Results 41 to 50 of about 1,199,652 (392)

Dose, exposure, and treatment regimen of intravenous immunoglobulin G in multifocal motor neuropathy

Frontiers in Neurology
IntroductionIntravenous immunoglobulin (IVIG) is the only approved treatment for multifocal motor neuropathy (MMN), a rare, chronic, immune-mediated demyelinating neuropathy. There is a significant gap in understanding of the role of serum immunoglobulin
Zhaoyang Li, Stefan Roepcke, Ryan Franke, Leman Yel   +3 more
doaj   +1 more source

Immunoglobulin deposition on biomolecule corona determines complement opsonisation efficiency of preclinical and clinical nanoparticles

Nature Nanotechnology, 2018
Deposition of complement factors (opsonization) on nanoparticles may promote clearance from the blood by macrophages and trigger proinflammatory responses, but the mechanisms regulating the efficiency of complement activation are poorly understood.
V. Vu, Geoffrey B. Gifford, Fangfang Chen, Halli Benasutti, Guankui Wang, E. Groman, R. Scheinman, L. Saba, S. Moghimi, D. Simberg   +9 more
semanticscholar   +1 more source

Diversity of immunoglobulin light chain genes in non-teleost ray-finned fish uncovers IgL subdivision into five ancient isotypes [PDF]

, 2018
The aim of this study was to fill important gaps in the evolutionary history of immunoglobulins by examining the structure and diversity of IgL genes in non-teleost ray-finned fish.
Andreyushkova, Daria A, Baranov, Konstantin O, Chikaev, Nikolai A, Gessner, Jörn, Guselnikov, Sergey V, Kulemzin, Sergey V, Makunin, Alexey I, Mechetina, Ludmila V, Najakshin, Alexander M, Schartl, Manfred, Stöck, Matthias, Taranin, Alexander V, Trifonov, Vladimir A, Warren, Wesley C, Wuertz, Sven   +14 more
core   +5 more sources

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Antigen Presentation Profiling Reveals Recognition of Lymphoma Immunoglobulin Neoantigens

Nature, 2017
Cancer somatic mutations can generate neoantigens that distinguish malignant from normal cells. However, the personalized identification and validation of neoantigens remains a major challenge.
M. Khodadoust, N. Olsson, Lisa E. Wagar, O. Haabeth, Binbin Chen, Kavya Swaminathan, Keith Rawson, C. Liu, D. Steiner, P. Lund, Samhita Rao, Lichao Zhang, C. Marceau, H. Stehr, Aaron M. Newman, D. Czerwinski, V. Carlton, M. Moorhead, M. Faham, H. Kohrt, J. Carette, Michael R. Green, Mark M. Davis, Ronald Levy, Joshua E. Elias, Ash A. Alizadeh   +25 more
semanticscholar   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Oregano Essential Oil as a Natural Plant Additive Affects Growth Performance and Serum Antibody Levels by Regulating the Rumen Microbiota of Calves

Animals
This experiment aimed to investigate whether supplementation of calves with different doses of oregano essential oil (OEO) could promote the development of the gastrointestinal tract and enhance the immune ability of calves by regulating the rumen ...
Zhihao Luo, Ting Liu, Dongzhu Cairang, Shuru Cheng, Jiang Hu, Bingang Shi, Hui Zhu, Huan Chen, Tao Zhang, Xuejiao Yi   +9 more
doaj   +1 more source

Celebrating More Than a Century of Research on Antibodies: Affirmation Through Negation via Complex Formation

Pathogens and Immunity, 2017
In this brief commentary, I highlight the remarkable properties of antibodies (also known as immunoglobulins) revealed by more than 100 years of biomedical research.
Neil S. Greenspan
doaj   +1 more source

IgBLAST: an immunoglobulin variable domain sequence analysis tool

Nucleic Acids Res., 2013
The variable domain of an immunoglobulin (IG) sequence is encoded by multiple genes, including the variable (V) gene, the diversity (D) gene and the joining (J) gene.
Jian Ye, Ning Ma, Thomas L. Madden, J. Ostell   +3 more
semanticscholar   +1 more source

Expression of the Thyroid Hormone Receptor Gene, erbAα, in B Lymphocytes: Alternative mRNA Processing is Independent of Differentiation but Correlates with Antisense RNA Levels [PDF]

, 1997
The erbAα gene encodes two α-thyroid hormone receptor isoforms, TRα1 and TRα2, which arise from alternatively processed mRNAs, erbAα1 (α1) and erb α2 (α2).
Hastings, Michelle Laura, Martincic, Kathlee, Milcarek, Christine, Munroe, Stephen H., Peterson, Martha L.   +4 more
core   +1 more source