Results 31 to 40 of about 17,783 (180)

The immunogenetics of glomerulonephritis

Kidney International, 1994
There has been considerable interest in the ways in which inheritance might contribute to susceptibility of nephritis since the earliest attempts to understand its pathogenesis. This was first expressed by Wells [1] in 1812, who observed that the siblings of a child who developed nephritis after scarlet fever were much more likely to develop nephritis ...
openaire   +2 more sources

The Immunogenetic Conundrum of Preeclampsia [PDF]

Frontiers in Immunology, 2018
Pregnancy is an immunological challenge to the mother. The fetal tissues including the placenta must be protected from activation of the maternal immune system. On the other hand, the placental tissue sheds into the maternal circulation and must be adequately identified and phagocytized by the maternal immune system.
A. Inkeri Lokki, A. Inkeri Lokki, Jenni K. Heikkinen-Eloranta, Hannele Laivuori, Hannele Laivuori, Hannele Laivuori, Hannele Laivuori   +6 more
openaire   +4 more sources

Toll-Like Receptor-1 Single-Nucleotide Polymorphism 1805T/G Is Associated With Predisposition to Multibacillary Tuberculosis

Frontiers in Immunology, 2018
Tuberculosis (TB), caused by mycobacterial species of the Mycobacterium tuberculosis complex, is a serious global health issue. Brazil is among the 22 countries with the highest number of TB cases, and the state of Amazonas has the highest incidence of ...
Raphaela Honorato Barletta-Naveca, Raphaela Honorato Barletta-Naveca, Felipe Gomes Naveca, Felipe Gomes Naveca, Felipe Gomes Naveca, Felipe Gomes Naveca, Vanessa Alves de Almeida, Vanessa Alves de Almeida, Jorge Ivan Rebelo Porto, Jorge Ivan Rebelo Porto, George Allan Villarouco da Silva, Mauricio Morishi Ogusku, Aya Sadahiro, Aya Sadahiro, Aya Sadahiro, Rajendranath Ramasawmy, Rajendranath Ramasawmy, Rajendranath Ramasawmy, Antonio Luiz Boechat, Antonio Luiz Boechat   +19 more
doaj   +1 more source

Deep Immunophenotyping Reveals Distinct Immune Signatures in Axial Spondyloarthritis and Psoriatic Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA) are overlapping yet distinct conditions within the SpA spectrum. As divergent immunophenotypes may influence disease course and therapeutic response, we compared immune cell subsets, cytokine profiles, and inflammatory mediators.
Natalie Frede, Nils Craig‐Müller, Silke Kohrt, Marei‐Theresa Bott, Ulrich Salzer, Ana Cecilia Venhoff, Jens Thiel, Julia Frede, Reinhard E. Voll, Marta Rizzi, Raquel Lorenzetti, Nils Venhoff   +11 more
wiley   +1 more source

Immunogenetics

, 2022
This open access book explores techniques for working in the field of immunogenetics, i.e. fundamental and translational research into the adaptive immune receptor repertoire. Many chapters are dedicated to lab protocols, bioinformatics, and immunoinformatics analysis of high-resolution immunome analysis, exemplified by numerous applications ...
openaire   +2 more sources

The MHC Class Ia Genes in Chenfu’s Treefrog (Zhangixalus chenfui) Evolved via Gene Duplication, Recombination, and Selection

Animals, 2019
The molecular mechanisms underlying the evolution of adaptive immunity-related proteins can be deduced by a thorough examination of the major histocompatibility complex (MHC).
Hu Chen, Siqi Huang, Ye Jiang, Fuyao Han, Qingyong Ni, Yongfang Yao, Huailiang Xu, Sudhanshu Mishra, Mingwang Zhang   +8 more
doaj   +1 more source

Characterization of NAT2 Using Long‐Read Sequencing: Allele, Diplotype, and Phenotype Call Accuracy Compared to Other Testing Strategies

Clinical Pharmacology &Therapeutics, EarlyView.
The NAT2 pharmacogene is essential in drug metabolism, particularly for aromatic amines and hydrazines. Genetic variations in NAT2 categorize individuals as rapid, intermediate, or poor metabolizers based on their acetylation capacity to inform dosing guidelines.
Shobana John, Erin C. Boone, Byunggil Yoo, Laura B. Ramsey, Andrea Gaedigk   +4 more
wiley   +1 more source

Gingival inflammation and plaque accumulation affect therapeutic outcomes in patients with acne vulgaris

Journal of Periodontology, EarlyView.
Abstract Background We hypothesized that acne vulgaris (AV) and gingivitis were associated through systemic inflammatory mechanisms, sharing common etiological factors. This study aimed to identify the association between AV and gingivitis and to assess changes in acne severity in relation to changes in the plaque index (PI).
Ömer Faruk Okumuş, Mustafa Yazıcı, Alpdoğan Kantarci   +2 more
wiley   +1 more source

Analysis of immunogenetics interlaboratory comparisons’ success rates. External quality assurance system of the Spanish Society for Immunology GECLID-SEI

Frontiers in Genetics
Background:For many years, transplantation outcomes were uncertain and not hopeful, until histocompatibility testing spread. Common criteria for histocompatibility assays and communications’ improvement allowed an efficient organ sharing system.
M. Carmen Martín
doaj   +1 more source

HLA-DPB1*03 as Risk Allele and HLA-DPB1*04 as Protective Allele for Both Early- and Adult-Onset Multiple Sclerosis in a Hellenic Cohort

Brain Sciences, 2020
Background: Human Leucocyte Antigens (HLA) represent the genetic loci most strongly linked to Multiple Sclerosis (MS). Apart from HLA-DR and HLA–DQ, HLA-DP alleles have been previously studied regarding their role in MS pathogenesis, but to a much lesser
Maria Anagnostouli, Artemios Artemiadis, Maria Gontika, Charalampos Skarlis, Nikolaos Markoglou, Serafeim Katsavos, Konstantinos Kilindireas, Ilias Doxiadis, Leonidas Stefanis   +8 more
doaj   +1 more source