Results 21 to 30 of about 21,232 (243)

Immunogenetics associated with severe coccidioidomycosis

JCI Insight, 2022
Disseminated coccidioidomycosis (DCM) is caused by Coccidioides, pathogenic fungi endemic to the southwestern United States and Mexico. Illness occurs in approximately 30% of those infected, less than 1% of whom develop disseminated disease.
Amy P. Hsu, Agnieszka Korzeniowska, Cynthia C. Aguilar, Jingwen Gu, Eric Karlins, Andrew J. Oler, Gang Chen, Glennys V. Reynoso, Joie Davis, Alexandria Chaput, Tao Peng, Ling Sun, Justin B. Lack, Derek J. Bays, Ethan R. Stewart, Sarah E. Waldman, Daniel A. Powell, Fariba M. Donovan, Jigar V. Desai, Nima Pouladi, Debra A. Long Priel, Daisuke Yamanaka, Sergio D. Rosenzweig, Julie E. Niemela, Jennifer Stoddard, Alexandra F. Freeman, Christa S. Zerbe, Douglas B. Kuhns, Yves A. Lussier, Kenneth N. Olivier, Richard C. Boucher, Heather D. Hickman, Jeffrey Frelinger, Joshua Fierer, Lisa F. Shubitz, Thomas L. Leto, George R. Thompson III, John N. Galgiani, Michail S. Lionakis, Steven M. Holland   +39 more
doaj   +1 more source

Antibody Subclass Repertoire and Graft Outcome following Solid Organ Transplantation

Frontiers in Immunology, 2016
Long-term outcomes in solid organ transplantation are constrained by the development of donor specific alloantibodies (DSA) against human leukocyte antigen (HLA) and other targets, which elicit antibody-mediated rejection (ABMR).
Nicole M Valenzuela, Michelle J Hickey, Elaine F Reed   +2 more
doaj   +1 more source

Exploration of the Noncoding Genome for Human-Specific Therapeutic Targets—Recent Insights at Molecular and Cellular Level

Cells, 2023
While it is well known that 98–99% of the human genome does not encode proteins, but are nevertheless transcriptionally active and give rise to a broad spectrum of noncoding RNAs [ncRNAs] with complex regulatory and structural functions, specific ...
Wolfgang Poller, Susmita Sahoo, Roger Hajjar, Ulf Landmesser, Anna M. Krichevsky   +4 more
doaj   +1 more source

Alloantibody Generation and Effector Function Following Sensitization To Human Leukocyte Antigen

Frontiers in Immunology, 2016
Allorecognition is the activation of the adaptive immune system to foreign Human Leukocyte Antigen (HLA) resulting in the generation of alloantibodies.
Michelle J Hickey, Nicole M Valenzuela, Elaine F Reed   +2 more
doaj   +1 more source

Contribution of HLA and KIR Alleles to Systemic Sclerosis Susceptibility and Immunological and Clinical Disease Subtypes

Frontiers in Genetics, 2022
Systemic sclerosis (SSc) is an autoinflammatory, fibrotic condition of unknown aetiology. The presence of detectable autoantibodies against diverse nuclear antigens, as well as strong HLA associations with disease, suggest autoimmune involvement, however
Aimee L. Hanson, Aimee L. Hanson, Joanne Sahhar, Gene-Siew Ngian, Janet Roddy, Jennifer Walker, Wendy Stevens, Wendy Stevens, Mandana Nikpour, Mandana Nikpour, Shervin Assassi, Susanna Proudman, Susanna Proudman, Maureen D. Mayes, Tony J. Kenna, Matthew A. Brown, Matthew A. Brown   +16 more
doaj   +1 more source

Lifelong medical challenges and immunogenetics of Turner syndrome [PDF]

Clinical and Experimental Pediatrics
Turner syndrome (TS) is a female phenotypic condition characterized by one or more typical clinical features and the partial or complete absence of a second X chromosome as determined by karyotype analysis.
Won Kyoung Cho
doaj   +1 more source

Correlation Between Immune-Related Genes and Tumor-Infiltrating Immune Cells With the Efficacy of Neoadjuvant Chemotherapy for Breast Cancer

Frontiers in Genetics, 2022
Background: In the absence of targeted therapy or clear clinically relevant biomarkers, neoadjuvant chemotherapy (NAC) is still the standard neoadjuvant systemic therapy for breast cancer.
Yan Zhou, Qi Tian, Huan Gao, Lizhe Zhu, Jiao Yang, Juan Zhang, Jin Yang   +6 more
doaj   +1 more source

Case Report: Cytomegalovirus Disease Is an Under-Recognized Contributor to Morbidity and Mortality in Common Variable Immunodeficiency

Frontiers in Immunology, 2022
BackgroundCommon Variable Immunodeficiency (CVID) is classified as a ‘Predominantly Antibody Deficiency’ (PAD), but there is emerging evidence of cellular immunodeficiency in a subset of patients.
Samantha Chan, Samantha Chan, Samantha Chan, Samantha Chan, Jack Godsell, Miles Horton, Miles Horton, Anthony Farchione, Lauren J. Howson, Lauren J. Howson, Mai Margetts, Celina Jin, Celina Jin, Celina Jin, Josh Chatelier, Josh Chatelier, Michelle Yong, Michelle Yong, Michelle Yong, Joseph Sasadeusz, Jo A. Douglass, Jo A. Douglass, Charlotte A. Slade, Charlotte A. Slade, Charlotte A. Slade, Vanessa L. Bryant, Vanessa L. Bryant, Vanessa L. Bryant   +27 more
doaj   +1 more source

Immunoglobulins: 25 Years of Immunoinformatics and IMGT-ONTOLOGY

Biomolecules, 2014
IMGT®, the international ImMunoGeneTics information system® (CNRS and Montpellier University) is the global reference in immunogenetics and immunoinformatics.
Marie-Paule Lefranc
doaj   +1 more source

Psoriasis: An Immunogenetic Perspective

Global Medical Genetics, 2022
Psoriasis is an erythematous-squamous dermatosis with a polygenic inheritance history. Both environmental and genetic factors play a role in the etiology of the disease.
Ayca Kocaaga, Mustafa Kocaaga
doaj   +1 more source