Results 41 to 50 of about 24,709 (211)

Lupus serum IgG induces microglia activation through Fc fragment dependent way and modulated by B-cell activating factor

Journal of Translational Medicine, 2019
Background Neuropsychiatric manifestations are frequent in patients with systemic lupus erythematosus (SLE), yet the etiology and pathogenesis of brain damage in SLE remains unclear.
Chunshu Yang, Xiaoyu Hou, Qianhui Feng, Yingzhuo Li, Xuejiao Wang, Ling Qin, Pingting Yang   +6 more
doaj   +1 more source

Structure of FcRY, an avian immunoglobulin receptor related to mammalian mannose receptors, and its complex with IgY [PDF]

, 2011
Fc receptors transport maternal antibodies across epithelial cell barriers to passively immunize newborns. FcRY, the functional counterpart of mammalian FcRn (a major histocompatibility complex homolog), transfers IgY across the avian yolk sac, and ...
BENNETT, Bottcher, Burmeister, Dube, East, Kowalczyk, Leach, Linden, Llorca, Martin, Mayer, Mertens, P. J. Bjorkman, Rivera-Calzada, Roopenian, Simister, Simister, Taylor, Tressler, Vaughn, Western, Woof, Y. He   +22 more
core   +3 more sources

Variable domain N-linked glycosylation and negative surface charge are key features of monoclonal ACPA: implications for B-cell selection

, 2018
Autoreactive B cells have a central role in the pathogenesis of rheumatoid arthritis (RA), and recent findings have proposed that anti-citrullinated protein autoantibodies (ACPA) may be directly pathogenic.
Amara, Khaled, Baeten, Dominique, Gabay, Cem, Gronwall, Caroline, Israelsson, Lena, Klareskog, Lars, Lanzavecchia, Antonio, Lloyd, Katy A., Lundberg, Karin, Lundstrom, Susanna L., Malmstrom, Vivianne, Mueller, Daniel L., Piccoli, Luca, Reed, Evan, Steen, Johanna, Titcombe, Philip J., Zhou, Diana, Zubarev, Roman A.   +17 more
core   +2 more sources

ADAR1 as a Placental Innate Immune Rheostat Sustaining the Homeostatic Balance of Intrinsic Interferon Response at the Maternal‐Fetal Interface

Advanced Science, EarlyView.
This study reveals that ADAR1, an RNA‐editing enzyme, fine‐tunes immune responses in the placenta by preventing the accumulation of immunogenic double‐stranded RNAs (dsRNAs) from interferon‐stimulated genes. The loss of ADAR1 in the placenta leads to excessive interferon signaling restricted to the junctional zone, disrupting placental development and ...
Xiaogang Chen, Xiangchao Xu, Jiahao Chen, Huiru Zhang, Wanshan Zheng, Wenzhe Yu, Xiaoqian Hu, Bin Cao   +7 more
wiley   +1 more source

Antigenic polypeptide fragments of a receptor related to the Fab fragment of human immunoglobulin from thymus-derived lymphocytes. [PDF]

Proceedings of the National Academy of Sciences, 1982
Certain thymus-derived lymphocytes of man and other primates express surface components related to the variable region of immunoglobulin heavy chains but lack constant region determinants defining any known immunoglobulin class. To obtain structural information on this molecule that can be used for comparison with known immunoglobulins and other ...
John Maxwell, A C Wang, J C Hunt, J J Marchalonis   +3 more
openaire   +3 more sources

Long Non‐Coding RNA IGFRIL Couples with PTBP1 to Destabilize IGFBP3 mRNA to Promote the IGF1R‐AKT‐mTOR Axis and Hepatocellular Carcinoma

Advanced Science, EarlyView.
The limited understanding of IGFR pathway activation hinders its clinical application in HCC. Here, IGFRIL is identified as a novel non‐coding activator of the IGF1R, which recruits PTBP1 to destabilize IGFBP3 mRNA and activates IGF1R, and proposes IGFRIL as a novel actionable target for HCC patients.
Jing Zhang, Chengming Gao, Haibei Li, Yuying Chen, Liting Yang, Qian Jin, Lan Feng, Xia Wang, Xinyi Liu, Hongxia Chen, Rong Ye, Yuanchao Xue, Huiyun Wang, Musheng Zeng, Ming Yang, Huaiqiang Ju, Chengzhi Gao, Guangming Zhou, Qi Zhang, Qian Zhang, Geng Qin, Yuanfeng Li, Yahui Wang, Aiqing Yang, Anfeng Si, Qingfeng Song, Fuchu He, Pengbo Cao, Gangqiao Zhou   +28 more
wiley   +1 more source

Sensing of the melanoma biomarker TROY using silicon nanowire field-effect transistors [PDF]

, 2016
Antibody-functionalized silicon nanowire field-effect transistors have been shown to exhibit excellent analyte detection sensitivity enabling sensing of analyte concentrations at levels not readily accessible by other methods.
Erramilli, Shyamsunder, Hong, Mi, Kim, Daniel, Maedler, Carsten, Mohanty, Pritiraj, Spanjaard, Remco A.   +5 more
core   +1 more source

Structure of an immunoglobulin Fab fragment specific for poly(dG).poly(dC).

Journal of Biological Chemistry, 1994
Jel 72 is a murine monoclonal antibody that is highly specific for the right-handed DNA duplex formed by poly(dG).poly(dC). The three-dimensional structure of the antigen-binding fragment (Fab) of Jel 72 has been determined by x-ray crystallographic methods and refined to 2.7-A resolution.
Wayne F. Anderson, Jeremy S. Lee, Alastair K S Muir, Clifford D. Mol   +3 more
openaire   +3 more sources

Lecithin‐Modified Nanoscale Oxygen Carriers (LENOX): New Designed Perfluorocarbon‐Based Artificial Oxygen Carriers Ready‐to‐Use in Clinically Relevant Media

Advanced NanoBiomed Research, EarlyView.
Perfluorocarbon‐based artificial oxygen carriers have long been of scientific interest for because they can be used as oxygen donors in medical applications. Lecithin‐modified nanoscale oxygen carriers (LENOX) are a newly designed nanoscaled emulsion based on perfluorodecalin, which is characterized by its compatibility with numerous clinically ...
Fabian Nocke, Martin A. Schroer, Marina Penzel, Miriam Cantore, Andrea U. Steinbicker, Katja B. Ferenz   +5 more
wiley   +1 more source

Protein L: a novel reagent for the detection of Chimeric Antigen Receptor (CAR) expression by flow cytometry

Journal of Translational Medicine, 2012
Background There has been significant progress in the last two decades on the design of chimeric antigen receptors (CAR) for adoptive immunotherapy targeting tumor-associated antigens.
Zheng Zhili, Chinnasamy Nachimuthu, Morgan Richard A   +2 more
doaj   +1 more source