Results 101 to 110 of about 408 (149)

PD-1–targeted IL-15 mutein activates CD8+ and CD4+ T cells in infection and cancer

JCI Insight
Immune checkpoint inhibitors have transformed cancer therapy, yet many patients fail to achieve durable responses due to insufficient T cell reinvigoration.
Isaraphorn Pratumchai, Marie Bernardo, Julien Tessier, Jaroslav Zak, Kristi L. Marquardt, Joon Sang Lee, Maheeka Bimal, AHyun Choi, Anthony M. Byers, Mikielia G. Devonish, Roberto Carrio, Dan Lu, Stella Martomo, Jeegar Patel, Yu-an Zhang, Ingeborg M. Langohr, Virna Cortez-Retamozo, Dinesh S. Bangari, Angela Hadjipanayis, Xiangming Li, Valeria R. Fantin, Donald R. Shaffer, John R. Teijaro   +22 more
doaj   +1 more source

Immunocytokine NHS-IL12 [PDF]

, 2020
openaire   +1 more source

Immunocytokine NHS-IL2-LT [PDF]

, 2020
openaire   +1 more source

Abstract 2863: Immunocytokines with target cell-restricted IL-15 activity for treatment of B cell malignancies

, 2022
Martina S. Lutz, Ilona Hagelstein, Melanie Märklin, Gundram Jung, Boris Klimovich, Carsten Greve, Stefanie Müller, Helmut R. Salih, Latifa Zekri, Bastian Schmied   +9 more
core   +1 more source

DI-Leu16-IL2 Immunocytokine [PDF]

, 2020
openaire   +1 more source

Novel immunocytokines for cancer therapy

, 2012
openaire   +2 more sources

Immunocytokines Turn Up the Heat in Glioblastoma

Nature Reviews Drug Discovery, 2020
2558 Background: There is an urgent need for novel treatment options for patients with glioblastoma, the most frequent malignant primary brain tumor. In contrast to other types of cancer, immunotherapeutic approaches have so far not been successful against glioblastoma. Converting the glioma microenvironment from a "cold" and immunosuppressive status
M Teresa Villanueva
exaly   +12 more sources

Immunocytokines for Cancer Treatment: Past, Present and Future [PDF]

Current Opinion in Immunology, 2016
Immunocytokines are antibody-cytokine fusion proteins, with the potential to preferentially localize on tumor lesions and to activate anticancer immunity at the site of disease. Various tumor targets (e.g., cell membrane antigens and extracellular matrix components) and antibody formats (e.g., intact IgG and antibody fragments) have been considered for
Dario Neri, Paul M Sondel
exaly   +6 more sources

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Immunocytokines for Cancer Therapy

Onco Therapeutics, 2014
Dario Neri, Philipp Probst
exaly   +2 more sources

Immunocytokines

Melanoma Research, 1997
Targeted interleukin-2 (IL-2) therapy with immunocytokines (i.e. antibody-cytokine fusion proteins) is effective in eradicating established hepatic and pulmonary metastases of melanoma in animal model systems. The effector mechanisms responsible for this antitumor effect in syngeneic, immunocompetent mice involves mainly CD8+ T cells.
R A, Reisfeld, J C, Becker, S D, Gillies
openaire   +2 more sources