Results 91 to 100 of about 408 (149)

Single-Chain Variable Fragment Fusion Proteins for Targeted Delivery and Therapy

Pharmaceuticals
A single-chain variable fragment (scFv) is an engineered antibody derivative that retains antigen-binding specificity while having a much smaller size than an antibody, improved tissue penetration, and enhanced versatility for genetic manipulation.
Luona Yang, Yuan Yin, Xinli Liu, Bin Guo
doaj   +1 more source

Comparable immunogenicity of new modality biotherapeutics delivered subcutaneously or intravenously in non-human primates

Journal of Immunotoxicology
Unwanted immunogenicity of therapeutic proteins arises through the combination of many factors, with the route of administration considered a significant contributor.
Victoria Koch, Martin Lechmann, Katharine Bray-French, Matthias Füth, Elisabeth Husar, Niels Janssen, Anneliese Schneider, Kay Stubenrauch, Timothy Hickling, Sven Kronenberg   +9 more
doaj   +1 more source

Issue Information

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 12, Page 1893-1896, December 2025.
wiley   +1 more source

αTIGIT-IL2 achieves tumor regression by promoting tumor-infiltrating regulatory T cell fragility in mouse models

Nature Communications
Administration of IL-2 may promote the suppressive function and proliferation of Treg cells that cause immune tolerance in patients with cancer, which causes low-dose IL-2 to fail in achieving an optimal anti-tumor effect.
Tianci Wang, Yupu Xu, Zhengfeng Zhang, Yaqi Wu, Long Chen, Xiaodong Zheng, Hui Peng, Qiang Zou, Rui Sun, Hongdi Ma, Haoyu Sun, Zhigang Tian, Xiaohu Zheng   +12 more
doaj   +1 more source

Engineering and Characterization of Tumor Antigen Affinity-Varying IgG-Fused Interleukin-12 Immunocytokines

, 2022
학위논문(석사)--아주대학교 일반대학원 :분자과학기술학과,2022. 8최근 많은 연구들에서 IL-12의 종양에 대한 향상된 노출 및 종양으로의 유도를 위해 IL-12의 표적 전달이 시도되어왔다. 그러나, 부족한 종양 침투 및 분포는 종양 미세 환경 내에서 항종양 면역 세포의 효과기 기능을 자극하기 어렵게 만든다.
유소정
core  

An anti-CD30 immunocytokine with combined IL-2 and IL-12 domains enhances anti-tumour immunity [PDF]

, 2010
Classical Hodgkin’s lymphoma is one of the most curable cancers today. However, non-responders, tumour relapses and long-term toxicities of the treatment make it necessary to look for alternative drugs.
Zuther, Martin
core   +1 more source

Preparation of truncated forms of recombinant immunocytokines with interleukin-2

Interleukin-2 (IL-2) belongs to the group of cytokines, small molecules involved in the modulation of the immune response. IL-2 plays a dual role in immune processes: depending on the concentration present in blood, it either ensures self-tolerance ...
Bragina, Nadezda
core   +1 more source

Click-to-release for immune cell activation [PDF]

This work describes the use of click-to-release chemistry to get spatiotemporal control over immunocytokine activity. Until now, immunocytokines (cytokines coupled to a tumor-targeting-moiety) remained active throughout the body, being able to bind their
Barendrecht, A.
core  

Engineered cytokine/antibody fusion proteins improve IL-2 delivery to pro-inflammatory cells and promote antitumor activity

JCI Insight
Progress in cytokine engineering is driving therapeutic translation by overcoming these proteins’ limitations as drugs. The IL-2 cytokine is a promising immune stimulant for cancer treatment but is limited by its concurrent activation of both pro ...
Elissa K. Leonard, Jakub Tomala, Joseph R. Gould, Michael I. Leff, Jian-Xin Lin, Peng Li, Mitchell J. Porter, Eric R. Johansen, Ladaisha Thompson, Shanelle D. Cao, Shenda Hou, Tereza Henclova, Maros Huliciak, Paul R. Sargunas, Charina S. Fabilane, Ondřej Vaněk, Marek Kovar, Bohdan Schneider, Giorgio Raimondi, Warren J. Leonard, Jamie B. Spangler   +20 more
doaj   +1 more source

Targeting Strategies in Cancer Immunotherapy: Comparative Evaluation of Stromal and Cellular Antigens for Bispecific Antibodies and Immunocytokines

Cancer remains one of the leading causes of mortality worldwide, resulting in millions of deaths annually, despite significant advances in detection and treatment. Conventional therapies such as surgery, radiation, and chemotherapy have improved survival
Pfister, Stefanie Kathrin
core