Proceedings of the National Academy of Sciences of the United States of America, 1972 A technique for the solid-phase conjugation of ferritin to monovalent antibodies (Fab-fragments of immunoglobulin G) is described in which Fab-fragments from sheep antiserum to rabbit Fab-fragments are first adsorbed to Sepharose containing insolubilized
J P Kraehenbühl, James D. Jamieson
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Monovalent Fab' immunoglobulin fragments from endemic pemphigus foliaceus autoantibodies reproduce the human disease in neonatal Balb/c mice. [PDF]
Journal of Clinical Investigation, 1990 Fogo selvagem (FS) is an autoimmune disease caused by IgG autoantibodies to desmoglein I (DG-I), a desmosomal glycoprotein. We have previously shown that the autoantibodies in these patients are pathogenic and restricted mainly to the IgG4 subclass.
Barbara Rock +2 more
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Function of Individual 30S Subunit Proteins of Escherichia coli . Effect of Specific Immunoglobulin Fragments (Fab) on Activities of Ribosomal Decoding Sites [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 1974 Specific anti-30S protein immunoglobulin G fragments (Fab) were used to determine the contribution of each of the 30S ribosomal proteins to: (1) polyphenylalanine synthesis, (2) initiation factor-dependent binding of fMet-tRNA, (3) T-factor-dependent ...
J.C. Lelong +5 more
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Retained antigen-binding activity of Fab alpha fragments of human monoclonal immunoglobulin A1 (IgA1) cleaved by IgA1 protease [PDF]
Infection and Immunity, 1986 Bendt Mansa, Mogens Kilian
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Facilitation of complement-dependent killing of the Lyme disease spirochete, Borrelia burgdorferi, by specific immunoglobulin G Fab antibody fragments [PDF]
Infection and Immunity, 1993 Sims K. Kochi, R C Johnson, A P Dalmasso
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PLoS ONE, 2023 The importance and fast growth of therapeutic monoclonal antibodies, both innovator and biosimilar products, have triggered the need for the development of characterization methods at high resolution such as nuclear magnetic resonance (NMR) spectroscopy.
Donald Gagné +12 more
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Effect of IgG fragments in IVIG(pH4)on phagocytosis of sensitized erythrocytes by macrophage
Zhongguo shuxue zazhi, 2022 Objective To research the effect of the Fc, Fab and F(ab′)2 fragments of immunoglobulin G, the main components of Human Immunoglobulin(pH4) for Intravenous Injection(IVIG), on the phagocytic function of macrophages derived from THP-1 cells. Methods First
Liyuan ZHU +6 more
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The Fab region of IgG impairs the internalization pathway of FcRn upon Fc engagement
Nature Communications, 2022 Disrupting the association between the Immunoglobulin G constant fragment (Fc) and the neonatal Fc receptor (FcRn) by engineered antibodies is a promising strategy to reduce autoantibody levels in autoimmune diseases.
Maximilian Brinkhaus +13 more
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Scientific Reports, 2023 With increased accessibility and tissue penetration, smaller antibody formats such as antibody fragments (Fab) and single chain variable fragments (scFv) show potential as effective and low-cost choices to full-length antibodies.
Aatir A. Tungekar, Lloyd W. Ruddock
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