Results 101 to 110 of about 619,127 (304)
Restriction of HIV-1 replication in monocytes is abolished by Vpx of SIVsmmPBj [PDF]
, 2009 Background: Human primary monocytes are refractory to infection with the human immunodeficiency virus 1 (HIV-1) or transduction with HIV-1-derived vectors.
Kaiser, Julia +23 more
core +2 more sources
Advanced Science, EarlyView.FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni +17 more
wiley +1 more source
Frontiers in Immunology, 2019 Non-canonical NF-κB-pathway signaling is integral in immunoregulation. Heterozygous mutations in NFKB2 have recently been established as a molecular cause of common variable immunodeficiency (CVID) and DAVID-syndrome, a rare condition combining ...
Christian Klemann +32 more
doaj +1 more source
Toward Personalized Theranostics: A Modular PET Platform for Antibody‐Based Imaging and Therapy
Advanced Science, EarlyView.This modular, site‐specific antibody platform enables customizable conjugates for PET imaging and therapy. Interchangeable payloads – including radiometals, cytotoxics, and fluorophores – support adaptable, multimodal applications with limited off‐target effects. In vivo, the DFO/DOTAGA bischelate immunoconjugate provided clear tumor delineation in PET/
Delphine Vivier +16 more
wiley +1 more source
Informasi Dasar Infeksi Human Immunodeficiency Virus (HIV) Dan Acquired Immunodeficiency Syndrome (AIDS) [PDF]
, 2018 Human immunodeficiency virus yang selanjutnya disingkat HIV adalah virus yang menyebabkan Acquired Immunodeficiency Syndrome (AIDS). Infeksi Human immunodeficiency virus (HIV) dan Acquired Immunodeficiency Syndrome (AIDS) merupakan suatu spektrum dari ...
Afif Nurul Hidayati, NIDN8855610016 +1 more
core +1 more source
Blood Advances: Primary hemophagocytic lymphohistiocytosis (HLH) is mainly caused by biallelic variants in genes disrupting cytotoxic natural killer (NK) cell and T-cell function (PRF1, UNC13D, STX11, STXBP2, RAB27A, and LYST).
Oleg Borisov +8 more
doaj +1 more source
Repurposing a Small Molecule Plant Hormone as a Tunable ON‐Switch for CAR‐T Cell Immunotherapy
Advanced Science, EarlyView.By engineering a receptor system integrating the plant auxin receptor AFB1 with its co‐receptor IAA7, we enable ligand‐dependent interactions triggered by the plant hormone auxins. This design allows rapid, reversible, and dose‐dependent T cell activation, resulting in potent cytotoxicity against B‐cell lymphoma in vitro and in vivo.
Hongxiang Zeng +16 more
wiley +1 more source
Guillain–Barré syndrome (GBS) after severe/critical COVID-19 or COVID-19 vaccination
European Journal of Medical ResearchBackground The global COVID-19 pandemic was initiated by the appearance of the novel coronavirus SARS-CoV-2 in 2019, presenting a spectrum of clinical manifestations from asymptomatic cases to severe pneumonia and multi-organ dysfunction, with some cases
Samira Bahrami +7 more
doaj +1 more source
PGM3 insufficiency: a glycosylation disorder causing a notable T cell defect
Frontiers in ImmunologyBackgroundHypomorphic mutations in the phosphoacetylglucosamine mutase 3 (PGM3) gene cause a glycosylation disorder that leads to immunodeficiency. It is often associated with recurrent infections and atopy.
Linlin Yang +19 more
doaj +1 more source
, 2023 At the request of the National Screening Advisory Committee (NSAC), the Health Information and Quality Authority (HIQA) agreed to undertake a health technology assessment (HTA) of the addition of severe combined immunodeficiency (SCID) to the National ...
Health Information and Quality Authority (HIQA)
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