Results 61 to 70 of about 315,728 (345)

Phlebotomus perniciosus Recombinant Salivary Proteins Polarize Murine Macrophages Toward the Anti-Inflammatory Phenotype

Frontiers in Cellular and Infection Microbiology, 2020
Phlebotomus perniciosus (Diptera: Phlebotominae) is a medically and veterinary important insect vector. It transmits the unicellular parasite Leishmania infantum that multiplies intracellularly in macrophages causing life-threatening visceral diseases ...
Petra Sumova, Nikola Polanska, Tereza Lestinova, Tatiana Spitzova, Barbora Kalouskova, Ondrej Vanek, Petr Volf, Iva Rohousova   +7 more
doaj   +1 more source

Evaluation of safety and immunogenicity of duck-plague virus gC/gE double gene deletion

Frontiers in Immunology, 2022
Duck plague caused by duck plague virus (DPV) is a highly contagious disease that can cause serious morbidity and death in waterfowl such as ducks and geese, and bring huge economic losses to the duck industry.
Peilin Ruan, Peilin Ruan, Peilin Ruan, Xin Feng, Xin Feng, Xin Feng, Anchun Cheng, Anchun Cheng, Anchun Cheng, Mingshu Wang, Mingshu Wang, Mingshu Wang, Wei Zhang, Ying Wu, Ying Wu, Ying Wu, Qiao Yang, Qiao Yang, Qiao Yang, Bin Tian, Bin Tian, Bin Tian, Xuming Ou, Xuming Ou, Xuming Ou, Di Sun, Di Sun, Di Sun, Shaqiu Zhang, Shaqiu Zhang, Shaqiu Zhang, Sai Mao, Sai Mao, Sai Mao, Dekang Zhu, Dekang Zhu, Renyong Jia, Renyong Jia, Renyong Jia, Shun Chen, Shun Chen, Shun Chen, Mafeng Liu, Mafeng Liu, Mafeng Liu, Xin-Xin Zhao, Xin-Xin Zhao, Xin-Xin Zhao, Juan Huang, Juan Huang, Juan Huang, Qun Gao, Qun Gao, Qun Gao, Yanling Yu, Yanling Yu, Yanling Yu, Ling Zhang, Ling Zhang, Ling Zhang, Leichang Pan, Leichang Pan   +61 more
doaj   +1 more source

Impact of disease-modifying antirheumatic drugs on vaccine immunogenicity in patients with inflammatory rheumatic and musculoskeletal diseases

Annals of the Rheumatic Diseases, 2021
Patients with rheumatic diseases are at increased risk of infectious complications; vaccinations are a critical component of their care. Disease-modifying antirheumatic drugs may reduce the immunogenicity of common vaccines. We will review here available
M. Friedman, J. Curtis, K. Winthrop
semanticscholar   +1 more source

Algorithm for optimized mRNA design improves stability and immunogenicity [PDF]

Nature, 2020
An algorithm based on concepts established in computational linguistics enables rapid principled design of mRNA vaccines optimizing both structural stability and codon usage, resulting in improved half-life, protein expression and immune responses ...
He Zhang, Liang Zhang, Ang Lin, Congcong Xu, Ziyu Li, Kaibo Liu, Boxiang Liu, Xiaopin Ma, Fanfan Zhao, Huiling Jiang, Chunxiu Chen, Haifa Shen, Hangwen Li, D. Mathews, Yujian Zhang, Liang Huang   +15 more
semanticscholar   +1 more source

Immunogenicity of infliximab and adalimumab [PDF]

Expert Opinion on Drug Safety, 2019
TNF-α inhibitors have demonstrated efficacy both as monotherapy and in combination with disease-modifying anti-rheumatic drugs (DMARDs) in the treatment of chronic inflammatory immune-mediated dise...
Murdaca G., Negrini S., Greco M., Schiavi C., Giusti F., Borro M., Puppo F.   +6 more
openaire   +5 more sources

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Bacterial Immunogenicity Is Critical for the Induction of Regulatory B Cells in Suppressing Inflammatory Immune Responses

Frontiers in Immunology, 2020
B cells fulfill multifaceted functions that influence immune responses during health and disease. In autoimmune diseases, such as inflammatory bowel disease, multiple sclerosis and rheumatoid arthritis, depletion of functional B cells results in an ...
Jan Kevin Maerz, Constanze Trostel, Anna Lange, Raphael Parusel, Lena Michaelis, Andrea Schäfer, Hans Yao, Hanna-Christine Löw, Julia-Stefanie Frick   +8 more
doaj   +1 more source

Coronavirus immunogens

Veterinary Microbiology, 1993
Coronaviruses (CV) infect a variety of livestock, poultry and companion animals. They belong to at least five antigenic groups. CV cause localized infections of the respiratory and/or intestinal tracts, with the exception of feline infectious peritonitis virus (FIPV) and hemagglutinating encephalomyelitis (HEV) which cause systemic infections.
openaire   +2 more sources

The multiple roles of the NlpC_P60 peptidase family in mycobacteria – an underexplored target for antimicrobial drug discovery

FEBS Letters, EarlyView.
The NlpC_P60 superfamily of peptidases is recognised by its key role in bacterial cell wall homeostasis. Recently, studies have also described the involvement of NlpC_P60‐like enzymes in bacterial competitive mechanisms and pathogenesis across several lineages.
Catharina dos Santos Silva, Marcio Vinicius Bertacine Dias   +1 more
wiley   +1 more source

Characterization of CD8+ T-cell responses to non-anchor-type HLA class I neoantigens with single amino-acid substitutions

OncoImmunology, 2021
CD8+ T cells are capable of recognizing mutation-derived neoantigens displayed by HLA class I molecules, thereby exhibiting the ability to distinguish between cancer and normal cells. However, accumulating evidence has shown that only a small fraction of
Tomoyo Shinkawa, Serina Tokita, Munehide Nakatsugawa, Yasuhiro Kikuchi, Takayuki Kanaseki, Toshihiko Torigoe   +5 more
doaj   +1 more source