Results 21 to 30 of about 408 (149)
Immunocytokines: a review of molecules in clinical development for cancer therapy
Clinical Pharmacology: Advances and Applications, 2013 Thomas List, Dario NeriDepartment of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH Zürich), Zurich, SwitzerlandAbstract: The concept of therapeutically enhancing the immune system’s responsiveness to tumors is ...
List T, Neri D
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, 2021 The use of immunomodulatory agents for the treatment of cancer is gaining a growing biopharmaceutical interest. Antibody-cytokine fusion proteins, namely immunocytokines, represent a promising solution for the regulation of the immune system at the site ...
Scietti, Luigi +23 more
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Emerging new therapeutic antibody derivatives for cancer treatment
Signal Transduction and Targeted Therapy, 2022 Monoclonal antibodies constitute a promising class of targeted anticancer agents that enhance natural immune system functions to suppress cancer cell activity and eliminate cancer cells.
Shijie Jin +7 more
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Бюллетень сибирской медицины, 2023 The aim of the study was to identify the features of the cellular composition and cytokine profile of bronchoalveolar lavage fluid in rats in a model of diet-induced metabolic syndrome.Materials and methods. In an experiment on animals (rats), a model of
O. V. Voronkova +8 more
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Immunotoxines et immunocytokines [PDF]
médecine/sciences, 2019 Les cytokines et les toxines biologiques représentent deux classes de biomolécules qui ont longtemps été explorées pour leur potentiel thérapeutique. Des effets secondaires considérables et des mauvaises propriétés pharmacocinétiques sont fréquemment observés chez chacune d’elles, ce qui limite leur application. L’ingénierie des protéines recombinantes
Alicia Contet +3 more
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Soluble Expression of a Neo2/15-Conjugated Single Chain Fv against PD-L1 in Escherichia coli
Current Issues in Molecular Biology, 2022 Immunocytokines, antibody-cytokine fusion proteins, have the potential to improve the therapeutic index of cytokines by delivering the cytokine to the site of localized tumor cells using antibodies.
Sun-Hee Kim, Hee-Jin Jeong
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NHS-IL12, a Tumor-Targeting Immunocytokine
ImmunoTargets and Therapy, 2021 NHS-IL12 is a novel immunocytokine designed for delivery of IL-12 to the tumor microenvironment (TME). NHS-IL12 consists of two molecules of IL-12 fused to a human IgG1 (NHS76) recognizing DNA/histone complexes, which are often exposed in the necrotic portions of tumors.
John W Greiner +2 more
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Molecular Engineering of Therapeutic Cytokines
Antibodies, 2013 Over the past three decades, a large body of work has been directed at the development of therapeutic cytokines. Despite their central role in immune modulation, only a handful of cytokine therapeutics has achieved regulatory approval.
Daniel Christ +2 more
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Frontiers in Immunology, 2016 The monospecific and bivalent characteristics of naturally occurring immunoglobulin G (IgG) antibodies depend on homodimerization of the fragment crystallizable (Fc) regions of two identical heavy chains (HCs) and the subsequent assembly of two identical
Ji-Hee Ha, Jung-Eun Kim, Yong-Sung Kim
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Cells, 2023 Neutrophils are crucial innate immune cells and comprise 50–70% of the white blood cell population under homeostatic conditions. Upon infection and in cancer, blood neutrophil numbers significantly increase because of the secretion of various chemo- and ...
Maria Tsioumpekou +3 more
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