Results 21 to 30 of about 24,709 (211)

A plug-and-play approach to antibody-based therapeutics via a chemoselective dual click strategy. [PDF]

, 2015
Although recent methods for the engineering of antibody-drug conjugates (ADCs) have gone some way to addressing the challenging issues of ADC construction, significant hurdles still remain.
Caddick, S, Chester, KA, Chudasama, V, Maruani, A, Miranda, E, Smith, ME   +5 more
core   +1 more source

Structural Basis for Enhanced HIV-1 Neutralization by a Dimeric Immunoglobulin G Form of the Glycan-Recognizing Antibody 2G12

Cell Reports, 2013
The human immunoglobulin G (IgG) 2G12 recognizes high-mannose carbohydrates on the HIV type 1 (HIV-1) envelope glycoprotein gp120. Its two antigen-binding fragments (Fabs) are intramolecularly domain exchanged, resulting in a rigid (Fab)2 unit including ...
Yunji Wu, Anthony P. West, Jr., Helen J. Kim, Matthew E. Thornton, Andrew B. Ward, Pamela J. Bjorkman   +5 more
doaj   +1 more source

Inhibition by small-molecule ligands of formation of amyloid fibrils of an immunoglobulin light chain variable domain. [PDF]

, 2015
Overproduction of immunoglobulin light chains leads to systemic amyloidosis, a lethal disease characterized by the formation of amyloid fibrils in patients' tissues. Excess light chains are in equilibrium between dimers and less stable monomers which can
Brumshtein, Boris, Cascio, Duilio, Eisenberg, David S, Esswein, Shannon R, Ly, Alan T, Phillips, Martin L, Salwinski, Lukasz, Sawaya, Michael R   +7 more
core   +1 more source

Three-Dimensional Structure of the Fab′ Fragment of a Human Immunoglobulin at 2.8-Å Resolution [PDF]

Proceedings of the National Academy of Sciences, 1973
The structure of the Fab′ fragment of a human myeloma immunoglobulin was determined by x-ray crystallographic analysis at 2.8-Å resolution. The Fourier map of the electron density was correlated with the aminoacid sequence to obtain a three-dimensional model. Four globular subunits, which correspond to the homology regions of the light and heavy chains,
Roberto J. Poljak, B. L. Chen, H. P. Avey, Frederick Saul, L. M. Amzel, R. P. Phizackerley   +5 more
openaire   +3 more sources

Investigating protein–excipient interactions of a multivalent VHH therapeutic protein using NMR spectroscopy

mAbs, 2022
Multispecific therapeutic proteins come in a variety of formats, including bi- and tri-specific antibodies, dual-variable domain antibodies, and CrossMabs.
Jainik Panchal, Bradley T. Falk, Valentyn Antochshuk, Mark A. McCoy   +3 more
doaj   +1 more source

Cell-Free Synthesis Meets Antibody Production: A Review

Antibodies, 2015
Engineered antibodies are key players in therapy, diagnostics and research. In addition to full size immunoglobulin gamma (IgG) molecules, smaller formats of recombinant antibodies, such as single-chain variable fragments (scFv) and antigen binding ...
Marlitt Stech, Stefan Kubick
doaj   +1 more source

Chimerization of antibodies by isolation of rearranged genomic variable regions by the polymerase chain reaction [PDF]

, 1991
We describe a new method for amplification, by polymerase chain reaction (PCR), of rearranged segments encoding the variable part of light and heavy chains of an antibody (Ab) from the chromosomal DNA of hybridoma cells for the chimerization ofAbs.
Kaluzab, Brigitte, Schwirzke, Marina, Weidle, Ulrich H., Weiss, Elisabeth H., Weissenhorn, Winfried   +4 more
core   +1 more source

The structures of secretory and dimeric immunoglobulin A [PDF]

, 2020
Secretory (S) Immunoglobulin (Ig) A is the predominant mucosal antibody, which binds pathogens and commensal microbes. SIgA is a polymeric antibody, typically containing two copies of IgA that assemble with one joining-chain (JC) to form dimeric (d) IgA ...
Haloi, Nandan, Huey-Tubman, Kathryn E., Kumar Bharathkar, Sonya, Malyutin, Andrey G., Parker, Benjamin W., Stadtmueller, Beth M., Tajkhorshid, Emad   +6 more
core  

Few and Far Between: How HIV May Be Evading Antibody Avidity [PDF]

, 2010
No ...
Bjorkman, Pamela J., Klein, Joshua S.
core   +3 more sources

Modeling and Molecular Dynamic Simulation of F(ab′) Fragment of Nimotuzumab for Lung Cancer Diagnostics

Bioinformatics and Biology Insights, 2021
Lung cancer is one of the leading causes of cancer-related deaths in the world among both men and women. Several studies in the literature report that overexpression and mutation of the epidermal growth factor receptor (EGFR) are implicated in the ...
Yurika Sastyarina, Ade Rizqi Ridwan Firdaus, Zuhrotun Nafisah, Ari Hardianto, Muhammad Yusuf, Martalena Ramli, Abdul Mutalib, Ukun MS Soedjanaatmadja   +7 more
doaj   +1 more source