Ir(III) Complexes Convert Cold to Hot Tumors via Ferroptosis/Necroptosis-Driven Immunogenic Cell Death and Photosensitized CD47 Downregulation. [PDF]
Yu LB +8 more
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Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu +4 more
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Bioinformatics and experimental animal model reveal the prognostic value of immunogenic cell death-related proteins in idiopathic pulmonary fibrosis. [PDF]
Li M +11 more
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Tumor targeting dendritic nanocarrier with immunogenic cell death inducing and TIGIT blockade for synergistic chemo-immunotherapy against TNBC. [PDF]
Wang J +11 more
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Integrative single-cell and machine learning approach to characterize immunogenic cell death and tumor microenvironment in LUAD. [PDF]
Zhang H +7 more
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Radiotherapy elicits immunogenic cell death and metabolic shifts in the tumor microenvironment: implications for immunotherapy. [PDF]
Hang ZS, Huang YY, Song A, Sun ZJ.
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Smad7 is a negative regulator of immunogenic cell death in colorectal cancer. [PDF]
Maresca C +8 more
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Immunogenic cell stress and death
Nature Immunology, 2022Dying mammalian cells emit numerous signals that interact with the host to dictate the immunological correlates of cellular stress and death. In the absence of reactive antigenic determinants (which is generally the case for healthy cells), such signals may drive inflammation but cannot engage adaptive immunity.
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Biomaterials That Induce Immunogenic Cell Death
Small Methods, 2023AbstractThe immune system takes part in most physiological and pathological processes of the body, including the occurrence and development of cancer. Immunotherapy provides a promising modality for inhibition and even the cure of cancer. During immunotherapy, the immunogenic cell death (ICD) of tumor cells induced by chemotherapy, radiotherapy ...
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