Results 31 to 40 of about 50,813 (225)

First clinical experience with fractionated intracavitary radioimmunotherapy using [177Lu]Lu-6A10-Fab fragments in patients with glioblastoma: a pilot study

EJNMMI Research, 2023
Background Following resection and standard adjuvant radio- and chemotherapy, approved maintenance therapies for glioblastoma are lacking. Intracavitary radioimmunotherapy (iRIT) with 177Lu-labeled 6A10-Fab fragments targeting tumor-associated carbonic ...
Wolfgang Roll, Michael Müther, Guido Böning, Astrid Delker, Nils Warneke, Franz-Josef Gildehaus, Michael Schäfers, Walter Stummer, Reinhard Zeidler, Hans-Jürgen Reulen, Lars Stegger   +10 more
doaj   +1 more source

Unraveling the regulation of pyocyanin synthesis by RsmA through MvaU and RpoS in Pseudomonas aeruginosa ID4365

Journal of Basic Microbiology, Volume 63, Issue 1, Page 51-63, January 2023., 2023
Abstract Pyocyanin is a phenazine with redox activity produced by Pseudomonas aeruginosa that is harmful to other bacteria and eukaryotic organisms by generating reactive oxygen species. Gene regulation of pyocyanin synthesis has been addressed in the PAO1 and PA14 strains and involves the three‐quorum sensing systems Las, Rhl, and Pqs; the regulators ...
Luis F. Montelongo‐Martínez, Cristina Hernández‐Méndez, Luis F. Muriel‐Millan, René Hernández‐Estrada, Misael J. Fabian‐Del Olmo, Abigail González‐Valdez, Gloria Soberón‐Chávez, Miguel Cocotl‐Yañez   +7 more
wiley   +1 more source

Platelets and lymphocytes drive progressive penumbral tissue loss during middle cerebral artery occlusion in mice

Journal of Neuroinflammation, 2021
Background In acute ischemic stroke, cessation of blood flow causes immediate tissue necrosis within the center of the ischemic brain region accompanied by functional failure in the surrounding brain tissue designated the penumbra.
Michael K. Schuhmann, Michael Bieber, Maximilian Franke, Alexander M. Kollikowski, David Stegner, Katrin G. Heinze, Bernhard Nieswandt, Mirko Pham, Guido Stoll   +8 more
doaj   +1 more source

Refinement of an ovine-based immunoglobulin therapy against SARS-CoV-2, with comparison of whole IgG versus F(ab′)2 fragments

Scientific Reports, 2023
The development of new therapies against SARS-CoV-2 is required to extend the toolkit of intervention strategies to combat the global pandemic. In this study, hyperimmune plasma from sheep immunised with whole spike SARS-CoV-2 recombinant protein has ...
Stephen Findlay-Wilson, Linda Easterbrook, Sandra Smith, Neville Pope, Matthew Aldridge, Gareth Humphries, Holger Schuhmann, Didier Ngabo, Emma Rayner, Ashley Otter, Thomas Coleman, Bethany Hicks, Rachel Halkerston, Kostis Apostolakis, Stephen Taylor, Susan Fotheringham, Amanda Horton, Irene CanoCejas, Matthew Wand, Julia A. Tree, Mark Sutton, Victoria Graham, Roger Hewson, Stuart Dowall   +23 more
doaj   +1 more source

Purification of the Major Outer Membrane Protein of Azospirillum brasilense, Its Affinity to Plant Roots, and Its Involvement in Cell Aggregation

Molecular Plant-Microbe Interactions, 2001
The major outer membrane protein (MOMP) of the nitrogen-fixing rhizobacterium Azospirillum brasilense strain Cd was purified and isolated by gel filtration, and antiserum against this protein was obtained.
Saul Burdman, Gabriella Dulguerova, Yaacov Okon, Edouard Jurkevitch   +3 more
doaj   +1 more source

Humanized CD30-Targeted Chimeric Antigen Receptor T Cells Exhibit Potent Preclinical Activity Against Hodgkin’s Lymphoma Cells

Frontiers in Cell and Developmental Biology, 2022
CD30-directed chimeric antigen receptors (CARs) with single chain antibody fragment (scFv)-binding domains from murine HRS3 show strong cytotoxicity to Hodgkin’s Lymphoma cells and have been used in clinical trials.
Jing Guo, Shuai He, Yongjie Zhu, Wei Yu, Dong Yang, Xudong Zhao   +5 more
doaj   +1 more source

Fab-Four cosmography to tackle the Hubble tension [PDF]

Universe 2023, 9(7), 311, 2023
In the context of the Fab-Four theory of gravity in a Friedmann-Lema\^itre-Robertson-Walker background, in this work we use the cosmography approach to study a particular self-tuning filter solution focused on a zero-curvature fixed point to study the $H_0$ tension.
arxiv   +1 more source

Structural Basis for Enhanced HIV-1 Neutralization by a Dimeric Immunoglobulin G Form of the Glycan-Recognizing Antibody 2G12

Cell Reports, 2013
The human immunoglobulin G (IgG) 2G12 recognizes high-mannose carbohydrates on the HIV type 1 (HIV-1) envelope glycoprotein gp120. Its two antigen-binding fragments (Fabs) are intramolecularly domain exchanged, resulting in a rigid (Fab)2 unit including ...
Yunji Wu, Anthony P. West, Jr., Helen J. Kim, Matthew E. Thornton, Andrew B. Ward, Pamela J. Bjorkman   +5 more
doaj   +1 more source

Investigating protein–excipient interactions of a multivalent VHH therapeutic protein using NMR spectroscopy

mAbs, 2022
Multispecific therapeutic proteins come in a variety of formats, including bi- and tri-specific antibodies, dual-variable domain antibodies, and CrossMabs.
Jainik Panchal, Bradley T. Falk, Valentyn Antochshuk, Mark A. McCoy   +3 more
doaj   +1 more source

Mean Field Approach for a Statistical Mechanical Model of Proteins [PDF]

J. Chem. Phys., vol.119, pag.1248 (2003), 2003
We study the thermodynamical properties of a topology-based model proposed by Galzitskaya and Finkelstein for the description of protein folding. We devise and test three different mean-field approaches for the model, that simplify the treatment without spoiling the description.
arxiv   +1 more source