Results 31 to 40 of about 21,232 (243)

Comprehensive Analysis of the HLA Class I and the HLA class II Alleles in Patients with Takayasu Arteritis: Relationship with Clinical Patterns and Prognosis [PDF]

Iranian Journal of Immunology, 2021
Background: Takayasu arteritis (TA) is a systemic vasculitis, affecting mainly the aorta and its branches. Objective: To analyze the HLA class I and class II alleles in patients with TA and explore their relationship with clinical and demographic ...
Maja Stojanovic, Zorana Andric, Dusan Popadic, Marija Stankovic Stanojevic, Rada Miskovic, Dragana Jovanovic, Aleksandra Peric Popadic, Jasna Bolpacic, Vesna Tomic-Spiric, Sanvila Raskovic   +9 more
doaj   +1 more source

Extranodal marginal zone lymphoma clonotypes are detectable prior to eMZL diagnosis in tissue biopsies and peripheral blood of Sjögren’s syndrome patients through immunogenetics

Frontiers in Oncology, 2023
IntroductionActivated B cells play a key role in the pathogenesis of primary Sjögren’s syndrome (pSS) through the production of autoantibodies and the development of ectopic germinal centers in the salivary glands and other affected sites.
P. Martijn Kolijn, Erika Huijser, M. Javad Wahadat, M. Javad Wahadat, Cornelia G. van Helden-Meeuwsen, Paul L. A. van Daele, Paul L. A. van Daele, Zana Brkic, Jos Rijntjes, Konnie M. Hebeda, Patricia J. T. A. Groenen, Marjan A. Versnel, Rogier M. Thurlings, Anton W. Langerak   +13 more
doaj   +1 more source

Immunogenetics and transplantation [PDF]

Current Opinion in Immunology, 2010
It is well recognized that allospecific T cell activation is required for rejection. However, the process of allospecific T cell activation is largely controllable with current agents. Accordingly, short-term outcomes in allotransplantation have uniformly improved, a testament to the importance of the T cell-centric view of current therapy; thus, the ...
Allan, Kirk, Terry B, Strom
openaire   +2 more sources

A Clinical-Genetic Score to Identify Surgically Resected Colorectal Cancer Patients Benefiting From an Adjuvant Fluoropyrimidine-Based Therapy

Frontiers in Pharmacology, 2018
There are clinical challenges related to adjuvant treatment in colorectal cancer (CRC) and novel molecular markers are needed for better risk stratification of patients.
Elena De Mattia, Eva Dreussi, Marcella Montico, Sara Gagno, Chiara Zanusso, Luca Quartuccio, Salvatore De Vita, Michela Guardascione, Angela Buonadonna, Mario D’Andrea, Nicoletta Pella, Adolfo Favaretto, Enrico Mini, Stefania Nobili, Loredana Romanato, Erika Cecchin, Giuseppe Toffoli   +16 more
doaj   +1 more source

Immunogenetics and Personalized Vaccines: A New Era in Immunization

, 2023
Immunization has been one of the most significant medical achievements in history, saving countless lives by preventing infectious diseases. However, traditional vaccines are designed as one-size-fits-all solutions, often providing suboptimal protection ...
Pasderhsh Servushan
core   +1 more source

IMGT^® and 30 Years of Immunoinformatics Insight in Antibody V and C Domain Structure and Function

Antibodies, 2019
At the 10th Human Genome Mapping (HGM10) Workshop, in New Haven, for the first time, immunoglobulin (IG) or antibody and T cell receptor (TR) variable (V), diversity (D), joining (J), and constant (C) genes were officially recognized as ‘genes ...
Marie-Paule Lefranc, Gérard Lefranc
doaj   +1 more source

The immunogenetics of glomerulonephritis

Kidney International, 1994
There has been considerable interest in the ways in which inheritance might contribute to susceptibility of nephritis since the earliest attempts to understand its pathogenesis. This was first expressed by Wells [1] in 1812, who observed that the siblings of a child who developed nephritis after scarlet fever were much more likely to develop nephritis ...
openaire   +2 more sources

Clinical Spectrum and Outcomes of SOX1 Antibody‐Associated Paraneoplastic Neurological Syndromes: A Chinese Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background SOX1 antibody‐positive paraneoplastic neurological syndromes (PNS) exhibit significant population‐specific clinical heterogeneity. While Western cohorts predominantly manifest Lambert‐Eaton myasthenic syndrome (65%–80%), comprehensive clinical characterization and treatment response data in Asian populations remain critically ...
Jin‐Long Ye, Zu‐Ying Kuang, Bo Li, Meng‐Qiu Pan, Li‐Hua Zhou, Yang‐Yang Dai, Si‐Fen Xie, Xian‐Guang Lin, Ye‐Peng Hu, Li‐Hong Jiang, Zhan‐Hang Wang, Wei‐Jing Zhang   +11 more
wiley   +1 more source

14th International HLA and Immunogenetics Workshop: Report on the immunogenetics of aging

, 2021
The 'Immunogenetics of Aging' is a newly included component within the 14th International HLA and Immunogenetics Workshop. The aim of this component was to determine the contribution of human leukocyte antigen (HLA), cytokine genes and other major ...
Pawelec, G., Qguz, F., Bogunia-Kubik, K., Naumova, E., Carin, M., Ivanova, M., Constantinescu, I., Lange, A.   +7 more
core   +1 more source

Investigation of Genetic Susceptibility to Blastomycosis Reveals Interleukin-6 as a Potential Susceptibility Locus

mBio, 2019
Genetic differences are hypothesized to underlie ethnic disparities in incidence rates of the endemic systemic mycoses, including blastomycosis. Individuals of Hmong ancestry display elevated risk for this serious fungal infection.
Richard M. Merkhofer, Mary B. O’Neill, Donny Xiong, Nydiaris Hernandez-Santos, Hannah Dobson, J. Scott Fites, Abigail C. Shockey, Marcel Wuethrich, Caitlin S. Pepperell, Bruce S. Klein   +9 more
doaj   +1 more source