leukaemia. [PDF]

open access: bronze, 1995
Iole Cordone   +9 more
openalex   +1 more source

The transcriptomic signature of DEPDC5 KO induced mTOR hyperactivation in human neurons and its response to rapamycin treatment

open access: yesEpilepsia, EarlyView.
Abstract Objective Mutations of the DEP Domain Containing 5 gene (DEPDC5), a mechanistic Target of Rapamycin (mTOR) inhibitor involved in amino acid sensing, are associated with neurological diseases such as epilepsy and/or autism spectrum disorder (ASD). Loss of DEPDC5 impacts early neuronal development via mTOR hyperactivity.
Mattson S. O. Jones   +14 more
wiley   +1 more source

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