Results 71 to 80 of about 315,728 (345)

The solution supramolecular structure of α2 → 8 polysialic acid suggests a structural cause for its low immunogenicity

FEBS Letters, EarlyView.
α2 → 8 polysialic acid elicits poor immunogenicity. Small‐angle scattering shows a supramolecular structure with parallel‐chain binding, although in different forms at μm and mm calcium. The major histocompatibility complex requires molecular weights around 2000 Da to produce antibodies, and 2000 Da polysialic oligomers will bind in these structures ...
Kenneth A. Rubinson
wiley   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Immunogenicity of the BNT162b2 vaccine in frail or disabled nursing home residents: COVID‐A study

Journal of The American Geriatrics Society, 2021
The safety and immunogenicity of the BNT162b2 coronavirus disease 2019 (COVID‐19) vaccine in older adults with different frailty and disability profiles have not been well determined. Our objective was to analyze immunogenicity of the BNT162b2 mRNA COVID‐
Sergio Salmerón Ríos, Marta Mas Romero, Elisa Belen Cortés Zamora, María Teresa Tabernero Sahuquillo, L. Romero Rizos, P. M. Sánchez-Jurado, G. Sánchez-Nievas, José Joaquín Blas Señalada, Inmaculada García Nogueras, Juan de Dios Estrella Cazalla, Fernando Andres-Pretel, Antonio Murillo Romero, V. M. Lauschke, J. Stebbing, P. Abizanda   +14 more
semanticscholar   +1 more source

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

Molecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever, Renske D. M. Steenbergen   +1 more
wiley   +1 more source

The immunogenicity and safety of the new, Indonesian DTwP-HB-Hib vaccine compared to the DTwP/HB vaccine given with the Hib vaccine

Paediatrica Indonesiana, 2017
Background Haemophilus influenzae type b (Hib) causes infection with predominant manifestations of pneumonia, meningitis, and other invasive diseases, occurring primarily in children aged under 2 years, particularly in infants.
Novilia Sjafri Bachtiar, Kusnandi Rusmil, Sunarjati Sudigdoadi, Cissy B Kartasasmita, Hadyana Hadyana   +4 more
doaj   +1 more source

On the definition of a criterion of immunogenicity [PDF]

Proceedings of the National Academy of Sciences, 2006
The main objective of immunology is to establish why and when an immune response occurs, that is, to determine a criterion of immunogenicity. According to the consensus view, the proper criterion of immunogenicity lies in the discrimination between self and nonself.
Pradeu, Thomas, Carosella, Edgardo
openaire   +4 more sources

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

A bi-adjuvant nanovaccine that potentiates immunogenicity of neoantigen for combination immunotherapy of colorectal cancer

Science Advances, 2020
A rationally designed bi-adjuvant nanovaccine enhances neoantigen immunogenicity and enables combination immunotherapy. Neoantigen vaccines have been enthusiastically pursued for personalized cancer immunotherapy while vast majority of neoantigens have ...
Qianqian Ni, Fuwu Zhang, Yijing Liu, Zhantong Wang, Guocan Yu, B. Liang, G. Niu, Ting Su, G. Zhu, Guangming Lu, Longjiang Zhang, Xiaoyuan Chen   +11 more
semanticscholar   +1 more source

Immunogenicity of Extended mRNA SARS-CoV-2 Vaccine Dosing Intervals.

Journal of the American Medical Association (JAMA), 2021
Immunogenicity of Extended mRNA SARS-CoV-2 Vaccine Dosing Intervals Standard dosing intervals for BNT162b2 and mRNA-1273 SARSCoV-2 vaccines are 21 and 28 days, respectively.1 Data suggest improved effectiveness of ChAdOx1 adenoviral2 and other ...
B. Grunau, D. Goldfarb, Michael Asamoah-Boaheng, L. Golding, T. Kirkham, P. Demers, P. Lavoie   +6 more
semanticscholar   +1 more source

Immunogenicity of targeted lentivectors

Oncotarget, 2014
To increase the safety and possibly efficacy of HIV-1 derived lentivectors (LVs) as an anti-cancer vaccine, we recently developed the Nanobody (Nb) display technology to target LVs to antigen presenting cells (APCs). In this study, we extend these data with exclusive targeting of LVs to conventional dendritic cells (DCs), which are believed to be the ...
Goyvaerts, Cleo, De Groeve, Kurt, Van Lint, Sandra, Heirman, Carlo, Vanginderachter, Jo A, De Baetselier, Patrick, Raes, Geert, Thielemans, Kris, Breckpot, Karine   +8 more
openaire   +6 more sources