Results 31 to 40 of about 113,982,624 (231)

Pathological Copper Overload Reprograms SOD1 Activation via COMMD1 to Promote Senescence and Fibrosis

Advanced Science, EarlyView.
This study uncovers a previously unrecognized copper‐COMMD1‐SOD1 regulatory axis, revealing that pathological copper overload paradoxically suppresses SOD1 activity by promoting COMMD1‐dependent disruption of SOD1 homodimerization. These findings redefine the regulatory role of copper in SOD1 biology and provide novel mechanistic insight into the ...
Yuqing Liu, Jing Liu, Wenqian Zhou, Yangyang Niu, Yan Zheng, Yiguo Liu, Yingying Zhang, Chen Yu   +7 more
wiley   +1 more source

ANGPTL4 Exacerbates Renal Injury in Diabetic Kidney Disease by Impairing Podocyte Lipophagy via Compromised Lysosomal Degradative Function

Advanced Science, EarlyView.
In diabetic kidney disease, elevated podocyte ANGPTL4 is linked to reduced TFEB nuclear localization and compromised lysosomal degradative function. These changes impair podocyte lipophagy and promote lipid‐droplet accumulation and podocyte injury, which may contribute to renal injury progression.
Xiaojing Liu, Shimin Jiang, Zhenkun Yang, Shunlai Shang, Jiayi Li, Guming Zou, Cheng Zhou, Wenge Li   +7 more
wiley   +1 more source

Unmasking of immunoglobulin a deposits posttransplant due to COVID-19 AKI-incidental or causal – A nephrologists' dilemma a case report

Indian Journal of Transplantation, 2022
COVID-19 is a global pandemic with the chronically immunosuppressed transplant recipients being the most vulnerable both to infection as well as complications of COVID-19.
Luvdeep Dogra, Manisha Sahay, Kiranmai Ismal, P S Vali   +3 more
doaj   +1 more source

THSD7A Exacerbates Atherosclerosis via Activation of Signaling Axis αvβ3/CEBPD/IL1A

Advanced Science, EarlyView.
THSD7A exerts pro‐inflammatory effects and exacerbates atherosclerosis. Mechanistically, THSD7A regulates endothelial cell inflammation and atherosclerosis by activating the αvβ3/CEBPD/IL1A signaling axis. THSD7A is not only a genetic marker but also a potential therapeutic target for coronary artery disease (CAD).
Jiankun Liu, Hongfei Liu, Yiqi Wan, Andong Wu, Jiayu Qiu, Xueting Gong, Ya Zhao, Yuanyuan Li, Bingbing Zhou, Yangyi Zheng, Fang Wu, Yuanzheng Zhu, Weixin Lv, Xueer Li, Qiang Yuan, Xiao‐Li Tian   +15 more
wiley   +1 more source

Immunoglobulin a nephropathy and renal transplantation

, 1999
In this review, we discuss the incidence of immunoglobulin A (IgA) mesangial deposits and IgA mesangial nephritis recurring in renal transplants in those patients whose renal failure was caused by IgA nephropathy (IgAN) or Henoch-Schönlein purpura.
Bannister, K., Faull, R., Elias, T., Clarkson, A.   +3 more
core   +1 more source

Clinical, Histopathological Profile and Treatment Outcomes of Immunoglobulin A Nephropathy: A Single-center Retrospective Study from South India

Indian Journal of Kidney Diseases
Background: Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis worldwide, with variable clinical presentations and outcomes.
Siddharth Herur, Vishnukeerthana Kotha, Vijay Chander Bukka, Megha S. Uppin, Srinivas Naidu Kinjarapu, Megha Saigal, Phanisree Alaparthi, Gangadhar Taduri, Swarnalatha Guditi   +8 more
doaj   +1 more source

The Study of Angptl4-Modulated Podocyte Injury in IgA Nephropathy

Frontiers in Physiology, 2021
BackgroundIncreasing evidence shows that Angptl4 affects proteinuria in podocytes injured kidney disease, however, whether there is a relationship between Angptl4 and IgA nephropathy (IgAN) has not been studied yet.MethodsPlasma and urine samples were ...
Sha Jia, Sha Jia, Sha Jia, Sha Jia, Sha Jia, Sha Jia, Xiaofeng Peng, Xiaofeng Peng, Xiaofeng Peng, Xiaofeng Peng, Xiaofeng Peng, Ludan Liang, Ludan Liang, Ludan Liang, Ludan Liang, Ludan Liang, Ying Zhang, Ying Zhang, Ying Zhang, Ying Zhang, Ying Zhang, Meng Li, Meng Li, Meng Li, Meng Li, Meng Li, Qin Zhou, Qin Zhou, Qin Zhou, Qin Zhou, Qin Zhou, Xiujin Shen, Xiujin Shen, Xiujin Shen, Xiujin Shen, Xiujin Shen, Yucheng Wang, Yucheng Wang, Yucheng Wang, Yucheng Wang, Yucheng Wang, Cuili Wang, Cuili Wang, Cuili Wang, Cuili Wang, Cuili Wang, Shi Feng, Shi Feng, Shi Feng, Shi Feng, Shi Feng, Jianghua Chen, Jianghua Chen, Jianghua Chen, Jianghua Chen, Jianghua Chen, Pingping Ren, Pingping Ren, Pingping Ren, Pingping Ren, Pingping Ren, Hong Jiang, Hong Jiang, Hong Jiang, Hong Jiang, Hong Jiang   +65 more
doaj   +1 more source

The GPX3‐VCAM1 Axis Gates Pro‐Fibrotic Tubule Cell Fate in Hyperuricemic Nephropathy

Advanced Science, EarlyView.
Hyperuricemia induces NLRP3 inflammasome signaling activation and downregulation of GPX3 in proximal tubular epithelial cells, leading to oxidative stress–driven VCAM1 upregulation, emergence of pro‐fibrotic proximal tubule cells, macrophage recruitment, and renal fibrosis.
Yunfei Qi, Qiang Zhao, Yue Lve, Yaming Yuan, Tingting Zhou, Yue Yuan, Dexi Wu, Yifan Tang, Yan Liu, Zhigang Li, Chunping Jiang, Qiurong Ding   +11 more
wiley   +1 more source

Clinical, genetic and molecular aspects of membranous nephropathy [PDF]

, 2011
Membranous Nephropathy (MN) is one of the leading causes of end-stage renal disease (ESRD). MN is an autoimmune disease in which autoantibodies target antigens at the level of the glomerular basement membrane.
Stanescu, H.C.
core  

IgG Glycosylation‐Dependent CLEC7A Signaling Drives Podocyte Dysfunction in Lupus Nephritis

Arthritis &Rheumatology, EarlyView.
Objective Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus (SLE) that can lead to end‐stage kidney disease and increased mortality. IgG from patients with LN displays abnormal glycosylation, contributing to podocyte injury.
Rohit Upadhyay, Alexia Orellana, George C. Tsokos, Rhea Bhargava   +3 more
wiley   +1 more source