Results 61 to 70 of about 398,949 (291)

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

Targeted therapy of bronchial asthma in children and adolescents: А narrative review

Фармация и фармакология (Пятигорск)
The aim. To evaluate the results of clinical studies on the efficacy and safety of bronchial asthma (BA) therapy with genetically engineered biologicals (GEBP) in children and adolescents.Materials and methods.
M. S. Matevosova, L. I. Agapitov, I. A. Averina, I. V. Sokolova, S. V. Zotova, R. A. Chernigovskiy   +5 more
doaj   +1 more source

Limited humoral immunoglobulin E memory influences serum immunoglobulin E levels in blood [PDF]

Clinical & Experimental Allergy, 2009
SummaryThe switch of B cells expressing membrane‐bound Igs, which serve as antigen receptors, to antibody‐secreting plasmablasts and finally to non‐dividing, long‐lived plasma cells (PCs) lacking an antigen receptor, marks the terminal differentiation of a B cell.
Achatz-Straussberger, G., Zaborsky, N., Königsberger, S., Feichtner, S., Lenz, S., Peckl-Schmid, D., Lamers, M., Achatz, G.   +7 more
openaire   +3 more sources

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Correlating Salivary Levels of Immunoglobin E and Human Eosinophil Cationic Protein in the Aseer Cohort with Recurrent Apthous Stomatitis

International Journal of General Medicine, 2023
Khalil Assiri,1 Jagadish Hosmani,1 Sandeepa Nuchilakath Chalikkandy,1 Abdullah M Alkahtani,2 Raghad Mohammed Alhanif,3 Sarah Ahmed Alsarh,3 Shankargouda Patil,4 Rodolfo Reda,5 Luca Testarelli5 1Department of Diagnostic Dental Sciences, College of ...
Assiri K, Hosmani J, Chalikkandy SN, Alkahtani AM, Alhanif RM, Alsarh SA, Patil S, Reda R, Testarelli L   +8 more
doaj  

Substantiation of the effectiveness of various materials for the treatment of pulpitis of deciduous teeth

Эндодонтия Today, 2020
Aim. The purpose is to justify the effective and safe use of various materials for the treatment of pulpitis of temporary teeth by amputation methods. Materials and methods.
O. L. Shevchenko, A. A. Antonova
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Serum Immunoglobulin E in Pemphigus

Journal of Investigative Dermatology, 1978
Immunoglobulin E levels in the sera of patients with pemphigus (12 with Brazilian pemphigus foliaceus (BPF) and 11 with pemphigus vulgaris (PV)) were determined by means of a solid phase radioimmunoassay. A significant increase in IgE level was observed in BPF patients compared to the level of IgE in PV patients and healthy adults.
Bruns, Gailon R, Ablin, Richard J, Guinan, Patrick D   +2 more
openaire   +2 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

A Multi-Center Study of the Prevalence and Characteristics of Eosinophilic Phenotype and High IgE Levels Among Chinese Patients with Severe Asthma [Corrigendum]

Journal of Asthma and Allergy, 2023
Ko FWS, Wang JKL, Hui DSC, et al. J Asthma Allergy. 2023;16:173-182. The authors have advised there is an error in Table 1. Table 1 on Page 177, in the third-to-last row, data addressing Median (IQR) for Eosinophil count, cells/mm3 should read from 3.2 ...
Ko FWS, Wang JKL, Hui DSC, Chan JWM, Cheung PS, Yeung YC, Sin KM, Ip MSM   +7 more
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