Results 61 to 70 of about 456,969 (387)

Satisfactory safety and immunogenicity of MSP3 malaria vaccine candidate in Tanzanian children aged 12-24 months. [PDF]

, 2009
BACKGROUND: Development and deployment of an effective malaria vaccine would complement existing malaria control measures. A blood stage malaria vaccine candidate, Merozoite Surface Protein-3 (MSP3), produced as a long synthetic peptide, has been shown ...
Bosomprah, Samuel, Chilengi, Roma, Cousens, Simon, Druilhe, Pierre, Francis, Filbert, Gesase, Samwel, Lemnge, Martha, Lusingu, John PA, Minja, Daniel, Msham, Salum, Noor, Ramadhani, Rutta, Acleus, Segeja, Method D, Sembuche, Samwel, Seth, Misago   +14 more
core   +2 more sources

Immunogenicity of Extracellular Vesicles

Advances in Materials
Extracellular vesicles (EVs) are promising next‐generation therapeutics and drug delivery systems due to demonstrated safety and efficacy in preclinical models and early‐stage clinical trials. There is an urgent need to address the immunogenicity of EVs (
Yutian Xia, Jianzhong Zhang, Gang Liu, Joy Wolfram   +3 more
semanticscholar   +1 more source

Immunogenicity Risk Profile of Nanobodies

Frontiers in Immunology, 2021
Nanobodies (Nbs), the variable domains of camelid heavy chain-only antibodies, are a promising class of therapeutics or in vivo imaging reagents entering the clinic.
Chloé Ackaert, Natalia Smiejkowska, C. Xavier, Yann G. J. Sterckx, S. Denies, B. Stijlemans, Y. Elkrim, N. Devoogdt, V. Caveliers, T. Lahoutte, S. Muyldermans, K. Breckpot, M. Keyaerts   +12 more
semanticscholar   +1 more source

Assessing the Immunogenicity of Biopharmaceuticals [PDF]

BioDrugs, 2016
Biopharmaceuticals have the potential to raise an immunogenic response in treated individuals, which may impact the efficacy and safety profile of these drugs. As a result, it is essential to evaluate immunogenicity throughout the different phases of the clinical development of a biopharmaceutical, including post-marketing surveillance.
Carlos Pineda, Daniel F. Alvarez, Claudio Carini, Ira Jacobs, Gilberto Castañeda Hernández   +4 more
openaire   +2 more sources

Immunogenicity of Endolysin PlyC

Antibiotics, 2022
Endolysins are bacteriolytic enzymes derived from bacteriophages. They represent an alternative to antibiotics, since they are not susceptible to conventional antimicrobial resistance mechanisms. Since non-human proteins are efficient inducers of specific immune responses, including the IgG response or the development of an allergic response mediated ...
Marek Adam Harhala, Katarzyna Gembara, Daniel C. Nelson, Paulina Miernikiewicz, Krystyna Dąbrowska   +4 more
openaire   +3 more sources

Randomized, Controlled Trial of the Long Term Safety, Immunogenicity and Efficacy of RTS,S/AS02(D) Malaria Vaccine in Infants Living in a Malaria-Endemic Region. [PDF]

, 2013
The RTS,S/AS malaria candidate vaccine is being developed with the intent to be delivered, if approved, through the Expanded Programme on Immunization (EPI) of the World Health Organization.
A Olotu, Ali Mohammed, Amanda Leach, B Lell, David Schellenberg, E Macete, EV Macete, Francisca Machera, Grace Mwangoka, Hassan Mshinda, J Sacarlal, J Sacarlal, JJ Aponte, Joe Cohen, Johan Vekemans, KA Bojang, KE Kester, KP Asante, Marc Lievens, Marcel Tanner, Marie-Claude Dubois, MedDRA, MT White, Mwanajaa Shomari, Nahya Salim, Omar Juma, P Aide, P Aide, P Bejon, Richard Kamata, S Abdulla, S Owusu-Agyei, Salim Abdulla, ST Agnandji, ST Agnandji, ST Agnandji, Sulende Kubhoja, Terrell Carter, Thomas Aebi, Tonya Villafana, W Ripley Ballou, WHO, WHO, WHO/IVR   +43 more
core   +5 more sources

Reducing Immunogenicity by Design: Approaches to Minimize Immunogenicity of Monoclonal Antibodies

BioDrugs
Monoclonal antibodies (mAbs) have transformed therapeutic strategies for various diseases. Their high specificity to target antigens makes them ideal therapeutic agents for certain diseases.
Chantal T Harris, Sivan Cohen
semanticscholar   +1 more source

Immunogenicity of infliximab and adalimumab [PDF]

Expert Opinion on Drug Safety, 2019
TNF-α inhibitors have demonstrated efficacy both as monotherapy and in combination with disease-modifying anti-rheumatic drugs (DMARDs) in the treatment of chronic inflammatory immune-mediated dise...
Murdaca G., Negrini S., Greco M., Schiavi C., Giusti F., Borro M., Puppo F.   +6 more
openaire   +5 more sources

The “animalization” influence on the specific activity of a live plague vaccine in the model animal experiments [PDF]

Ķazaķstannyṇ Klinikalyķ Medicinasy, 2016
Objective: Assessment of the “animalization” impact on the immunogenicity and viability of EV live plague vaccine. Methods: In this research we have used a vaccine strain of Yersinia pestis EV (a RIEH line), and a strain 231 from the National Depository ...
Tatyana Ponomarevа
doaj   +1 more source

Characterization of structural and immunological properties of a fusion protein between flagellin from Salmonella and lumazine synthase from Brucella [PDF]

, 2017
Aiming to combine the flexibility of Brucella lumazine synthase (BLS) to adapt different protein domains in a decameric structure and the capacity of BLS and flagellin to enhance the immunogenicity of peptides that are linked to their structure, we ...
Berguer, Paula Mercedes, Biedma, Marina Elizabeth, Blancá, Bruno Martin, Cayet, D., Errea, Agustina Juliana, Goldbaum, Fernando Alberto, Hiriart, Yanina, Moreno, Griselda Noemí, Rinaldi, Jimena Julieta, Rossi, Andrés Hugo, Rumbo, Martín, Sirard, J.C.   +11 more
core   +2 more sources