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Mucosal immunity provides a potential for preventing initial infection and stopping subsequent transmission of SARS-CoV-2. Here, we examined the safety and immunogenicity of a replication-defective adenovirus type-5 vectored vaccine (Ad5-nCov) encoding ...
Fang Xu+7 more
doaj +1 more source
Salivary immunoglobulin A (sIgA) has been proposed as a potential indicator of welfare for various species, including Asian elephants, and may be related to adrenal cortisol responses.
Tithipong Plangsangmas+7 more
doaj +1 more source
Immunoglobulins and immunoglobulin subclasses in the elderly [PDF]
Background: Published data imply that adult concentrations are achieved for all Ig isotypes and plateau by 15--18 years of age. Recent data, however, suggest that these results are not applicable in the elderly. There are no equivalent data for IgG subclasses.
Robert J Lock, David J Unsworth
openaire +3 more sources
Pseudomonas aeruginosa is pathogenic in immunocompromised individuals. It has several complex mechanisms for evading human immunity. The objective of the study was to examine the secretory immunoglobulin A (sIgA) mediated immune response in saliva to ...
Wan Keqiang+3 more
doaj +1 more source
Role of the intestinal MALT in pathogenesis of the IgA-nephropathy
Modern view on pathogenesis of immunoglobulin (Ig)A-nephropathy and possible relation to intestinal MALT-system activity is presented in the article. Aberrant glycosylation of IgA and increased association of IgA-nephropathy with intestinal diseases or ...
Sergei V. Guliaev+3 more
doaj +1 more source
Assessment of age-related changes of salivary immunoglobulin a levels among healthy individuals
Background: Secretory immunoglobulin A (IgA) is the first line of defense against pathogens that invade mucosal surfaces. It has been reported that the immune system exhibits profound age-related changes.
Manishkumar Dinkar Shete+5 more
doaj +1 more source
Severity of foot process effacement is associated with proteinuria in patients with IgA nephropathy
Background : : Proteinuria is a significant risk factor for progression of IgA nephropathy (IgAN) and has a positive correlation with severity of foot process effacement (FPE).
Ji-Hye Lee+7 more
doaj +1 more source
Learning the heterogeneous hypermutation landscape of immunoglobulins from high-throughput repertoire data [PDF]
Somatic hypermutations of immunoglobulin (Ig) genes occuring during affinity maturation drive B-cell receptors' ability to evolve strong binding to their antigenic targets. The landscape of these mutations is highly heterogeneous, with certain regions of the Ig gene being preferentially targeted. However, a rigorous quantification of this bias has been
arxiv +1 more source
Sialendoscopic management of autoimmune sialadenitis: a review of literature [PDF]
Autoimmune diseases of major salivary glands include Sjögren's syndrome and a complex of disorders classified as immunoglobulin G4-related diseases.
DE VINCENTIIS, Marco+6 more
core +2 more sources
Purification and Characterisation of Badger IgA and Its Detection in the Context of Tuberculosis
European badgers are a wildlife reservoir of bovine tuberculosis in parts of Great Britain. Accurate diagnosis of tuberculosis in badgers is important for the development of strategies for the control of the disease.
Deanna Dalley+3 more
doaj +1 more source