Results 51 to 60 of about 113,982,624 (231)

Update on treatment of immunoglobulin A nephropathy [PDF]

Nephrology, 2018
ABSTRACTImmunoglobulin A nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide and the most common cause of end‐stage renal disease in young adults. However, there are still no specific therapies capable of targeting key pathways involved in disease pathogenesis.
Yue-Miao, Zhang, Hong, Zhang
openaire   +2 more sources

Multi‐omics–driven precision medicine

iMeta, EarlyView.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source

The critical role of methylglyoxal and glyoxalase 1 in diabetic nephropathy [PDF]

, 2014
The discovery of increased formation of methylglyoxal (MG) by cell metabolism in high glucose concentration in vitro suggested possible relevance to diabetes and diabetes complications (1,2).
Rabbani, Naila, Thornalley, Paul J.
core   +1 more source

Relapses or de-novo IgA nephropathy following COVID-19 vaccination; a narrative review [PDF]

, 2023
Immunoglobulin A (IgA) nephropathy is the most common type of glomerulonephritis worldwide characterized by excessive serum levels of glycosylated which triggers the generation of glycan-specific IgG and IgA autoantibodies.
Shahrzad Alimohammadi, Hamid Reza Jahantigh, Maryam Khosravian, Hafizi, Masoud, Alimohammadi, Shahrzad, Jahantigh, Hamid Reza, Masoud Hafizi, Payam Peymani, Khosravian, Maryam, Peymani, Payam, Shokouh Shayanpour, Shayanpour, Shokouh   +11 more
core   +2 more sources

Efficacy and safety of mycophenolate mofetil in patients with IgA nephropathy: an update meta-analysis

BMC Nephrology, 2017
Background The application of mycophenolate mofetil (MMF) in treating patients with immunoglobulin A nephropathy (IgAN) remains uncertain. This update meta-analysis was performed to re-evaluate the therapeutic potential of MMF in IgAN.
Bing Du, Ye Jia, Wenhua Zhou, Xu Min, Lining Miao, Wenpeng Cui   +5 more
doaj   +1 more source

Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág, Krisztián Márk Karvaly, Alexandra Molnár, Mirjam Balbisi, Júlia Németh, Lilla Turiák   +5 more
wiley   +1 more source

Pregnancy in a woman with recurrent immunoglobulin a nephropathy: A case report [PDF]

, 2018
Immunoglobulin A nephropathy (IgAN) is the most common form of primary glomerulonephritis and is increasingly encountered in pregnancy. The obstetric and renal outcomes of pregnancy are controversial, however.
L. Colla, Carosso, A., M. Zonca, L. Daniele, Zonca, Marina, Borella, Fulvio, Benedetto, C., A. Carosso, F. Borella, C. Benedetto   +9 more
core   +1 more source

Machine-learning-based identification of patients with IgA nephropathy using a computerized medical billing database.

PLoS ONE
The billing database of the universal healthcare system in Japan potentially includes large-cohort data of patients with immunoglobulin A nephropathy, diagnosis codes aimed at billing should not be directly used for clinical research because of the risk ...
Ryoya Tsunoda, Keitaro Kume, Rina Kagawa, Masaru Sanuki, Hiroyuki Kitagawa, Kaori Mase, Kunihiro Yamagata   +6 more
doaj   +1 more source

IgG Subclass (IgG1‐4) and IgA Autoantibody Profiles Against Muscle‐Specific Kinase in a Greek Cohort

Muscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims Muscle‐specific kinase myasthenia gravis (MuSK‐MG) is an autoimmune neuromuscular disorder predominantly mediated by IgG4 autoantibodies disrupting MuSK signaling. The contribution of other isotypes remains incompletely defined. We characterized the serological profile of a Greek cohort of MuSK‐MG patients.
Sofia‐Natsοuko Gkotzamani, Maria Pechlivanidou, Francisca Faber, Cansu Elmas, Vasiliki Zouvelou, Elisabeth Chroni, Dimitrios Tzanetakos, Maria Kourouvani, Marlene Wolfsgruber, Ioannis Zaganas, Dimitra Kolovou, Michael Rentzos, Ariadne Daponte, Maria Chondrogiorgi, Spyridon Konitsiotis, Georgios Nicolaou, Stavroula Salakou, Sotirios Giannopoulos, Konstandinos Lazaridis, Georgios Tsivgoulis, Socrates Tzartos, Inga Koneczny, John S. Tzartos   +22 more
wiley   +1 more source

Correlation between serum Klotho and uromodulin expression levels and IgA nephropathy complicated with hyperuricemia

Linchuang shenzangbing zazhi
Objective To explore the correlation between the expression levels of serum Klotho and uromodulin （UMOD） and immunoglobulin A （IgA） nephropathy complicated with hyperuricemia.
Di Wei, Li-min Jia, Cui Zhao, Xiao-fang Fang   +3 more
doaj   +1 more source