Results 61 to 70 of about 21,232 (243)

Genetic signatures of AKT1 variants associated with worse COVID-19 outcomes – a multicentric observational study

open access: yesFrontiers in Immunology
IntroductionThe COVID-19, triggered by the SARS-CoV-2 virus, has varied clinical manifestations, ranging from mild cases to severe forms such as fatal pneumonia and acute respiratory distress syndrome (ARDS).
Ingrid Marins de Almeida   +25 more
doaj   +1 more source

Understanding Monoclonal B Cell Lymphocytosis: An Interplay of Genetic and Microenvironmental Factors

open access: yesFrontiers in Oncology, 2021
The term monoclonal B-cell lymphocytosis (MBL) describes the presence of a clonal B cell population with a count of less than 5 × 109/L and no symptoms or signs of disease.
Chrysi Galigalidou   +10 more
doaj   +1 more source

To Treat or Not to Treat: Navigating Early‐Stage CLL in the Era of Targeted Therapy

open access: yesEuropean Journal of Haematology, EarlyView.
ABSTRACT Chronic lymphocytic leukemia (CLL) is most frequently diagnosed at early, asymptomatic stages (Rai 0/Binet A), in which a watch‐and‐wait strategy remains the standard of care, based on historical trials demonstrating no overall survival benefit from early treatment.
Enrica Antonia Martino   +16 more
wiley   +1 more source

IMGT, the international ImMunoGeneTics database

open access: yes, 1997
IMGT, the international ImMunoGeneTics database, is an integrated database specializing in immunoglobulins, T-cell receptors (TcR) and major histocompatibility complex (MHC) of all vertebrate species, initiated and co-ordinated by Marie-Paule ...
Lefranc, M. P.   +31 more
core   +1 more source

Functional immune profiling reveals CD4+ T cell dysregulation in coeliac disease

open access: yesImmunology &Cell Biology, EarlyView.
The T cell momentum assay quantifies division, survival and activation decay to reveal intrinsic CD4+ programming defects marked by prolonged activation and impaired feedback control in coeliac disease. This scalable platform provides a functional screen for early T cell dysregulation across autoimmune and immune‐mediated diseases.
Anthony J Farchione   +13 more
wiley   +1 more source

Genomic and proteomic insights into hidradenitis suppurativa

open access: yesJournal of the European Academy of Dermatology and Venereology, EarlyView.
A dual pathogenic model of HS involving both epithelial dysfunction and systemic inflammation is supported. The HLA‐DRA association hints at autoimmune overlap, but the proteomic signature which is dominated by innate immune mediators favours an autoinflammatory classification, which may guide future therapeutic strategies and patient stratification ...
Maria Argyropoulou   +8 more
wiley   +1 more source

IMGT, the international ImMunoGeneTics information system®: a standardized approach for immunogenetics and immunoinformatics

open access: yes, 2005
IMGT, the international ImMunoGeneTics information system http://imgt.cines.fr, was created in 1989 by the Laboratoire d'ImmunoGénétique Moléculaire (LIGM) (Université Montpellier II and CNRS) at Montpellier, France.
Marie-Paule Lefranc   +1 more
core   +1 more source

Immunogenomics: Molecular hide and seek

open access: yesHuman Genomics, 2006
Similar to other classical science disciplines, immunology has been embracing novel technologies and approaches giving rise to specialised sub-disciplines such as immunogenetics and, more recently, immunogenomics, which, in many ways, is the genome-wide ...
Miretti Marcos M, Beck Stephan
doaj   +1 more source

Genes, fish and fisheries: translating science into policy

open access: yesJournal of Fish Biology, EarlyView.
Abstract The 2024 Annual Symposium of the Fisheries Society of the British Isles reviewed the burgeoning impact of ‘omics’ technologies on fish ecology, management and forecasting. As with life sciences more generally, major advances in speed, cost‐effectiveness and breadth of applications in ‘omics’ has had profound societal and environmental impacts.
Gary R. Carvalho
wiley   +1 more source

Molecular characterization of MHC class II in the Australian invasive cane toad reveals multiple splice variants

open access: yes, 2016
The cane toad has gained notoriety for its invasion across the Australian landscape, with significant impacts on the native Australian fauna. The invasion has accelerated over time, with invading cane toads adapted for highly dispersive traits.
Sveriges lantbruksuniversitet.   +1 more
core   +1 more source

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