Results 81 to 90 of about 24,709 (211)

Dose Selection for DuoBody®‐CD40x4‐1BB (GEN1042/BNT312) Using a mPBPK/RO Model Leveraging Preclinical and Clinical Data

Clinical Pharmacology &Therapeutics, Volume 118, Issue 2, Page 418-427, August 2025.
Optimizing target engagement for bispecific antibodies (bsAbs) is challenging, as bsAbs bind to two different targets in vivo to form a trimolecular complex (trimer), and likely display a bell‐shaped concentration–response curve. bsAbs trimer formation is expected to be related to efficacy and safety, and determining the dose level at which it is ...
Gaurav Bajaj, Dmitry Shchelokov, Oleg Demin Jr, Homer C. Adams 3rd, Yan Feng, Leonid Gibiansky, Saskia van der Lee, Anandhi Johri, Merzu Belete, Alexander Muik, Porntula Panorchan, Özlem Türeci, Uğur Sahin, Tahamtan Ahmadi, Manish Gupta, Oleg Demin, Craig Thalhauser   +16 more
wiley   +1 more source

Forced Degradation Testing as Complementary Tool for Biosimilarity Assessment [PDF]

, 2019
Oxidation of monoclonal antibodies (mAbs) can impact their efficacy and may therefore represent critical quality attributes (CQA) that require evaluation.
Dyck, Yan Felix Karl, Jabs, Wolfgang, Joseph, Jan Felix, Parr, Maria Kristina, Rehm, Daniel, Sandig, Volker, Winkler, Karsten   +6 more
core   +1 more source

Rhinovirus, an Age‐Old Problem Yet to be Solved: A Comprehensive Review Discussing Modern Therapeutics

Health Science Reports, Volume 8, Issue 8, August 2025.
ABSTRACT Background and Aims The human Rhinovirus, a positive‐sense, single‐stranded RNA virus within the Enterovirus genus of the Picornaviridae family, is the most prevalent viral pathogen in humans and the primary cause of the common cold (Verywell Health 2024).
Srinjoy Maitra, Jenifer Rajak, Agnik Ghoshal, Bedaprana Roy, Shoham Ghosh, Arup Kumar Mitra, Ajoy Kumer, Bikram Dhara   +7 more
wiley   +1 more source

Vibrational studies of the disulfide group in proteins. VII. Normal mode analysis of the Raman spectra of erabutoxin, γ‐II crystallin and immunoglobulin [PDF]

, 1992
Normal mode calculations have been made on the known structures of disulfide bridges in erabutoxin b, a form of γ‐II crystallin, and fragments (Fab, variable‐domain of Bence‐Jones proteins) of immunoglobulins.
Bernstein, Chen, Epp, Furey, Harada, Kitagawa, Krimm, McDermott, Pande, Pande, Qian, Qian, Qian, Saul, Smith, Sugeta, Sugeta, Summers, Wistow, Yu, Zav'yalov, Zhao, Zhao, Zhao   +23 more
core   +1 more source

The primary structure of the Fab fragment of protein KAU, a monoclonal immunoglobulin M cold agglutinin.

Journal of Biological Chemistry, 1991
The complete amino acid sequence of the Fab fragment of protein KAU, a human monoclonal cold agglutinin (IgMk) with anti-I activity, was determined. The light chain (L-chain) consists of 215 residues; the variable (V)L region belongs to the Hum/Kv325/kIIIb sub-subgroup that is preferentially selected in human IgM autoimmune response.
Jorge Ghiso, Blas Frangione, J Leoni, Fernando Goni   +3 more
openaire   +3 more sources

Experimental and Computational Insights into the Structural Dynamics of the Fc Fragment of IgG1 Subtype from Biosimilar VEGF‐Trap

Small Structures, Volume 6, Issue 8, August 2025.
The constant fragment (Fc) of the immunoglobulin G1 (IgG1) subtype is a widely used scaffold for designing advanced therapeutics. Herein, together with the integration of experimental and computational techniques, this study reveals the structural dynamics of the N‐glycan‐bound Fc fragment of IgG1 from VEGF‐Trap, providing a new insight into enhancing ...
Ebru Destan, Engin Turkut, Alper Aldeniz, Jungmin Kang, Takehiko Tosha, Makina Yabashi, Baris Yilmaz, Ahmet Can Timucin, Hiroaki Matsuura, Yoshiaki Kawano, Irfan Cinkaya, Hasan DeMirci   +11 more
wiley   +1 more source

Non-specific binding of antibodies in immunohistochemistry: Fakes and facts [PDF]

, 2011
Protocols for blocking non-specific antibody (Ab) binding in immunohistochemistry are based on rather contradictory and outdated reports. This prompted us to prove, whether non-specific Ab binding may really lead to unwanted background staining in ...
Igor Buchwalow, Markus Tiemann, Vera Samoilova, Werner Boecker   +3 more
core   +1 more source

Controlled method of reducing electrophoretic mobility of macromolecules, particles, or cells [PDF]

, 1992
A method of reducing electrophoretic mobility of macromolecules, particles, cells, and other substances is provided which comprises interacting in a conventional electrophoretic separating procedure, the substances with a polymer-linked affinity compound
Vanalstine, James M.
core   +1 more source

Antibody-Specific Model of Amino Acid Substitution for Immunological Inferences from Alignments of Antibody Sequences [PDF]

, 2017
Antibodies are glycoproteins produced by the immune system as a dynamically adaptive line of defense against invading pathogens. Very elegant and specific mutational mechanisms allow B lymphocytes to produce a large and diversified repertoire of ...
Anisimova, Maria, Kazandjian, Linda, Mirsky, Alexander   +2 more
core   +1 more source

Structural features of human immunoglobulin G that determine isotype-specific differences in complement activation. [PDF]

, 1993
Although very similar in sequence, the four subclasses of human immunoglobulin G (IgG) differ markedly in their ability to activate complement. Glu318-Lys320-Lys322 has been identified as a key binding motif for the first component of complement, C1q ...
Morrison, SL, Smith, RI, Tao, MH
core