Results 221 to 230 of about 57,044 (253)

The hinge region of the CD8α chain: structure, antigenicity, and utility in expression of immunoglobulin superfamily domains

International Immunology, 1992
The lymphocyte surface CD8 antigen is a heterodimer with each chain containing a single Ig-related domain, a hinge-like sequence, a transmembrane segment, and a short cytoplasmic sequence. A soluble form of the rat CD8 alpha chain was produced by introducing a stop codon into the cDNA at the end of the region encoding the extracellular sequence and ...
B J, Classon, M H, Brown, D, Garnett, C, Somoza, A N, Barclay, A C, Willis, A F, Williams   +6 more
openaire   +2 more sources

Dissection of the extracellular human interferon .gamma. receptor .alpha.-chain into two immunoglobulin-like domains. Production in an Escherichia coli thioredoxin gene fusion expression system and recognition by neutralizing antibodies

Biochemistry, 1995
The extracellular interferon gamma receptor alpha-chain (IFN gamma R) is believed to comprise two discrete approximately 110 amino acid immunoglobulin-like domains, perhaps similar to those seen in the crystal structure of the extracellular human growth hormone receptor [De Vos, A. M., Ultsch, M., & Kossiakoff, A.
G, Williams, N, Ruegg, A, Birch, C, Weber, K, Hofstädter, J A, Robinson, M, Aguet, G, Garotta, D, Schlatter, W, Huber   +9 more
openaire   +2 more sources

Cells expressing intracytoplasmic immunoglobulins in secreting and hyposecreting cases of alpha chain disease.

Archives de l'Institut Pasteur d'Algerie. Institut Pasteur d'Algerie, 1991
Alpha chain disease proteins (ACDP) originated probably from secreting plasma-cells predominantly present in diffuse and massive enteromesenteric lymphoid infiltration. Very decreased levels of abnormal alpha chain molecules were detected in sera of patients with immunoblastic lymphoma occurring in the late course of the disease.
H, Rabhi, M, Ghaffor, M, Benhalima-Bouali, M C, Abbadi   +3 more
openaire   +1 more source

Mutagenesis of immunoglobulin-like domains from the extracellular human interferon-γ receptor α chain and their recognition by neutralizing antibodies monitored by surface plasmon resonance technology

Journal of Immunological Methods, 1995
The extracellular portion of the human interferon-gamma receptor (IFN-gamma R) is predicted to adopt two Ig-like domains each with Ig superfamily type C2 topology. Surface plasmon resonance technology has been used here to compare the equilibrium and kinetic constants for binding reactions between these and several mutant domains, and neutralising anti-
N, Ruegg, G, Williams, A, Birch, J A, Robinson, D, Schlatter, W, Huber   +5 more
openaire   +2 more sources

Lack of association between atopic eczema and the genetic variants of interleukin‐4 and the interleukin‐4 receptor α chain gene: heterogeneity of genetic backgrounds on immunoglobulin E production in atopic eczema patients

Clinical & Experimental Allergy, 2001
Background The genetic background of atopic eczema might be heterogeneous and there is a possibility that immunoglobulin (Ig)E responsiveness in patients with atopic eczema is controlled separately from the development of atopic eczema. Although both interleukin (IL)‐4 and the IL‐4 receptor α chain have an important role for IgE production and are ...
K, Tanaka, H, Sugiura, M, Uehara, Y, Hashimoto, C, Donnelly, D S, Montgomery   +5 more
openaire   +2 more sources

α-Chains of Immunoglobulin A from Rabbits of Different Allotype: Composition and N-Terminal Sequence

Nature, 1969
STUDIES of the three chief classes of immunoglobulins in the rabbit, IgG, IgA and IgM, have shown that they all possess the basic four chain structure proposed by Porter1 of two light and two heavy chains, and that while the light chains are common to all three classes the heavy chains, γ, α and μ respectively, are class specific, and differ ...
openaire   +2 more sources

Alpha chain disease: immunoglobulin abnormalities, pathogenesis and current concepts.

The British journal of cancer. Supplement, 1976
The laboratory findings upon which the diagnosis of alpha chain disease relies and the main results of immunochemical, structural and biosynthetic studies of the pathological immunoglobulin are reviewed briefly. The pathogenesis of the disease is discussed in view of its possibly non-malignant nature at the early stage and of its peculiar geographic ...
openaire   +1 more source

Functionally distinct NF-kappa B binding sites in the immunoglobulin kappa and IL-2 receptor alpha chain genes.

Science (New York, N.Y.), 1989
The interleukin-2 receptor alpha (IL-2R alpha) chain gene contains a sequence similar to the immunoglobulin (Ig) kappa (kappa) enhancer NF-kappa B binding site. This site, which is bound by the nuclear protein, NF-kappa B, is critical for Ig kappa gene expression.
S L, Cross, N F, Halden, M J, Lenardo, W J, Leonard   +3 more
openaire   +1 more source

Human genes for the immunoglobulin gamma-chain (Gm) allotypes and for the T cell receptor alpha-chain are distantly linked or unlinked.

Experimental and clinical immunogenetics, 1991
Since the genes for two of the T cell receptor (TCR) chains (alpha and delta) and for the immunoglobulin (Ig) heavy chains (alpha, gamma, delta, epsilon and mu) are all on the long arm of human chromosome 14, it is of interest to determine if they are genetically linked and, if so, how strongly.
M J, Sheehy, C A, Emler, T W, Mak, J P, Pandey   +3 more
openaire   +1 more source

Cloning and characterization of sheep ( Ovis aries ) immunoglobulin α chain

Immunogenetics, 1998
White, Greg, Roche, P., Brandon, M., Newton, S., Meeusen, E.   +4 more
openaire   +3 more sources