Results 41 to 50 of about 17,783 (180)

Human leukocyte antigen allele linkage disequilibrium and haplotype structure in volunteer bone marrow donors of Paraná State

Revista Brasileira de Hematologia e Hemoterapia
Background Bone marrow transplantation has been used in the treatment of various diseases, especially hematologic diseases. The success of this treatment, among other factors, requires human leukocyte antigens (HLA) compatibility between patient and ...
Paulo Rincoski Costantino, Suelen Camargo Zeck, Waldir Antonio da Silva, Maria da Graça Bicalho   +3 more
doaj   +1 more source

Understanding Monoclonal B Cell Lymphocytosis: An Interplay of Genetic and Microenvironmental Factors

Frontiers in Oncology, 2021
The term monoclonal B-cell lymphocytosis (MBL) describes the presence of a clonal B cell population with a count of less than 5 × 109/L and no symptoms or signs of disease.
Chrysi Galigalidou, Chrysi Galigalidou, Laura Zaragoza-Infante, Laura Zaragoza-Infante, Anastasia Iatrou, Anastasia Chatzidimitriou, Anastasia Chatzidimitriou, Kostas Stamatopoulos, Kostas Stamatopoulos, Andreas Agathangelidis, Andreas Agathangelidis   +10 more
doaj   +1 more source

Long‐Term Follow‐Up Incidence of Type 1 Diabetes and Associated Autoimmune Diseases in First‐Degree Relatives

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background First‐degree relatives (FDRs) of individuals with type 1 diabetes (T1D) carry a significantly elevated risk of developing autoimmune diseases, including celiac disease (CD) and autoimmune thyroid disease (AITD). The DiaUnion 1.0 study aimed to characterize one‐time autoantibodies, genetic risk profiles and long‐term progression to ...
Julie H. Christensen, Gitte Lindved Petersen, Simranjeet Kaur, Alexander Lind, Samia Hamdan, Maria Naredi Scherman, Jesper Johannesen, Daniel Agardh, Julie C. Antvorskov, Flemming Pociot   +9 more
wiley   +1 more source

To Treat or Not to Treat: Navigating Early‐Stage CLL in the Era of Targeted Therapy

European Journal of Haematology, EarlyView.
ABSTRACT Chronic lymphocytic leukemia (CLL) is most frequently diagnosed at early, asymptomatic stages (Rai 0/Binet A), in which a watch‐and‐wait strategy remains the standard of care, based on historical trials demonstrating no overall survival benefit from early treatment.
Enrica Antonia Martino, Santino Caserta, Ernesto Vigna, Giovanna Cutrona, Antonella Bruzzese, Francesco Mendicino, Maria Eugenia Alvaro, Caterina Labanca, Eugenio Lucia, Virginia Olivito, Nicola Amodio, Franco Fais, Antonino Neri, Manlio Ferrarini, Valter Gattei, Fortunato Morabito, Massimo Gentile   +16 more
wiley   +1 more source

Histocompatibility and Immunogenetics in Cord Blood Transplantation

Biological Research, 2010
This review of the immunogenetics of cord blood transplantation attempts to highlight the connections between classical studies and conclusions of the tissue transplantation field as a scholarly endeavor, exemplified by the work of Professor Hoecker ...
Pablo Rubinstein, Christopher Hillyer
doaj  

Genetic signatures of AKT1 variants associated with worse COVID-19 outcomes – a multicentric observational study

Frontiers in Immunology
IntroductionThe COVID-19, triggered by the SARS-CoV-2 virus, has varied clinical manifestations, ranging from mild cases to severe forms such as fatal pneumonia and acute respiratory distress syndrome (ARDS).
Ingrid Marins de Almeida, Bruna Ramos Tosta, Laiane da Cruz Pena, Hatilla dos Santos Silva, Fabiane S. Reis-Goes, Nívia N. Silva, João Victor Andrade Cruz, Mailane dos Anjos Silva, Jéssica Francisco de Araújo, Juliana Lopes Rodrigues, Gabriella Oliveira, Ricardo Gassmann Figueiredo, Sara Nunes Vaz, Iris Montaño-Castellón, Daniele Santana, Alex Torres, Fabyan Esberard de Lima Beltrão, Valdirene Leão Carneiro, Gubio Soares Campos, Carlos Brites, Vitor Fortuna, Camila Alexandrina Figueiredo, Soraya Castro Trindade, Soraya Castro Trindade, Helton Estrela Ramos, Ryan dos Santos Costa   +25 more
doaj   +1 more source

IMGT^® Nomenclature of Engineered IGHG Variants Involved in Antibody Effector Properties and Formats

Antibodies, 2022
The constant region of the immunoglobulin (IG) or antibody heavy gamma chain is frequently engineered to modify the effector properties of the therapeutic monoclonal antibodies.
Marie-Paule Lefranc, Gérard Lefranc
doaj   +1 more source

Aire and Fezf2 Shape the Medullary Thymic Epithelial Cell Immunopeptidome for Central Tolerance

Immunology, EarlyView.
Central tolerance is shaped not merely by promiscuous gene expression in medullary thymic epithelial cells (mTECs), but by the subset of self‐peptides ultimately presented on MHC class II molecules. We propose a multilayered framework in which AIRE/Aire and FEZF2/Fezf2, together with specialised differentiation programmes—including thymic mimetic‐cell ...
Geraldo Aleixo Passos, Vitor Marcel Faça, Eduardo Antonio Donadi, Ana Paula Masson, Carlos Crippa Coletto, Gustavo Ronconi Roza   +5 more
wiley   +1 more source

Genomic and proteomic insights into hidradenitis suppurativa

Journal of the European Academy of Dermatology and Venereology, EarlyView.
A dual pathogenic model of HS involving both epithelial dysfunction and systemic inflammation is supported. The HLA‐DRA association hints at autoimmune overlap, but the proteomic signature which is dominated by innate immune mediators favours an autoinflammatory classification, which may guide future therapeutic strategies and patient stratification ...
Maria Argyropoulou, Emmanouil Stylianakis, Isis Ricaño‐Ponce, Nick Keur, Theodora Kanni, Dimitra Stergianou, Mihai G. Netea, Vinod Kumar, Evangelos J. Giamarellos‐Bourboulis   +8 more
wiley   +1 more source

Genes, fish and fisheries: translating science into policy

Journal of Fish Biology, EarlyView.
Abstract The 2024 Annual Symposium of the Fisheries Society of the British Isles reviewed the burgeoning impact of ‘omics’ technologies on fish ecology, management and forecasting. As with life sciences more generally, major advances in speed, cost‐effectiveness and breadth of applications in ‘omics’ has had profound societal and environmental impacts.
Gary R. Carvalho
wiley   +1 more source