Results 71 to 80 of about 319,900 (371)

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Major Histocompatibility Complex Binding, Eluted Ligands, and Immunogenicity: Benchmark Testing and Predictions

Frontiers in Immunology, 2020
Antidrug antibody (ADA) responses impact drug safety, potency, and efficacy. It is generally assumed that ADA responses are associated with human leukocyte antigen (HLA) class II-restricted CD4+ T-cell reactivity.
Sinu Paul, Alba Grifoni, Bjoern Peters, Bjoern Peters, Alessandro Sette, Alessandro Sette   +5 more
doaj   +1 more source

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

Molecular Oncology, EarlyView.
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas, Konstantinos Voutetakis, Vivian Kosmidou, Spyridon Tsikalakis, Spyridon Roditis, Konstantinos Pateas, Ryangguk Kim, Kymberleigh Pagel, Stephan Wolf, Gregor Warsow, Antonia Dimitrakopoulou‐Strauss, Georgios N. Zografos, Alexander Pintzas, Johannes Betge, Olga Papadodima, Stefan Wiemann   +15 more
wiley   +1 more source

Crystal Structure and Immunogenicity of the DS-Cav1-Stabilized Fusion Glycoprotein From Respiratory Syncytial Virus Subtype B

Pathogens and Immunity, 2019
Background: Respiratory syncytial virus (RSV) subtypes, A and B, co-circulate in annual epidemics and alternate in dominance. We have shown that a subtype A RSV fusion (F) glycoprotein, stabilized in its prefusion conformation by DS-Cav1 mutations, is a
M. Gordon Joyce, Amy Bao, Man Chen, Ivelin S. Georgiev, Li Ou, Tatsiana Bylund, Aliaksandr Druz, Wing-Pui Kong, Dongjun Peng, Emily J. Rundlet, Joseph G. Van Galen, Shuishu Wang, Yongping Yang, Baoshan Zhang, Gwo-Yu Chuang, Jason S. McLellan, Barney S. Graham, John R. Mascola, Peter D. Kwong   +18 more
doaj   +1 more source

The Systematic Review and Meta-Analysis on the Immunogenicity and Safety of the Tuberculosis Subunit Vaccines M72/AS01E and MVA85A

Frontiers in Immunology, 2020
Background: Tuberculosis (TB) is a severe infectious disease with devastating effects on global public health. No TB vaccine has yet been approved for use on latent TB infections and healthy adults.
Inayat Ullah, Inayat Ullah, Shaheen Bibi, Shaheen Bibi, Shaheen Bibi, Ijaz Ul Haq, Safia, Kifayat Ullah, Long Ge, Xintong Shi, Xintong Shi, Ma Bin, Hongxia Niu, Hongxia Niu, Jinhui Tian, Bingdong Zhu, Bingdong Zhu   +16 more
doaj   +1 more source

Immunogenicity of the BNT162b2 vaccine in frail or disabled nursing home residents: COVID‐A study

Journal of The American Geriatrics Society, 2021
The safety and immunogenicity of the BNT162b2 coronavirus disease 2019 (COVID‐19) vaccine in older adults with different frailty and disability profiles have not been well determined. Our objective was to analyze immunogenicity of the BNT162b2 mRNA COVID‐
Sergio Salmerón Ríos, Marta Mas Romero, Elisa Belen Cortés Zamora, María Teresa Tabernero Sahuquillo, L. Romero Rizos, P. M. Sánchez-Jurado, G. Sánchez-Nievas, José Joaquín Blas Señalada, Inmaculada García Nogueras, Juan de Dios Estrella Cazalla, Fernando Andres-Pretel, Antonio Murillo Romero, V. M. Lauschke, J. Stebbing, P. Abizanda   +14 more
semanticscholar   +1 more source

Multiplex single‐cell profiling of putative cancer stem cell markers ALDH1, SOX9, SOX2, CD44, CD133 and CD15 in endometrial cancer

Molecular Oncology, EarlyView.
Cancer stem cells are associated with aggressive disease, but a deep characterization of such markers is lacking in endometrial cancer. This study uses imaging mass cytometry to explore putative cancer stem cell markers in endometrial tumors and corresponding organoid models.
Hilde E. Lien, Marta E. Hjelmeland, Hege F. Berg, Rose M. Gold, Kathrine Woie, Lars A. Akslen, Ingfrid S. Haldorsen, Camilla Krakstad   +7 more
wiley   +1 more source

Proceedings of the 15th European immunogenicity platform open symposium on immunogenicity of biopharmaceuticals

mAbs
The European Immunogenicity Platform (EIP) celebrated the 15th edition of its Open Symposium on Immunogenicity of Biopharmaceuticals and its associated one-day workshop on 22–24 February 2024 in Lisbon.
Sophie Tourdot, Karien Bloem, Lysie Champion, Anne S. De Groot, Axel Ducret, Patrick Garidel, Joanna Grudzinska-Goebel, Michael Gutknecht, Timothy Hickling, Frank Horling, Marina Ichetovkin, Alison Johnson, Issa Jyamubandi, Anette Karle, Arno Kromminga, Ebru Aydin Kurtulmus, Floris Loeff, Bernard Maillere, Lydia Michaut, Francesca Minelli, Morten Nielsen, Vivek Nayak, Robert Nelson, Marc Pallardy, Sofie Pattyn, Joao Pedras-Vasconelos, Elise Pepermans, Alain Poyau, Matthias Reichel, Amy Rosenberg, Zuben Sauna, Manisha Saxena, Noel Smith, Veerle Snoeck, Lester Thoo, Michael Tovey, Daniela Verthelyi, Rene Wuttke, Daniel Yerly, Daniel Kramer   +39 more
doaj   +1 more source

An Erythrocyte Membrane-Associated Antigen, PvTRAg-26 of Plasmodium vivax: A Study of Its Antigenicity and Immunogenicity

Frontiers in Public Health, 2020
Background:Plasmodium tryptophan-rich (TR) proteins have been proposed as potential vaccine candidate antigens. Among them, P. vivax tryptophan-rich antigens (PvTR-Ags), which have positionally conserved tryptophan residues in a TR domain, are highly ...
Liping Fan, Jinxing Xia, Jilong Shen, Qiang Fang, Qiang Fang, Hui Xia, Hui Xia, Meijuan Zheng, Jin-Hee Han, Eun-Taek Han, Bo Wang, Yuanhong Xu   +11 more
doaj   +1 more source

A bi-adjuvant nanovaccine that potentiates immunogenicity of neoantigen for combination immunotherapy of colorectal cancer

Science Advances, 2020
A rationally designed bi-adjuvant nanovaccine enhances neoantigen immunogenicity and enables combination immunotherapy. Neoantigen vaccines have been enthusiastically pursued for personalized cancer immunotherapy while vast majority of neoantigens have ...
Qianqian Ni, Fuwu Zhang, Yijing Liu, Zhantong Wang, Guocan Yu, B. Liang, G. Niu, Ting Su, G. Zhu, Guangming Lu, Longjiang Zhang, Xiaoyuan Chen   +11 more
semanticscholar   +1 more source