Results 61 to 70 of about 32,470,234 (258)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Are Specific Immunoglobulin (IgE and IgG) and Tryptase Levels Correlated with the Severity of Allergic Reactions in Patients with Bee Venom Hypersensitivity?

Journal of Pharmacopuncture
Objectives: This review aims to evaluate the clinical utility of specific immunoglobulins (IgE and IgG) and serum tryptase levels as biomarkers for predicting allergic reaction severity in patients with bee venom hypersensitivity.
Hee-Jun Na, Jae-Wan Jung, Yun-Suk Lee, Jun-Sang Yu   +3 more
doaj   +1 more source

Management of drug allergy-clinical update

Indian Journal of Allergy Asthma and Immunology, 2022
The new classification of drug hypersensitivity reactions (DHRs) is based on phenotypes, endotypes, and biomarkers. Immediate and delayed reactions are the clinical phenotypic presentation while endotypes are based on cellular, biological mediators, and ...
P C Kathuria, Manisha Rai
doaj   +1 more source

Intravenous immunoglobulin treatment in children with PANS/PANDAS conditions [PDF]

, 2021
Key messages: PANS (Pediatric Acute onset Neuropsychiatric Syndrome)/PANDAS (Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal infections) is described as an abrupt, dramatic onset of obsessive-compulsive disorder (OCD) or ...
Grøvan, Anette Olsson, Frønsdal, Katrine Bjørnebek   +1 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Immune checkpoint inhibitor-related urticaria characterized by a distinct autoimmune and autoallergic signatures

Dermatologica Sinica
Background: Immune checkpoint inhibitors (ICI) are increasingly used and are associated with a variety of cutaneous immune-related adverse events (irAEs). While urticarial eruptions are commonly observed in clinical practice, they are rarely described as
Chun-Bing Chen, Tsun-Hao Hsu, I-Wen Chen, Pei-Ni Chang, Chuang-Wei Wang, Wen-Hung Chung   +5 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Oral Manifestations of Job’s Syndrome in a Paediatric Dental Patient – A Case Report [PDF]

Journal of Clinical and Diagnostic Research, 2016
Job’s syndrome or Hyperimmunoglobulin E Syndrome (HIES) is a rare primary immunodeficiency with marked increase in serum immunoglobulin E (IgE) levels and eczematous dermatitis.
Jeswin James, Anupam Kumar Thekkeveetil, Kannan Vadakkepurayil   +2 more
doaj   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source