Immunoglobulins and immunoglobulin subclasses in the elderly [PDF]
Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 2003 Background: Published data imply that adult concentrations are achieved for all Ig isotypes and plateau by 15--18 years of age. Recent data, however, suggest that these results are not applicable in the elderly. There are no equivalent data for IgG subclasses.
Robert J Lock, David J Unsworth
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Severity of foot process effacement is associated with proteinuria in patients with IgA nephropathy
Kidney Research and Clinical Practice, 2020 Background : : Proteinuria is a significant risk factor for progression of IgA nephropathy (IgAN) and has a positive correlation with severity of foot process effacement (FPE).
Ji-Hye Lee +7 more
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Türk Biyokimya Dergisi, 2023 Pseudomonas aeruginosa is pathogenic in immunocompromised individuals. It has several complex mechanisms for evading human immunity. The objective of the study was to examine the secretory immunoglobulin A (sIgA) mediated immune response in saliva to ...
Wan Keqiang +3 more
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Purification and Characterisation of Badger IgA and Its Detection in the Context of Tuberculosis
Veterinary Sciences, 2019 European badgers are a wildlife reservoir of bovine tuberculosis in parts of Great Britain. Accurate diagnosis of tuberculosis in badgers is important for the development of strategies for the control of the disease.
Deanna Dalley +3 more
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Learning the heterogeneous hypermutation landscape of immunoglobulins from high-throughput repertoire data [PDF]
Nucleic Acids Research 48 (19) 10702-10712 (2020), 2020 Somatic hypermutations of immunoglobulin (Ig) genes occuring during affinity maturation drive B-cell receptors' ability to evolve strong binding to their antigenic targets. The landscape of these mutations is highly heterogeneous, with certain regions of the Ig gene being preferentially targeted. However, a rigorous quantification of this bias has been
arxiv +1 more source
Role of the intestinal MALT in pathogenesis of the IgA-nephropathy
Терапевтический архив, 2021 Modern view on pathogenesis of immunoglobulin (Ig)A-nephropathy and possible relation to intestinal MALT-system activity is presented in the article. Aberrant glycosylation of IgA and increased association of IgA-nephropathy with intestinal diseases or ...
Sergei V. Guliaev +3 more
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Learning the statistics and landscape of somatic mutation-induced insertions and deletions in antibodies [PDF]
, 2021 Affinity maturation is crucial for improving the binding affinity of antibodies to antigens. This process is mainly driven by point substitutions caused by somatic hypermutations of the immunoglobulin gene. It also includes deletions and insertions of genomic material known as indels.
arxiv +1 more source
Assessment of age-related changes of salivary immunoglobulin a levels among healthy individuals
Journal of Pharmacy and Bioallied Sciences, 2021 Background: Secretory immunoglobulin A (IgA) is the first line of defense against pathogens that invade mucosal surfaces. It has been reported that the immune system exhibits profound age-related changes.
Manishkumar Dinkar Shete +5 more
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Dynamic immunoglobulin responses to gut bacteria during inflammatory bowel disease
Gut Microbes, 2020 Aberrant immune responses against gut microbiota are thought to be key drivers of inflammatory bowel disease (IBD) pathogenesis. However, the extent and targets of immunoglobulin (Ig) A versus IgG responses to gut bacteria in IBD and its association with
Sunaina Rengarajan +7 more
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A case of monoclonal gammopathy of renal significance presenting as atypical amyloidosis with IgA lambda paraproteinemia [PDF]
Journal of Pathology and Translational Medicine, 2020 Monoclonal gammopathy of renal significance is defined as any B cell or plasma cell clonal lymphoproliferation which neither causes tumor complications nor meets any current hematological criteria for specific therapy, with one or more kidney lesions ...
Chankyung Kim +3 more
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