Results 81 to 90 of about 50,813 (225)
Computer Applications in Engineering Education, Volume 33, Issue 3, May 2025.ABSTRACT Virtual reality (VR) provides the opportunity to deepen learning and experience learning situations in higher education that were previously inaccessible. Knowledge from theoretical classroom lectures is connected to scenarios from industrial practice and is thus experienced, consolidated, and anchored. VR allows students to immerse themselves
Iris Perner‐Nochta +6 more
wiley +1 more source
Mass Spectrometry Reviews, Volume 44, Issue 3, Page 213-453, May/June 2025.Abstract The use of matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this review is the 12th update of the original article published in 1999 and brings coverage of the literature to the end of 2022.
David J. Harvey
wiley +1 more source
Structure of the Fab fragment of a humanized 5E5 antibody to a cancer‐specific Tn‐MUC1 epitope
Acta Crystallographica Section D, Volume 81, Issue 5, Page 223-233, May 2025.The structure of the humanized Fab from murine monoclonal antibody 5E5 specific for tumor antigen Tn‐MUC1 has been determined to 1.57 Å resolution. The humanization process has imposed changes in the framework regions of the Fv which may have affected the Vh–Vl interface.The structure of the humanized Fab from murine monoclonal antibody 5E5 specific ...
Wei Li +7 more
wiley +1 more source
Harnessing Avidity: Quantifying Entropic and Energetic Effects of Linker Length and Rigidity Required for Multivalent Binding of Antibodies to HIV-1 Spikes [PDF]
, 2018 Due to the low density of envelope (Env) spikes on the surface of HIV-1, neutralizing IgG antibodies rarely bind bivalently using both antigen-binding arms (Fabs) to crosslink between spikes (inter-spike crosslinking), instead resorting to weaker monovalent binding that is more sensitive to Env mutations.
arxiv +1 more source
The Structural Biology of T‐Cell Antigen Detection at Close Contacts
Immunological Reviews, Volume 331, Issue 1, May 2025.ABSTRACT T cells physically interrogate their targets using tiny membrane protrusions called microvilli, forming junctions ~400 nm in diameter and ~ 15 nm deep, referred to as “close contacts”. These contacts, which are stabilized by the binding of the small adhesion protein CD2 to its ligand, CD58 and locally exclude large proteins such as the ...
Yuan Lui +5 more
wiley +1 more source
A Brief Molecular History of Vγ9Vδ2 TCR‐Mediated Phosphoantigen Sensing
Immunological Reviews, Volume 331, Issue 1, May 2025.ABSTRACT Vγ9Vδ2 T‐cells are universally present in humans and represent one of the most prevalent TCR reactivities, evolutionarily conserved across diverse mammalian species. They are an innate‐like subset featuring a semi‐invariant TCR repertoire that drives their well‐recognized reactivity to small, non‐peptidic phosphoantigens (pAg). Crucially, they
Fiyaz Mohammed +2 more
wiley +1 more source
Diversity against adversity: How adaptive immunity evolves potent antibodies [PDF]
arXiv, 2008 How does immune system evolve functional proteins - potent antibodies - in such a short time? We address this question using a microscopic, protein-level, sequence-based model of humoral immune response with explicitly defined interactions between Immunoglobulins, host and pathogen proteins.
arxiv
Maternal IgE Influence on Fetal and Infant Health
Immunological Reviews, Volume 331, Issue 1, May 2025.ABSTRACT Immunoglobulin E (IgE) is the most recently discovered and evolved mammalian antibody type, best known for interacting with mast cells (MCs) as immune effectors. IgE‐mediated antigen sensing by MC provides protection from parasites, venomous animals, bacteria, and other insults to barrier tissues exposed to the environment.
Jozef Balla +2 more
wiley +1 more source
Factorized Asymptotic Bayesian Hidden Markov Models [PDF]
arXiv, 2012 This paper addresses the issue of model selection for hidden Markov models (HMMs). We generalize factorized asymptotic Bayesian inference (FAB), which has been recently developed for model selection on independent hidden variables (i.e., mixture models), for time-dependent hidden variables.
arxiv
Smaller $p$-values in genomics studies using distilled historical information [PDF]
arXiv, 2020 Medical research institutions have generated massive amounts of biological data by genetically profiling hundreds of cancer cell lines. In parallel, academic biology labs have conducted genetic screens on small numbers of cancer cell lines under custom experimental conditions.
arxiv