Results 91 to 100 of about 364,936 (336)

A modular protein language modelling approach to immunogenicity prediction.

PLoS Computational Biology
Neoantigen immunogenicity prediction is a highly challenging problem in the development of personalised medicines. Low reactivity rates in called neoantigens result in a difficult prediction scenario with limited training datasets.
Hugh O'Brien, Max Salm, Laura T Morton, Maciej Szukszto, Felix O'Farrell, Charlotte Boulton, Laurence King, Supreet Kaur Bola, Pablo D Becker, Andrew Craig, Morten Nielsen, Yardena Samuels, Charles Swanton, Marc R Mansour, Sine Reker Hadrup, Sergio A Quezada   +15 more
doaj   +1 more source

Immunogenicity Risk Assessment of Biotherapeutics Using an Ex Vivo B Cell Assay

Antibodies
Background/Objectives: Anti-drug antibody (ADA) formation can impact the safety, pharmacokinetics, and/or efficacy of biotherapeutics, including monoclonal antibodies (mAbs).
Kevin M. Budge, Ross Blankenship, Patricia Brown-Augsburger, Lukasz K. Chlewicki   +3 more
doaj   +1 more source

Immunogenic cell death

The International Journal of Developmental Biology, 2015
Currently, it is widely acknowledged that a proactive anticancer immunosurveillance mechanism takes part in the rejection of neoplastic lesions before they progress towards a benign or malignant tumour. However in cases of very aggressive neoplastic lesions consisting of cells with high mutational diversity, cancer cell variants might be formed that ...
Garg, Abhishek, Dudek-Peric, Aleksandra M., Romano, Erminia, Agostinis, Patrizia   +3 more
openaire   +4 more sources

Living Liquid Metal Composites Embedded with Electrogenic Endospores for Next‐Generation Bioelectronics

Advanced Functional Materials, EarlyView.
A new class of living liquid metal composites is introduced, embedding Bacillus subtilis endospores into eutectic gallium–indium (EGaIn). The spores enhance droplet coalescence, strengthen interfacial conductivity, and provide on‐demand electrogenic functionality after germination. The composites exhibit high conductivity, self‐healing, patternability,
Maryam Rezaie, Yang Gao, Seokheun Choi
wiley   +1 more source

Single step spray-dried polyelectrolyte microparticles enhance the antigen cross-presentation capacity of porcine dendritic cells [PDF]

, 2012
C
Baert, Kim, Cox, Eric, De Geest, Bruno, Devriendt, Bert, Dierendonck, Marijke, Favoreel, Herman, Remon, Jean Paul   +6 more
core   +1 more source

Preclinical immunogenicity risk assessment of biotherapeutics using CD4 T cell assays

Frontiers in Immunology
T-cell dependent antibody responses to biotherapeutics remain a challenge to the optimal clinical application of biotherapeutics because of their capacity to impair drug efficacy and their potential to cause safety issues.
Robin E. Walsh, Angela Nix, Chloé Ackaert, Aurélie Mazy, Jana Schockaert, Sofie Pattyn, Laurent Malherbe   +6 more
doaj   +1 more source

Preclinical Immunogenicity and Efficacy of a Multiple Antigen-Presenting System (MAPSTM) SARS-CoV-2 Vaccine [PDF]

, 2022
Cieslewicz Brian, Daniel Makrinos, Heidi Burke, Dara Bree, Renuka Haridas, Ian Tonkiss, Yannic C. Bartsch, Galit Alter, Richard Malley, Gilles Besin   +9 more
openalex   +1 more source

RNA‐Micelles as Self‐Assembling Structures for Efficient Co‐Delivery of Synergistic siRNA and Nucleoside Analogues to Treat CRC Lung Metastasis

Advanced Functional Materials, EarlyView.
Two kinds of self‐assembled RNA micelles were used to co‐deliver synergistic siRNA and nucleoside analogues for the treatment of colorectal cancer lung metastases. Near‐complete elimination of lung cancer metastases was confirmed in an orthotopic lung metastasis model constructed using human colorectal cancer lung metastases patient surgical samples to
Kai Jin, Piotr Rychahou, Daniel W. Binzel, B. Mark Evers, Peixuan Guo   +4 more
wiley   +1 more source

Immunogens and Antigen Processing: Report from a Global HIV Vaccine Enterprise Working Group [PDF]

, 2010
The Global HIV Vaccine Enterprise convened a meeting of a Working Group in July 2009 to discuss recent progress in rational design of the components of an HIV vaccine, such as inserts, vectors and adjuvants,and in understanding antigen processing and ...
John Mascola, Ralph Steinman, Richter C. King, the Working Group convened by the Global HIV Vaccine Enterprise   +3 more
core   +3 more sources

Bio‐Orthogonally Crosslinked Supramolecular Polymer Bottlebrush Hydrogels for Long‐Term 3D Cell Culture

Advanced Functional Materials, EarlyView.
Fibrous benzenetrispeptide (BTP) hydrogels, fabricated via strain‐promoted azide‐alkyne cycloaddition (SPAAC) crosslinking, form robust, bioinert networks. These hydrogels can support 3D cell culture, where cell viability and colony growth depend on the fiber content.
Ceren C. Pihlamagi, David Pretzel, Peer Nölte, Kourosh Rezaei, Ulrich S. Schubert, Johannes C. Brendel   +5 more
wiley   +1 more source