Results 11 to 20 of about 17,783 (180)

Pathogenesis of Non-Infectious Uveitis Elucidated by Recent Genetic Findings

Frontiers in Immunology, 2021
Uveitis is a generic term for inflammation of the uvea, which includes the iris, ciliary body, and choroid. Prevalence of underlying non-infectious uveitis varies by race and region and is a major cause of legal blindness in developed countries. Although
Masaki Takeuchi, Nobuhisa Mizuki, Shigeaki Ohno   +2 more
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Antibody Subclass Repertoire and Graft Outcome following Solid Organ Transplantation

Frontiers in Immunology, 2016
Long-term outcomes in solid organ transplantation are constrained by the development of donor specific alloantibodies (DSA) against human leukocyte antigen (HLA) and other targets, which elicit antibody-mediated rejection (ABMR).
Nicole M Valenzuela, Michelle J Hickey, Elaine F Reed   +2 more
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Immunogenetics associated with severe coccidioidomycosis

JCI Insight, 2022
Disseminated coccidioidomycosis (DCM) is caused by Coccidioides, pathogenic fungi endemic to the southwestern United States and Mexico. Illness occurs in approximately 30% of those infected, less than 1% of whom develop disseminated disease.
Amy P. Hsu, Agnieszka Korzeniowska, Cynthia C. Aguilar, Jingwen Gu, Eric Karlins, Andrew J. Oler, Gang Chen, Glennys V. Reynoso, Joie Davis, Alexandria Chaput, Tao Peng, Ling Sun, Justin B. Lack, Derek J. Bays, Ethan R. Stewart, Sarah E. Waldman, Daniel A. Powell, Fariba M. Donovan, Jigar V. Desai, Nima Pouladi, Debra A. Long Priel, Daisuke Yamanaka, Sergio D. Rosenzweig, Julie E. Niemela, Jennifer Stoddard, Alexandra F. Freeman, Christa S. Zerbe, Douglas B. Kuhns, Yves A. Lussier, Kenneth N. Olivier, Richard C. Boucher, Heather D. Hickman, Jeffrey Frelinger, Joshua Fierer, Lisa F. Shubitz, Thomas L. Leto, George R. Thompson III, John N. Galgiani, Michail S. Lionakis, Steven M. Holland   +39 more
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Exploration of the Noncoding Genome for Human-Specific Therapeutic Targets—Recent Insights at Molecular and Cellular Level

Cells, 2023
While it is well known that 98–99% of the human genome does not encode proteins, but are nevertheless transcriptionally active and give rise to a broad spectrum of noncoding RNAs [ncRNAs] with complex regulatory and structural functions, specific ...
Wolfgang Poller, Susmita Sahoo, Roger Hajjar, Ulf Landmesser, Anna M. Krichevsky   +4 more
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Alloantibody Generation and Effector Function Following Sensitization To Human Leukocyte Antigen

Frontiers in Immunology, 2016
Allorecognition is the activation of the adaptive immune system to foreign Human Leukocyte Antigen (HLA) resulting in the generation of alloantibodies.
Michelle J Hickey, Nicole M Valenzuela, Elaine F Reed   +2 more
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Lifelong medical challenges and immunogenetics of Turner syndrome [PDF]

Clinical and Experimental Pediatrics
Turner syndrome (TS) is a female phenotypic condition characterized by one or more typical clinical features and the partial or complete absence of a second X chromosome as determined by karyotype analysis.
Won Kyoung Cho
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Contribution of HLA and KIR Alleles to Systemic Sclerosis Susceptibility and Immunological and Clinical Disease Subtypes

Frontiers in Genetics, 2022
Systemic sclerosis (SSc) is an autoinflammatory, fibrotic condition of unknown aetiology. The presence of detectable autoantibodies against diverse nuclear antigens, as well as strong HLA associations with disease, suggest autoimmune involvement, however
Aimee L. Hanson, Aimee L. Hanson, Joanne Sahhar, Gene-Siew Ngian, Janet Roddy, Jennifer Walker, Wendy Stevens, Wendy Stevens, Mandana Nikpour, Mandana Nikpour, Shervin Assassi, Susanna Proudman, Susanna Proudman, Maureen D. Mayes, Tony J. Kenna, Matthew A. Brown, Matthew A. Brown   +16 more
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Correlation Between Immune-Related Genes and Tumor-Infiltrating Immune Cells With the Efficacy of Neoadjuvant Chemotherapy for Breast Cancer

Frontiers in Genetics, 2022
Background: In the absence of targeted therapy or clear clinically relevant biomarkers, neoadjuvant chemotherapy (NAC) is still the standard neoadjuvant systemic therapy for breast cancer.
Yan Zhou, Qi Tian, Huan Gao, Lizhe Zhu, Jiao Yang, Juan Zhang, Jin Yang   +6 more
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Case Report: Cytomegalovirus Disease Is an Under-Recognized Contributor to Morbidity and Mortality in Common Variable Immunodeficiency

Frontiers in Immunology, 2022
BackgroundCommon Variable Immunodeficiency (CVID) is classified as a ‘Predominantly Antibody Deficiency’ (PAD), but there is emerging evidence of cellular immunodeficiency in a subset of patients.
Samantha Chan, Samantha Chan, Samantha Chan, Samantha Chan, Jack Godsell, Miles Horton, Miles Horton, Anthony Farchione, Lauren J. Howson, Lauren J. Howson, Mai Margetts, Celina Jin, Celina Jin, Celina Jin, Josh Chatelier, Josh Chatelier, Michelle Yong, Michelle Yong, Michelle Yong, Joseph Sasadeusz, Jo A. Douglass, Jo A. Douglass, Charlotte A. Slade, Charlotte A. Slade, Charlotte A. Slade, Vanessa L. Bryant, Vanessa L. Bryant, Vanessa L. Bryant   +27 more
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Comprehensive Analysis of the HLA Class I and the HLA class II Alleles in Patients with Takayasu Arteritis: Relationship with Clinical Patterns and Prognosis [PDF]

Iranian Journal of Immunology, 2021
Background: Takayasu arteritis (TA) is a systemic vasculitis, affecting mainly the aorta and its branches. Objective: To analyze the HLA class I and class II alleles in patients with TA and explore their relationship with clinical and demographic ...
Maja Stojanovic, Zorana Andric, Dusan Popadic, Marija Stankovic Stanojevic, Rada Miskovic, Dragana Jovanovic, Aleksandra Peric Popadic, Jasna Bolpacic, Vesna Tomic-Spiric, Sanvila Raskovic   +9 more
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